Chondroitin sulfate proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction [PDF]
eLife, 2022 Sympathetic denervation of the heart following ischemia/reperfusion induced myocardial infarction (MI) is sustained by chondroitin sulfate proteoglycans (CSPGs) in the cardiac scar. Denervation predicts risk of sudden cardiac death in humans.
Matthew R Blake +5 more
doaj +2 more sources
Invariant chain is the core protein of the Ia-associated chondroitin sulfate proteoglycan. [PDF]
Journal of Experimental Medicine, 1985 The murine Ia-associated chondroitin sulfate proteoglycan (CSPG) was studied both biochemically and immunochemically to determine the nature of its core protein.
Andrea J. Sant +3 more
openalex +2 more sources
Differential Expression of Proteoglycans in Tissue Remodeling and Lymphangiogenesis after Experimental Renal Transplantation in Rats [PDF]
PLoS ONE, 2010 BACKGROUND: Chronic transplant dysfunction explains the majority of late renal allograft loss and is accompanied by extensive tissue remodeling leading to transplant vasculopathy, glomerulosclerosis and interstitial fibrosis. Matrix proteoglycans mediate
Celie, Johanna W. A. M. +6 more
core +7 more sources
Chondroitin sulfate proteoglycan 4: An attractive target for antibody-based immunotherapy [PDF]
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesMultifunctional molecules involved in tumor progression and metastasis have been identified as valuable targets for immunotherapy. Among these, chondroitin sulfate proteoglycan 4 (CSPG4), a significant tumor cell membrane-bound proteoglycan, has emerged ...
Tomohiro KUROKAWA, Kohzoh IMAI
doaj +2 more sources
Proteoglycans and neuronal migration in the cerebral cortex during development and disease [PDF]
Frontiers in Neuroscience, 2015 Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many proteins including growth factors, chemokines, axon guidance molecules,
Nobuaki Maeda
core +4 more sources
Protamine neutralizes chondroitin sulfate proteoglycan-mediated inhibition of oligodendrocyte differentiation. [PDF]
PLoS ONE, 2017 Chondroitin sulfate proteoglycans (CSPGs), which are enriched in demyelinating plaques in neurodegenerative diseases, such as multiple sclerosis (MS), impair remyelination by inhibiting the migration and differentiation of oligodendrocyte precursor cells
Kazuya Kuboyama +4 more
doaj +2 more sources
Inhibition of neurite growth by the NG2 chondroitin sulfate proteoglycan [PDF]
The Journal of Neuroscience, 1994 The chondroitin sulfate proteoglycans (CSPGs) have been implicated as both positive and negative modulators of axonal growth; however, the functional properties of only a few specific CSPGs have been investigated. Here we demonstrate that NG2, an integral membrane CSPG expressed on the surfaces of glial progenitor cells, inhibits neurite growth from ...
Chang-Lin Dou, Joel M. Levine
openaire +3 more sources
Constitutive and TNFα-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy. [PDF]
Sci Transl Med, 2018 Pellegatta S +11 more
europepmc +2 more sources
Novel Insight Into Glycosaminoglycan Biosynthesis Based on Gene Expression Profiles
Frontiers in Cell and Developmental Biology, 2021 Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, heparan sulfate, and keratan sulfate, except for hyaluronan that is a free polysaccharide, are covalently attached to core proteins to form proteoglycans.
Yi-Fan Huang +2 more
doaj +1 more source
Molecules, 2021 Chondroitin sulfate is a proteoglycan component of the extracellular matrix (ECM) that supports neuronal and non-neuronal cell activity, provides a negative domain to the extracellular matrix, regulates the intracellular positive ion concentration, and ...
Shareen Singh +7 more
doaj +1 more source