Results 1 to 10 of about 56,482 (307)

Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis

Cell Death and Disease, 2021
Chondrosarcoma is a malignancy of soft tissue and bone that has a high propensity to metastasize to distant organs. Nerve growth factor (NGF) is critical for neuronal cell growth, apoptosis, and differentiation, and also appears to promote the ...
Huey-En Tzeng, Syuan-Ling Lin, Louis Anoop Thadevoos, Ming-Yu Lien, Wei-Hung Yang, Chih-Yuan Ko, Chih-Yang Lin, Yu-Wen Huang, Ju-Fang Liu, Yi-Chin Fong, Hsien-Te Chen, Chih-Hsin Tang   +11 more
doaj   +2 more sources

The utility of 18F-FDG PET and PET/CT in the diagnosis and staging of chondrosarcoma: a meta-analysis

Journal of Orthopaedic Surgery and Research, 2020
Objective Chondrosarcoma is the second most common primary bone sarcoma; however, unlike other tumors, the biopsy cannot easily make a definite diagnosis or predict the histological grade.
Qingyu Zhang, Yongming Xi, Dong Li, Zenong Yuan, Jun Dong   +4 more
doaj   +2 more sources

Testicular chondrosarcoma

Urology Annals, 2021
Only 5% of all urological tumors are accounted as Testicular tumors. Furthermore, a well differentiated chondrosarcoma of the testis is extremely rare. Thus, we are representing a rare case of testicular chondrosarcoma.
Abdulaziz Alhussaini, Mohammed Al Mansour, Noura Al Oudah, Khalid Al Rabeeah, Abdullah Al Khayal, Saad Abumelha   +5 more
doaj   +3 more sources

Therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target

Cell Communication and Signaling, 2019
Background Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, the inhibitor of CDK4 has been used ...
Zhengxiao Ouyang, Sisi Wang, Ming Zeng, Zhihong Li, Qing Zhang, Wanchun Wang, Tang Liu   +6 more
doaj   +2 more sources

Chondrosarcoma: A Clinical Review

Journal of Clinical Medicine, 2023
Chondrosarcomas are a diverse group of malignant cartilaginous matrix-producing neoplasms. Conventional chondrosarcomas are a continuum of disease based on the biologic activity of the tumor.
A. Gazendam, S. Popovic, N. Parasu, M. Ghert   +3 more
semanticscholar   +1 more source

EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression

eLife, 2023
Chondrosarcomas are primary cancers of cartilaginous tissue and capable of alteration to highly aggressive, metastatic, and treatment-refractory states, leading to a poor prognosis with a five-year survival rate at 11 months for dedifferentiated subtype.
Zong-Shin Lin, Chiao-Chen Chung, Yu-Chia Liu, Chu-Han Chang, Hui-Chia Liu, Yung-Yi Liang, Teng-Le Huang, Tsung-Ming Chen, Che-Hsin Lee, Chih-Hsin Tang, Mien-Chie Hung, Ya-Huey Chen   +11 more
doaj   +1 more source

Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma

Clinical Cancer Research, 2023
Purpose: Patients with unresectable/metastatic chondrosarcoma have poor prognoses; conventional chondrosarcoma is associated with a median progression-free survival (PFS) of
V. Subbiah, S. Chawla, A. Conley, B. Wilky, A. Tolcher, N. Lakhani, D. Berz, V. Andrianov, W. Crago, Monica Holcomb, Abrahim Hussain, C. Veldstra, J. Kalabus, Brianne O'Neill, Lane Senne, Emily Rowell, Analeah B Heidt, K. Willis, B. Eckelman   +18 more
semanticscholar   +1 more source

Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions

Cancers, 2023
Simple Summary This review article aims in describing the origins of chondrosarcoma radiation-resistance and proposes several potential solutions in order to improve the treatment, in regard with tumor grade and characteristics.
Antoine Gilbert, M. Tudor, Juliette Montanari, Kevin Commenchail, D. Savu, P. Lesueur, François Chevalier   +6 more
semanticscholar   +1 more source

High-Resolution Secretome Analysis of Chemical Hypoxia Treated Cells Identifies Putative Biomarkers of Chondrosarcoma

Proteomes, 2022
Chondrosarcoma is the second most common bone tumor, accounting for 20% of all cases. Little is known about the pathology and molecular mechanisms involved in the development and in the metastatic process of chondrosarcoma. As a consequence, there are no
Donatella Pia Spanò, Simone Bonelli, Matteo Calligaris, Anna Paola Carreca, Claudia Carcione, Giovanni Zito, Aldo Nicosia, Sergio Rizzo, Simone Dario Scilabra   +8 more
doaj   +1 more source

Classification of Chondrosarcoma: From Characteristic to Challenging Imaging Findings

Cancers, 2023
Simple Summary Chondrosarcomas are a very heterogeneous group of cartilage-forming tumors that comprise approximately one-third of all malignant bone tumors.
Jun-Ho Kim, S. Lee
semanticscholar   +1 more source