Results 71 to 80 of about 43,424 (239)

ROS‐Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF‐κB–LCN2 Inflammatory Feedback Loop

Advanced Science, EarlyView.
A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu, Yan Xu, Lang Qin, Zemin Ling, Yingjie Mai, Xiong Tian Guo, Jiajia Chen, Leping Yan, Lin Wang, Liming Bian, Fuxin Wei   +10 more
wiley   +1 more source

CSPG4-dependent cytotoxicity for C. difficile TcdB is influenced by extracellular calcium and chondroitin sulfate

mSphere
TcdB is an intracellular bacterial toxin indispensable to Clostridioides difficile infections. The ability to use chondroitin sulfate proteoglycan 4 (CSPG4) as a primary cell surface receptor is evolutionarily conserved by the two major variants of TcdB.
D. Annie Doyle, Paul L. DeAngelis, Jimmy D. Ballard   +2 more
doaj   +1 more source

Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury

Journal of Neuroscience, 1994
Injury to the adult mammalian CNS results in reactive changes among the glial cells surrounding the site of damage. Recently, an unusual class of glial cells has been identified within the intact adult rat cerebellum on the basis of the expression of the
J. Levine
semanticscholar   +1 more source

3D Hydrogel Cell Cultures and Their Biomedical Applications

Advanced NanoBiomed Research, EarlyView.
The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic‐Crook, Jeremy M. Crook, Brett Paull   +7 more
wiley   +1 more source

Chondroitin sulfate proteoglycans from salmon nasal cartilage inhibit angiogenesis

Biochemistry and Biophysics Reports, 2017
Because cartilage lacks nerves, blood vessels, and lymphatic vessels, it is thought to contain factors that inhibit the growth and development of those tissues.
Takashi Kobayashi, Ikuko Kakizaki, Hiroyuki Nozaka, Toshiya Nakamura   +3 more
doaj   +1 more source

Immunological characterization of a basement membrane-specific chondroitin sulfate proteoglycan

Journal of Cell Biology, 1989
Reichert's membrane, an extraembryonic membrane present in developing rodents, has been proposed as an in vivo model for the study of basement membranes. We have used this membrane as a source for isolation of basement membrane proteoglycans.
Kevin J. McCar, M. Accavitti
semanticscholar   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Interaction of the NG2 chondroitin sulfate proteoglycan with type VI collagen

Journal of Cell Biology, 1990
The NG2 chondroitin sulfate proteoglycan is a membrane-associated molecule of approximately 500 kD with a core glycoprotein of 300 kD. Both the complete proteoglycan and a smaller quantity of the 300-kD core are immunoprecipitable with polyclonal and ...
William B Staucup, Kimberlee J. Dahlin, Patricia Healy   +2 more
semanticscholar   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Endothelial Cell‐Specific Prolyl Hydroxylase‐2 Deficiency Augments Angiotensin II–Induced Arterial Stiffness and Cardiac Pericyte Recruitment in Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Endothelial prolyl hydroxylase‐2 (PHD2) is essential for pulmonary remodeling and hypertension. In the present study, we investigated the role of endothelial PHD2 in angiotensin II–mediated arterial stiffness, pericyte recruitment, and cardiac
Bo Liu, Heng Zeng, Han Su, Quinesha A. Williams, Jessie Besanson, Yingjie Chen, Jian‐Xiong Chen   +6 more
doaj   +1 more source