Results 111 to 120 of about 54,015 (281)

Three-dimensional culture of human meniscal cells: Extracellular matrix and proteoglycan production

BMC Biotechnology, 2008
Background The meniscus is a complex tissue whose cell biology has only recently begun to be explored. Published models rely upon initial culture in the presence of added growth factors. The aim of this study was to test a three-dimensional (3D) collagen
Norton H James, Ingram Jane A, Chow Yin, Mauerhan David, Gruber Helen E, Hanley Edward N, Sun Yubo   +6 more
doaj   +1 more source

Immunological characterization of a basement membrane-specific chondroitin sulfate proteoglycan

Journal of Cell Biology, 1989
Reichert's membrane, an extraembryonic membrane present in developing rodents, has been proposed as an in vivo model for the study of basement membranes. We have used this membrane as a source for isolation of basement membrane proteoglycans.
Kevin J. McCar, M. Accavitti
semanticscholar   +1 more source

Decorin as a multivalent therapeutic agent against cancer. [PDF]

, 2016
Decorin is a prototypical small leucine-rich proteoglycan that epitomizes the multifunctional nature of this critical gene family. Soluble decorin engages multiple receptor tyrosine kinases within the target-rich environment of the tumor stroma and tumor
Iozzo, Renato V., Neill, Thomas, Schaefer, Liliana   +2 more
core   +2 more sources

Chondroitin sulfate proteoglycan CSPG4 as a novel hypoxia-sensitive marker in pancreatic tumors. [PDF]

PLoS ONE, 2014
CSPG4 marks pericytes, undifferentiated precursors and tumor cells. We assessed whether the shed ectodomain of CSPG4 (sCSPG4) might circulate and reflect potential changes in CSPG4 tissue expression (pCSPG4) due to desmoplastic and malignant aberrations ...
Shereen Keleg, Alexandr Titov, Anette Heller, Thomas Giese, Christine Tjaden, Sufian S Ahmad, Matthias M Gaida, Andrea S Bauer, Jens Werner, Nathalia A Giese   +9 more
doaj   +1 more source

Direct quantification of brown algae-derived fucoidans in human plasma by a fluorescent probe assay [PDF]

arXiv, 2016
Fucoidan is a generic term for a class of fucose rich, structurally diverse sulfated polysaccharides that are found in brown algae and other marine organisms. Depending on the species from which the fucoidan is extracted, a wide variety of biological activities including antitumor, antiinflammatory, immune-modulating, antiviral, antibacterial and pro ...
arxiv  

B-Amyloid of Alzheimer\u27s Disease Induces Reactive Gliosis that Inhibits Axonal Outgrowth [PDF]

, 1993
Pathological lesions in the brains of patients with Alzheimer\u27s disease (AD) are characterized by dense deposits of the protein ,B-amyloid. The link between the deposition of B-amyloid in senile plaques and AD-associated pathology is, at present ...
Canning, David R., Dewitt, David A., Frederickson, R. C. A., McKeon, Robert J., Perry, George, Silver, Jerry, Wujek, Jerome R.   +6 more
core  

A novel approach for the characterisation of proteoglycans and biosynthetic enzymes in a snail model [PDF]

, 2011
Proteoglycans encompass a heterogeneous group of glycoconjugates where proteins are substituted with linear, highly negatively charged glycosaminoglycan chains.
Almeida, Igor Correia de, Cavalheiro, Renan Pelluzzi, Coulson-Thomas, Vivien Jane, Cunha, Gabriel L. A, Farias, Eduardo Henrique Cunha de, Gesteira, Tarsis Ferreira, Lima, Marcelo Andrade, Nader, Helena Bonciani, Nakayasu, Ernesto S, Ogata, Fernando Toshio, Toma, Leny   +10 more
core   +2 more sources

Platelet-derived growth factor-stimulated versican synthesis but not glycosaminoglycan elongation in vascular smooth muscle is mediated via Akt phosphorylation [PDF]

, 2014
Proteoglycans are associated with the initiation of atherosclerosis due to their binding of apolipoproteins on lipid particles leading to retention in the vessel wall.
Getachew, R, Little AM, P, Osman, N, Su, X, Thach, L, Wang, H, Zheng, W   +6 more
core   +1 more source

Endothelial Cell‐Specific Prolyl Hydroxylase‐2 Deficiency Augments Angiotensin II–Induced Arterial Stiffness and Cardiac Pericyte Recruitment in Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Endothelial prolyl hydroxylase‐2 (PHD2) is essential for pulmonary remodeling and hypertension. In the present study, we investigated the role of endothelial PHD2 in angiotensin II–mediated arterial stiffness, pericyte recruitment, and cardiac
Bo Liu, Heng Zeng, Han Su, Quinesha A. Williams, Jessie Besanson, Yingjie Chen, Jian‐Xiong Chen   +6 more
doaj   +1 more source

Ligand-induced Coupling versus Receptor Pre-association: Cellular automaton simulations of FGF-2 binding [PDF]

J. Theor. Biol. 227(2) 239-251 (2004), 2003
The binding of basic fibroblast growth factor (FGF-2) to its cell surface receptor (CSR) and subsequent signal transduction is known to be enhanced by Heparan Sulfate Proteoglycans (HSPGs). HSPGs bind FGF-2 with low affinity and likely impact CSR-mediated signaling via stabilization of FGF-2-CSR complexes via association with both the ligand and the ...
arxiv