Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration
JOR SPINE, Volume 9, Issue 1, March 2026.This study investigated the combined effects of dynamic compression and torsion with major pro‐catabolic cytokine interleukin‐1 beta (IL‐1β) and its inhibitor: interleukin‐1 receptor antagonist (IL‐1Ra), on bovine IVD in an ex vivo organ culture system and further evaluated the mechanical effects using a subject‐personalized finite element model based ...
Katherine B. Crump +8 more
wiley +1 more source
Scientific ReportsWhite adipocytes are a major component of white adipose tissue (WAT) and help to maintain systemic metabolic homeostasis by storing energy and secreting adipokines. In mice deficient in the protein WWP1 (WW domain-containing E3 ubiquitin protein ligase 1)
Yuka Nozaki +8 more
doaj +1 more source
JOR SPINE, Volume 9, Issue 1, March 2026.Goat nucleus pulposus cells cultured under clinically relevant oxygen, glucose, pH, and osmolarity revealed pH to have the most influential impact on viability and glycosaminoglycan synthesis. Interactions between factors showed that disc cell behavior is shaped by the microenvironment, highlighting its importance in regenerative therapy design for the
Niamh Wilson +5 more
wiley +1 more source
A Chondroitin Sulfate Proteoglycan PTPζ/RPTPβ Regulates the Morphogenesis of Purkinje Cell Dendrites in the Developing Cerebellum [PDF]
, 2003 Masahiko Tanaka +3 more
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Food Science &Nutrition, Volume 14, Issue 2, February 2026.Polysaccharides play a pivotal role in the development of safe and healthy foods. They ameliorate fatigue, preserve the microflora of the gastrointestinal tract, and provide health for the gut in living organisms. These biopolymers are applied for the fabrication of breakthrough drug delivery systems and potential platforms in regenerative medicine ...
M V N L Chaitanya +14 more
wiley +1 more source
Loss of chondroitin sulfate proteoglycan sulfation allows delayed sympathetic reinnervation after cardiac ischemia-reperfusion. [PDF]
Physiol Rep, 2023 Blake MR +5 more
europepmc +1 more source
CD44-related chondroitin sulfate proteoglycan, a cell surface receptor implicated with tumor cell invasion, mediates endothelial cell migration on fibrinogen and invasion into a fibrin matrix. [PDF]
, 1996 Craig A. Henke +4 more
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Neuropathology, Volume 46, Issue 1, February 2026.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Paloma Martínez‐Alesón +3 more
wiley +1 more source
Chondroitin Sulfate Proteoglycan 4 as a Marker for Aggressive Squamous Cell Carcinoma. [PDF]
Cancers (Basel), 2022 Chen K +9 more
europepmc +1 more source
Recovery of Forearm and Fine Digit Function After Chronic Spinal Cord Injury by Simultaneous Blockade of Inhibitory Matrix Chondroitin Sulfate Proteoglycan Production and the Receptor PTPσ. [PDF]
J Neurotrauma, 2023 Milton AJ +7 more
europepmc +1 more source