Results 41 to 50 of about 54,015 (281)

Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components. [PDF]

, 2013
Background Proteases expressed in atherosclerotic plaque lesions generate collagen fragments, release glycosaminoglycans (chondroitin sulfate [CS] and dermatan sulfate [DS]) and expose extracellular matrix (ECM) proteins (e.g.
Bóta, Attila, Kolev, K., Komorowicz, E., Longstaff, C., Machovich, R., Rottenberger, Z., Szabó, László, Varga, Zoltán   +7 more
core   +1 more source

Biosynthesis of the Chondroitin Sulfate Proteoglycan

Journal of Biological Chemistry, 1972
Abstract Xylosyltransferase from embryonic chick epiphyseal cartilage catalyzes the transfer of xylose from UDP-xylose to particulate endogenous acceptors or to an exogenous protein acceptor obtained by Smith degradation of bovine chondroitin sulfate-protein complex.
Allen C. Stoolmiller, Allen L. Horwitz, Albert Dorfman, Joseph P. Kennedy   +3 more
openaire   +3 more sources

Pattern of chondroitin sulfate proteoglycan expression after ablation of the sensorimotor cortex of the neonatal and adult rat brain [PDF]

Archives of Biological Sciences, 2008
The central nervous system has a limited capacity for self-repair after damage. However, the neonatal brain has agreater capacity for recovery than the adult brain.
Dacić Sanja, Peković Sanja, Stojiljković Maja T., Lavrnja Irena, Stojkov Danijela, Bjelobaba Ivana, Stojiljković Mirjana   +6 more
doaj   +1 more source

Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture

Nature Communications, 2017
Müller glia are a type of retinal glial cell important for maintaining retinal structure and implicated in response to retinal damage. Here the authors identify Brevican, a chondroitin sulfate proteoglycan, as a microRNA-modulated regulator of Müller ...
Stefanie G. Wohl, Nikolas L. Jorstad, Edward M. Levine, Thomas A. Reh   +3 more
doaj   +1 more source

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. [PDF]

, 2017
Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Esko, Jeffrey D, Ihse, Elisabet, Lawrence, Roger, Masliah, Eliezer, van Wijk, Xander M, Yamakado, Hodaka   +5 more
core   +2 more sources

Glypican-1, Phosphacan/Receptor Protein-Tyrosine Phosphatase-ζ/β and its Ligand, Tenascin-C, are Expressed by Neural Stem Cells and Neural Cells Derived from Embryonic Stem Cells

ASN Neuro, 2010
The heparan sulfate proteoglycan glypican-1, the chondroitin sulfate proteoglycan phosphacan/RPTP (receptor protein-tyrosine phosphatase)-ζ/β and the extracellular matrix protein tenascin-C were all found to be expressed by neural stem cells and by ...
Mary Abaskharoun, Marie Bellemare, Elizabeth Lau, Richard U Margolis   +3 more
doaj   +1 more source

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Journal of Neuroscience, 2014
Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via lentiviral vector (LV-ChABC) to explore the consequences of large-scale CSPG ...
K. Bartus, N. James, A. Didangelos, K. Bosch, J. Verhaagen, Rafael J. Yáñez-Muñoz, J. Rogers, B. Schneider, E. Muir, E. Bradbury   +9 more
semanticscholar   +1 more source

Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis [PDF]

, 2005
Experimental autoimmune encephalomyelitis (EAE) is an animal model of inflammatory demyelination, a pathological event common to multiple sclerosis (MS). During CNS inflammation there are alterations in the extracellular matrix (ECM).
A.K. Cross, Abbaszzade, Asher, Bandtlow, Barrett, Behi, Brew, Cal, Collins-Racie, D.J. Buttle, G. Haddock, Hartung, Hashimoto, Hill, Inatani, J. Plumb, J. Surr, Jaworski, Kashiwagi, Kashiwagi, Krekoski, Kuno, Kuno, Kurazono, Langton, Lindberg, Lo, Lukes, M.N. Woodroofe, Matthews, Muir, Novak, Novak, Ohgoh, Pangalos, Porter, R.A.D. Bunning, Rosenberg, Sandy, Sasaki, Satoh, Sobel, Somerville, Tang, Teesalu, Toft-Hansen, Vankemmelbeke, Vankemmelbeke, Vazquez, Yamaguchi, Yu, Yuan, Zuo   +52 more
core   +1 more source

Roles of Chondroitin Sulfate Proteoglycans as Regulators of Skeletal Development

Frontiers in Cell and Developmental Biology, 2022
The extracellular matrix (ECM) is critically important for most cellular processes including differentiation, morphogenesis, growth, survival and regeneration. The interplay between cells and the ECM often involves bidirectional signaling between ECM components and small molecules, i.e., growth factors, morphogens, hormones, etc., that regulate ...
Nancy B. Schwartz, Nancy B. Schwartz, Miriam S. Domowicz   +2 more
openaire   +3 more sources

Trps1 Regulates Development of Craniofacial Skeleton and Is Required for the Initiation of Palatal Shelves Fusion

Frontiers in Physiology, 2019
Trichorhinophalangeal syndrome (TRPS) is an autosomal dominant disorder resulting from heterozygous mutations of the TRPS1 gene. Common craniofacial abnormalities in TRPS patients include micrognathia, hypoplastic zygomatic arch, high-arched palate, and,
Kah Yan Cho, Brian P. Kelley, Brian P. Kelley, Daisy Monier, Brendan Lee, Heather Szabo-Rogers, Heather Szabo-Rogers, Heather Szabo-Rogers, Dobrawa Napierala, Dobrawa Napierala   +9 more
doaj   +1 more source