Results 51 to 60 of about 54,015 (281)
Effects of receptor clustering on ligand dissociation: Theory and simulations [PDF]
Biophys. J. 89 (2005) 3685, 2004 Receptor-ligand binding is a critical first step in signal transduction and the duration of the interaction can impact signal generation. In mammalian cells, clustering of receptors may be facilitated by heterogeneous zones of lipids, known as lipid rafts.
arxiv +1 more source
European Journal of Biochemistry, 1971 1 A proteoglycan containing about 80% chondroitin sulfate and dermatan sulfate in a ratio of 75:25 was isolated and purified from bovine arterial tissue. This proteoglycan behaved as a single compound by several criteria of homogeneity. On incubation in
H. Kresse, H. Heidel, E. Buddecke
semanticscholar +1 more source
Chondroitin sulfate proteoglycans in neural development and plasticity
Frontiers in Bioscience, 2010 PTPzeta and lectican family members are major chondroitin sulfate proteoglycans (CS-PGs) in the brain, which bind with many proteins via core protein and CS portions. Recent studies revealed that the oversulfated structures in CS constitute high affinity binding sites for various growth factors and axon guidance molecules, and play important roles in ...
Maki Ishii +2 more
openaire +3 more sources
Chondroitin Sulfate Proteoglycans in the Nervous System: Inhibitors to Repair [PDF]
BioMed Research International, 2014 Chondroitin sulfate proteoglycans (CSPGs) are widely expressed in the normal central nervous system, serving as guidance cues during development and modulating synaptic connections in the adult. With injury or disease, an increase in CSPG expression is commonly observed close to lesioned areas. However, these CSPG deposits form a substantial barrier to
Justin R. Siebert +2 more
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Isolation, characterization, and substrate properties of the external limiting membrane from the avian embryonic optic tectum [PDF]
, 1990 The external limiting membrane of the avian embryonic optic tectum is isolated by mechanically separating the neuronal mesencephalon from the overlying mesenchymal tissue.
Adler +58 more
core +1 more source
The Role of NG2 Proteoglycan in Glioma
Translational Oncology, 2016 Neuron glia antigen-2 ((NG2), also known as chondroitin sulphate proteoglycan 4, or melanoma-associated chondroitin sulfate proteoglycan) is a type-1 membrane protein expressed by many central nervous system (CNS) cells during development and ...
Sridevi Yadavilli +3 more
doaj +1 more source
Chondroitin Sulfate Proteoglycans and Neurotrophic Factors
Trends in Glycoscience and Glycotechnology, 2008 Fumiko Matsui
openaire +4 more sources
Molecules, 2023 Versican is a chondroitin sulfate proteoglycan (CSPG), which deposits in perineurium as a physical barrier and prevents the growth of axons out of the fascial boundary.
Chiung-Hui Liu +8 more
doaj +1 more source
Three-fold mechanism of inhibition of SARS-CoV-2 infection by the interaction of the spike glycoprotein with heparin [PDF]
arXiv, 2021 Heparin has been found to have antiviral activity against SARS-CoV-2. Here, by means of sliding window docking, molecular dynamics simulations and biochemical assays, we investigate the binding mode of heparin to the virus spike glycoprotein and the molecular basis for its antiviral activity.
arxiv
The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development [PDF]
Journal of Histochemistry & Cytochemistry, 2020 The orderly development of the nervous system is characterized by phases of cell proliferation and differentiation, neural migration, axonal outgrowth and synapse formation, and stabilization. Each of these processes is a result of the modulation of genetic programs by extracellular cues.
Panpan Yu +3 more
openaire +3 more sources