Results 81 to 90 of about 43,424 (239)

Three-dimensional culture of human meniscal cells: Extracellular matrix and proteoglycan production

BMC Biotechnology, 2008
Background The meniscus is a complex tissue whose cell biology has only recently begun to be explored. Published models rely upon initial culture in the presence of added growth factors. The aim of this study was to test a three-dimensional (3D) collagen
Norton H James, Ingram Jane A, Chow Yin, Mauerhan David, Gruber Helen E, Hanley Edward N, Sun Yubo   +6 more
doaj   +1 more source

Chondroitin sulfate proteoglycan CSPG4 as a novel hypoxia-sensitive marker in pancreatic tumors. [PDF]

PLoS ONE, 2014
CSPG4 marks pericytes, undifferentiated precursors and tumor cells. We assessed whether the shed ectodomain of CSPG4 (sCSPG4) might circulate and reflect potential changes in CSPG4 tissue expression (pCSPG4) due to desmoplastic and malignant aberrations ...
Shereen Keleg, Alexandr Titov, Anette Heller, Thomas Giese, Christine Tjaden, Sufian S Ahmad, Matthias M Gaida, Andrea S Bauer, Jens Werner, Nathalia A Giese   +9 more
doaj   +1 more source

Inhibition of neurite growth by the NG2 chondroitin sulfate proteoglycan

Journal of Neuroscience, 1994
The chondroitin sulfate proteoglycans (CSPGs) have been implicated as both positive and negative modulators of axonal growth; however, the functional properties of only a few specific CSPGs have been investigated.
CL Dou, J. Levine
semanticscholar   +1 more source

The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background The endocannabinoid system is a neuromodulatory system implicated in cellular processes during both development and regeneration. The Mexican axolotl, one of only a few vertebrates capable of central nervous system regeneration, was used to examine the role of the endocannabinoid system in the regeneration of the tail and spinal ...
Michael Tolentino, Sarah E. Walker, Gaynor E. Spencer, Robert Carlone   +3 more
wiley   +1 more source

The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth

Journal of Cell Biology, 1994
We have previously shown that aggregation of microbeads coated with N- CAM and Ng-CAM is inhibited by incubation with soluble neurocan, a chondroitin sulfate proteoglycan of brain, suggesting that neurocan binds to these cell adhesion molecules (Grumet ...
D. Friedlander, P. Milev, L. Karthikeyan, Renée K. Margolis, R. U. Margolis, M. Grumet   +5 more
semanticscholar   +1 more source

Ciprofloxacin Treatment in Juvenile Mice Involves Neuronal Activation and Mimics Physical Features of Human Disease

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Tendinopathy is a complex, painful condition that affects up to 5% of the general population in their lifetime. Antibiotic treatment with fluoroquinolones has been associated with the onset of tendinopathy and tendon rupture. The mechanisms behind fluoroquinolone induced tendinopathy remain unclear. To probe activation of potentially causative
Nicole A. Chittim, Amro A. Hussien, Nicolo Dubacher, Gabor Matyas, Jess G. Snedeker   +4 more
wiley   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Amphibian neural crest cell migration on purified extracellular matrix components: a chondroitin sulfate proteoglycan inhibits locomotion on fibronectin substrates

Journal of Cell Biology, 1987
The ability of purified extracellular matrix components to promote the initial migration of amphibian neural crest (NC) cells was quantitatively investigated in vitro.
R. Perris, S. Johansson
semanticscholar   +1 more source

Injectable Biomimetic Composite Hydrogel Scaffold With Tissue‐Engineered Cartilage Matrix for Articular Cartilage Regeneration

Rare Metals, EarlyView.
ABSTRACT Articular cartilage regeneration remains a significant challenge because of its limited intrinsic healing capacity and the inadequacy of conventional treatments for restoring structural and functional integrity. In this study, a novel injectable composite hydrogel scaffold was designed to mimic the extracellular matrix (ECM) of native ...
Zhong‐Lian Wu, Jun‐Jie Jiang, Hang Yao, Xian‐Feng Shang, Ming‐Di Zheng, Xu Hu, Shuo Xu, Jun‐Li Shi, Yan Han, Chi‐Run Wang, Qi Tao, Huai‐Guo Xue, Dong‐An Wang, Yu‐Chi Zhao   +13 more
wiley   +1 more source

Step‐Ladder Bioprinting to Align Collagen Fibers for Anisotropic Tissue Fabrication

Small, EarlyView.
The step‐ladder printing platform includes successive segments of channels with varying widths in a custom barrel design. This design allows for improved anisotropy of collagen fibers during extrusion. To demonstrate its effectiveness, corneal constructs with high transparency and shape fidelity, as well as articular cartilage constructs, displaying ...
Ilayda Namli, Yogendra Pratap Singh, Deepak Gupta, Syed Hasan Askari Rizvi, Yasar Ozer Yilmaz, Joao Vitor Silva Robazzi, Medine Dogan Sarikaya, Mehmet Baykara, Ibrahim T. Ozbolat   +8 more
wiley   +1 more source