Results 61 to 70 of about 10,804 (272)
Zdorovʹe Rebenka, 2018 Background. Juvenile rheumatoid arthritis (JRA) is a life-long pathological condition. Therefore, the study of the mechanisms of its development, the metabolic systems functioning, the formation of dystrophic changes on the background of the inflammatory
N.S. Shevchenko +4 more
doaj +1 more source
3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures
Advanced Science, EarlyView.This study developed a 3D brain vascular niche model that capture the key features of glioblastoma including perivascular infiltration, gene signature, dormancy and chemo resistance, by comparing 3D model with in vivo condition using identical glioma stem cells.
Vivian K. Lee +10 more
wiley +1 more source
Advanced Science, EarlyView.SeNSs provide a biocompatible, anti‐inflammatory UC therapy. SeNSs form protein coronas enriched with AKT/PI3K/NF‐κB pathway proteins, suppress GP130 via hydrophobic interactions, and inhibit pro‐inflammatory cytokines. In DSS‐induced UC mice, SeNSs reduce inflammation, tissue damage, and disease activity by modulating cytokine, chemokine, and ...
Dingyi Shen +5 more
wiley +1 more source
Chondroitin sulfate and joint disease
Osteoarthritis and Cartilage, 1998 Chondroitin sulfate is an important and major component of articular cartilage, where it occurs as part of the large proteoglycan, aggrecan. In the early stages of joint disease, both in animal models and in man, there are changes in chondroitin sulfate that affect the chain length and the pattern of sulfation.
openaire +3 more sources
Immunological Activity of Chondroitin Sulfate [PDF]
, 2006 Publisher Summary The use of chondroitin sulfate (CS) for the symptomatic treatment of osteoarthritis (OA) has become very popular; however, it has also been the subject of controversy for several reasons. First, the nutraceutical industry is less regulated than the pharmaceutical industry, and thus the nutraceutical CS often suffers from poor ...
Shinobu Sakai +3 more
openaire +3 more sources
Advanced Science, EarlyView.Cartilage injury is a prominent pathological hallmark of osteoarthritis. In this study, we developed a two‐modular hydrogel microparticle system wherein HMP‐A effectively targets the damaged area, while HMP‐B forms an efficient connection with HMP‐A on the cartilage surface.
Xinye Chen +5 more
wiley +1 more source
Promotion of spinal cord regeneration by neural stem cell-secreted trimerized cell adhesion molecule L1. [PDF]
PLoS ONE, 2012 The L1 cell adhesion molecule promotes neurite outgrowth and neuronal survival in homophilic and heterophilic interactions and enhances neurite outgrowth and neuronal survival homophilically, i.e. by self binding.
Xiaowen He +6 more
doaj +1 more source
Biohybrid Computing with Proteinoids and Algae
Advanced Science, EarlyView.We developed a novel biohybrid computing system by combining proteinoid microspheres with algae. The biological mixture creates spontaneous electrical oscillations. These oscillations can perform simple logic operations, such as AND, OR, NAND, and NOR gates. Environmental factors like temperature and pH affect how the system works.
Panagiotis Mougkogiannis +1 more
wiley +1 more source
Advanced Science, EarlyView.The filler‐barrier hydrogel system developed by dual‐network Janus structural strategy breaks through the difficulty of a single hydrogel to combine barrier protection with bone regeneration, and realizes the regeneration‐material degradation adaptation for the field of mandibular regeneration.
Yanhui Lu +14 more
wiley +1 more source
Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin
Journal of Inflammation, 2006 Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology.
Patsch Josef R +6 more
doaj +1 more source