Results 31 to 40 of about 43,424 (239)

Trps1 Regulates Development of Craniofacial Skeleton and Is Required for the Initiation of Palatal Shelves Fusion

Frontiers in Physiology, 2019
Trichorhinophalangeal syndrome (TRPS) is an autosomal dominant disorder resulting from heterozygous mutations of the TRPS1 gene. Common craniofacial abnormalities in TRPS patients include micrognathia, hypoplastic zygomatic arch, high-arched palate, and,
Kah Yan Cho, Brian P. Kelley, Brian P. Kelley, Daisy Monier, Brendan Lee, Heather Szabo-Rogers, Heather Szabo-Rogers, Heather Szabo-Rogers, Dobrawa Napierala, Dobrawa Napierala   +9 more
doaj   +1 more source

Targeting Chondroitin Sulphate Synthase 1 (Chsy1) Promotes Axon Growth Following Neurorrhaphy by Suppressing Versican Accumulation

Molecules, 2023
Versican is a chondroitin sulfate proteoglycan (CSPG), which deposits in perineurium as a physical barrier and prevents the growth of axons out of the fascial boundary.
Chiung-Hui Liu, Ying-Jui Ho, Che-Yu Wang, Chao-Chun Hsu, Yin-Hung Chu, Min-Yen Hsu, Shiu-Jau Chen, Wen-Chuan Hsiao, Wen-Chieh Liao   +8 more
doaj   +1 more source

The Role of NG2 Proteoglycan in Glioma

Translational Oncology, 2016
Neuron glia antigen-2 ((NG2), also known as chondroitin sulphate proteoglycan 4, or melanoma-associated chondroitin sulfate proteoglycan) is a type-1 membrane protein expressed by many central nervous system (CNS) cells during development and ...
Sridevi Yadavilli, Eugene I. Hwang, Roger J. Packer, Javad Nazarian   +3 more
doaj   +1 more source

Dietary Supplements for Arthritis and other Inflammatory Conditions: Key Role of Mast Cells and Benefit of Combining Anti-Inflammatory and Proteoglycan Products

European Journal of Inflammation, 2003
Arthritis is estimated to affect over 30% of all adults and all the available drugs add considerable morbidity and mortality of their own. A recent therapeutic approach targets the mast cells that are currently considered critical in a variety of ...
T. C. Theoharides
doaj   +1 more source

Immunotherapeutic Targeting of NG2/CSPG4 in Solid Organ Cancers

Vaccines, 2022
Neuro-glia antigen 2/chondroitin sulfate proteoglycan 4 (NG2/CSPG4, also called MCSP, HMW-MAA, MSK16, MCSPG, MEL-CSPG, or gp240) is a large cell-surface antigen and an unusual cell membrane integral glycoprotein frequently expressed on undifferentiated ...
Hongyu Zhang, Zhenyu Wu, Deyu Hu, Min Yan, Jing Sun, Jiejuan Lai, Lianhua Bai   +6 more
doaj   +1 more source

Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B

Cell Research, 2014
As a gram-positive, spore-forming anaerobic bacillus, Clostridium difficile (C. difficile) is responsible for severe and fatal pseudomembranous colitis, and poses the most urgent antibiotic resistance threat worldwide. Epidemic C.
Pengfei Yuan, Hongmin Zhang, Changzu Cai, Shiyou Zhu, Yuexin Zhou, Xiaozhou Yang, R. He, Chan Li, Shengjie Guo, Shan Li, Tuxiong Huang, G. Pérez-Cordón, H. Feng, Wensheng Wei   +13 more
semanticscholar   +1 more source

The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury

Journal of Neuroinflammation, 2012
Background Chondroitin sulfate proteoglycans are major inhibitory molecules for neural plasticity under both physiological and pathological conditions. The chondroitin sulfate degrading enzyme chondroitinase ABC promotes functional recovery after spinal ...
Tauchi Ryoji, Imagama Shiro, Natori Takamitsu, Ohgomori Tomohiro, Muramoto Akio, Shinjo Ryuichi, Matsuyama Yukihiro, Ishiguro Naoki, Kadomatsu Kenji   +8 more
doaj   +1 more source

An Overview of in vivo Functions of Chondroitin Sulfate and Dermatan Sulfate Revealed by Their Deficient Mice

Frontiers in Cell and Developmental Biology, 2021
Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) are covalently attached to specific core proteins to form proteoglycans in their biosynthetic pathways.
Shuji Mizumoto, Shuhei Yamada
doaj   +1 more source

Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells

Journal of Immunotherapy for Cancer, 2014
BackgroundThe development of immunotherapy has led to significant progress in the treatment of metastatic cancer, including the development of genetic engineering technologies that redirect lymphocytes to recognize and target a wide variety of tumor ...
R. Beard, Zhili Zheng, Kiran H. Lagisetty, W. Burns, E. Tran, S. Hewitt, Daniel Abate-Daga, Shannon F. Rosati, H. Fine, S. Ferrone, S. Rosenberg, R. Morgan   +11 more
semanticscholar   +1 more source

The role of aggrecan in normal and osteoarthritic cartilage

Journal of Experimental Orthopaedics, 2014
Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads.
Peter J Roughley, John S Mort
doaj   +1 more source