Results 131 to 140 of about 43,424 (239)

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source

Baishaoluoshi Decoction Mitigates Post‐Stroke Spasticity by Targeting Synaptic Plasticity Through the Nogo‐A/NgR Signaling Pathway

Brain and Behavior, Volume 16, Issue 1, January 2026.
Baishaoluoshi Decoction alleviates post‐stroke spasticity by downregulating inhibitory proteins (Nogo‐A/NgR) in the peri‐infarct brain region and reducing NgR/Olig2 co‐localization in oligodendrocytes, thereby enhancing synaptic plasticity. ABSTRACT Objective: This study systematically investigated the effects and molecular mechanisms of Baishaoluoshi ...
Xiongxing Sun, Shanshan Zeng, Shigao Lin, Lingying Wu, Xukun Tang, Jiajian Zhu, Yuhui Zhang, Lu Li, Ziming Chen, Xinyu Deng, Dahua Wu, Le Xie   +11 more
wiley   +1 more source

Correction: Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/planar cell polarity pathway. [PDF]

PLoS One, 2022
Lee YH, Kawakami K, HuangFu WC, Liu IH.
europepmc   +1 more source

Modulation of Receptor Protein Tyrosine Phosphatase Sigma Increases Chondroitin Sulfate Proteoglycan Degradation through Cathepsin B Secretion to Enhance Axon Outgrowth

Journal of Neuroscience, 2018
A. Tran, Sapna Sundar, Meigen Yu, B. Lang, J. Silver   +4 more
semanticscholar   +1 more source

Spatiotemporal distribution of chondroitin sulfate proteoglycans after optic nerve injury in rodents

, 2019
Craig S. Pearson, Andrea G. Solano, Sharada Tilve, Caitlin P. Mencio, Keith R. Martin, Herbert M. Geller   +5 more
openalex   +2 more sources

CDG due to Defective Membrane Transporters: Update

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Congenital disorders of glycosylation are genetic defects in the glycoprotein and glycolipid glycan assembly and attachment. Some 200 CDG have been reported since the first clinical description in 1980. Most CDG are enzymatic deficiencies, but 13 (6.5%) are defects in the ER, Golgi apparatus (GA), and plasma membrane transporters.
D. Quelhas, C. R. Ferreira, J. Jaeken
wiley   +1 more source

Nanomelic chondrocytes synthesize a glycoprotein related to chondroitin sulfate proteoglycan core protein.

, 1988
C. M. O'Donnell, K Kaczman-Daniel, Paul F. Goetinck, Barbara M. Vertel   +3 more
openalex   +1 more source

The Functional Epididymal Amyloid Cystatin‐Related Epididymal Spermatogenic (CRES) is a Component of the Mammalian Brain Extracellular Matrix

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
This study investigated if the epididymal amyloid CRES (cystatin‐related epididymal spermatogenic) is present in the male and female mammalian brain. CRES is expressed by hippocampal astrocytes, CA2 and CA3 neurons, and exhibits amyloid properties in the extracellular matrix.
Alejandra Gomez, Uyen T. Tran, Petar N. Grozdanov, Gail A. Cornwall   +3 more
wiley   +1 more source

Expression of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma cells is downregulated upon inhibition of BRAF. [PDF]

Oncol Rep, 2021
Uranowska K, Kalic T, Valtsanidis V, Kitzwögerer M, Breiteneder H, Hafner C.   +5 more
europepmc   +1 more source

Chondroitin/dermatan sulfate proteoglycan in human fetal membranes. Demonstration of an antigenically similar proteoglycan in fibroblasts.

, 1984
Michael J. Brennan, Å Oldberg, Michael D. Pierschbacher, Erkki Ruoslahti   +3 more
openalex   +1 more source