Results 41 to 50 of about 43,424 (239)

Expanding the Chondroitin Sulfate Glycoproteome — But How Far?

Frontiers in Cell and Developmental Biology, 2021
Chondroitin sulfate proteoglycans (CSPGs) are found at cell surfaces and in connective tissues, where they interact with a multitude of proteins involved in various pathophysiological processes.
Fredrik Noborn, Mahnaz Nikpour, Andrea Persson, Jonas Nilsson, Jonas Nilsson, Göran Larson   +5 more
doaj   +1 more source

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Journal of Neuroscience, 2014
Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via lentiviral vector (LV-ChABC) to explore the consequences of large-scale CSPG ...
K. Bartus, N. James, A. Didangelos, K. Bosch, J. Verhaagen, Rafael J. Yáñez-Muñoz, J. Rogers, B. Schneider, E. Muir, E. Bradbury   +9 more
semanticscholar   +1 more source

Histopathologic and immunohistochemical features of capsular tissue around failed Ahmed glaucoma valves. [PDF]

PLoS ONE, 2017
Impervious encapsulation around Ahmed glaucoma valve (AGV) results in surgical failure raising intraocular pressure (IOP). Dysregulation of extracellular matrix (ECM) molecules and cellular factors might contribute to increased hydraulic resistance to ...
Alka Mahale, Fatma Fikri, Khitam Al Hati, Sami Al Shahwan, Ibrahim Al Jadaan, Hind Al Katan, Rajiv Khandekar, Azza Maktabi, Deepak P Edward   +8 more
doaj   +1 more source

Endothelial Cells Angiogenesis in Sulfated Glycosaminoglycan (GAG) Hydrogels Enhanced by Bioactive Glass‐Released Ions

Advanced Functional Materials, EarlyView.
A mechanically tunable hydrogel composed of gelatin, chondroitin sulfate and laminin promotes angiogenesis in vitro without the supplement of growth factors. Endothelial cells morphogenesis was further enhanced by medium conditioned with bioactive glass 58S‐released ions (Ca and Si), thus offering a promising strategy to vascularize 3D tissue ...
Marco Piazzoni, Ilaria Borghi, Francesca Cadamuro, Sophia Dalfino, Riccardo Campanile, Sofia Nizzolo, Valeria Cassina, Francesca Tallia, Julian R. Jones, Francesco Mantegazza, Sabrina Bertini, Lorenzo Moroni, Francesco Nicotra, Laura Russo   +13 more
wiley   +1 more source

Silencing of Carbohydrate Sulfotransferase 15 Hinders Murine Pulmonary Fibrosis Development

Molecular Therapy: Nucleic Acids, 2017
Pulmonary fibrosis is a progressive lung disorder characterized by interstitial fibrosis, for which no effective treatments are available. Chondroitin sulfate proteoglycan (CSPG) has been shown to be a mediator, but the specific component of ...
Yoshiro Kai, Koichi Tomoda, Hiroyuki Yoneyama, Masahiro Kitabatake, Atsuhiro Nakamura, Toshihiro Ito, Masanori Yoshikawa, Hiroshi Kimura   +7 more
doaj   +1 more source

Biglycan regulated colorectal cancer progress by modulating enteric neuron-derived IL-10 and abundance of Bacteroides thetaiotaomicron

iScience, 2023
Summary: Biglycan (BGN) is a proteoglycan with branch chains and highly expressed in enteric neurons in the tumor tissue of colorectal cancer (CRC), which is negatively associated with survival rates in patients with CRC.
Yuyu Xu, Fei Wang, Kai Mi, Xinyuan Wang, Danlei Wang, Qing Zhao, Jingjing Wang, Zhi Liu, Qingqing Zhang, Yang Liu, Xuemei Zhang, Xingyin Liu   +11 more
doaj   +1 more source

PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

Science, 2009
Toward Neuronal Regeneration Neurons in the central nervous system that are severed or crushed do not regenerate well. Part of the problem derives from the glial scars left behind after such damage.
Yingjie Shen, Alan P. Tenney, S. Busch, K. Horn, Fernando X. Cuascut, Kai-Fenp Liu, Zhigang He, J. Silver, J. Flanagan   +8 more
semanticscholar   +1 more source

The Space Within: How Architected Voids Promote Tissue Formation

Advanced Materials, EarlyView.
This review explores the role of void spaces in tissue engineering scaffolds and examines four key methods for introducing porosity into hydrogels at different scales. It discusses sacrificial templating, microgels, phase separation, and 3D printing, highlighting principles, advantages, and limitations. It also addresses emerging strategies integrating
Anna Puiggalí‐Jou, Isabel B. Hui, Carla Fernandez‐Rico, Marcy Zenobi‐Wong   +3 more
wiley   +1 more source

Neuroendocrine tumors show altered expression of chondroitin sulfate, glypican 1, glypican 5 and syndecan 2 depending on their differentiation grade

Frontiers in Oncology, 2014
Neuroendocrine tumors are found throughout the body and are important as they give rise to distinct clinical syndromes. Glycosaminoglycans, in proteoglycan form or as free chains, play vital roles in every step of tumor progression.
Olivia eGarcía-Suárez, Beatriz eGarcía, Iván eFernández-Vega, Aurora eAstudillo, Aurora eAstudillo, Luis M Quirós, Luis M Quirós   +6 more
doaj   +1 more source

Endothelial glycocalyx degradation during sepsis: Causes and consequences

Matrix Biology Plus, 2021
The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the vascular lumen. It is enriched in proteoglycans, which are proteins attached to the glycosaminoglycans heparan sulfate, chondroitin sulfate, dermatan sulfate ...
Ryan C. Sullivan, Matthew D. Rockstrom, Eric P. Schmidt, Joseph A. Hippensteel   +3 more
doaj   +1 more source