M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury [PDF]
Neural Regeneration Research, 2022 After spinal cord injury (SCI), astrocytes gradually migrate to and surround the lesion, depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar, which limits the spread of inflammation but hinders axon ...
Shui-Sheng Yu +8 more
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An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination [PDF]
Nature Communications, 2016 Chondroitin sulfate proteoglycans (CSPGs) secreted by astrocytes are known to inhibit OPC differentiation and remyelination. Here, the authors identify a novel CSPG synthesis inhibitor and find it can rescue OPC differentiation in vitroand accelerate ...
Michael B. Keough +12 more
doaj +3 more sources
Role of Chondroitin Sulfate Proteoglycan 5 in Steroid-Induced Cataract [PDF]
Cells, 2023 Steroid-induced cataracts (SIC) are defined as cataracts associated with the administration of corticosteroids. Long-term glucocorticoid treatment for inflammatory diseases reportedly increases the risk of SIC, and steroids can induce cataracts by ...
Woong-Sun Yoo +8 more
doaj +2 more sources
Binding of a Large Chondroitin Sulfate/Dermatan Sulfate Proteoglycan, Versican, to L-selectin, P-selectin, and CD44 [PDF]
Journal of Biological Chemistry, 2000 Here we show that a large chondroitin sulfate proteoglycan, versican, derived from a renal adenocarcinoma cell line ACHN, binds L-selectin, P-selectin, and CD44.
Hiroto Kawashima +5 more
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Increased Synthesis of Chondroitin Sulfate Proteoglycan Promotes Adult Hippocampal Neurogenesis in Response to Enriched Environment. [PDF]
J Neurosci, 2018 Chondroitin sulfate proteoglycan (CSPG) is a candidate regulator of embryonic neurogenesis. The aim of this study was to specify the functional significance of CSPG in adult hippocampal neurogenesis using male mice. Here, we showed that neural stem cells
Yamada J +4 more
europepmc +2 more sources
Chondroitin Sulfate Proteoglycan 4 and Its Potential As an Antibody Immunotherapy Target across Different Tumor Types. [PDF]
Front Immunol, 2017 Overexpression of the chondroitin sulfate proteoglycan 4 (CSPG4) has been associated with the pathology of multiple types of such as melanoma, breast cancer, squamous cell carcinoma, mesothelioma, neuroblastoma, adult and pediatric sarcomas, and some ...
Ilieva KM +11 more
europepmc +2 more sources
Induction of chondroitin sulfate proteoglycan synthesis and secretion in lymphocytes and monocytes. [PDF]
Journal of Cell Biology, 1983 The ability of mononuclear leukocytes to synthesize and secrete proteoglycans was evaluated. Using radiolabeling with H2 35SO4, it is shown that peripheral blood mononuclear cells (PBMC) and their major subpopulations (B cells, T cells, and monocytes ...
Daniel Levitt, Pei-Lee Ho
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SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer. [PDF]
PLoS ONE, 2012 SRPX2 (Sushi repeat-containing protein, X-linked 2) has recently emerged as a multifunctional protein that is involved in seizure disorders, angiogenesis and cellular adhesion. Here, we analyzed this protein biochemically. SRPX2 protein was secreted with
Kaoru Tanaka +14 more
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Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes. [PDF]
Oncotarget, 2017 Neurocan (NCAN), a secreted chondroitin sulfate proteoglycan, is one of the major inhibitory molecules for axon regeneration in nervous injury. However, its role in cancer is not clear.
Su Z +11 more
europepmc +2 more sources
Interaction of the NG2 chondroitin sulfate proteoglycan with type VI collagen. [PDF]
Journal of Cell Biology, 1990 The NG2 chondroitin sulfate proteoglycan is a membrane-associated molecule of approximately 500 kD with a core glycoprotein of 300 kD. Both the complete proteoglycan and a smaller quantity of the 300-kD core are immunoprecipitable with polyclonal and ...
William B. Stallcup +2 more
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