CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression [PDF]
Molecular Cancer, 2010 Background Chondrosarcoma is a disease that does not respond to conventional cytotoxic chemotherapy and expression of MMP1 is a marker for a poor prognosis. The mechanism of increased MMP1 expression in chondrosarcoma is not completely known. Our goal is
Chen Qian +3 more
doaj +4 more sources
Gadd45β expression in chondrosarcoma: A pilot study for diagnostic and biological implications in histological grading [PDF]
Diagnostic Pathology, 2010 Background Although the diagnosis of chondrosarcoma, especially the distinction between enchondroma and low-grade chondrosarcoma or low-grade chondrosarcoma and high-grade chondrosarcoma, is pathologically difficult, differential diagnosis is very ...
Ishido Yasuhiro +8 more
doaj +5 more sources
The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells
BMC Cancer, 2011 Background Chondrosarcoma is virtually resistant to chemotherapy and radiation therapy. Survivin, the smallest member of the inhibitor of apoptosis protein family, is a critical factor for tumor progression and resistance to conventional therapeutic ...
Grifka Joachim +6 more
doaj +6 more sources
Biomarkers of chondrosarcoma [PDF]
Journal of Clinical Pathology, 2018 Clinical outcome prediction is major concern to patients with cancer. Various molecular markers in various carcinomas have been identified in the past few decades.
Wonju Jeong, Ha-Jeong Kim
semanticscholar +4 more sources
Cell Communication and Signaling, 2019 Background Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, the inhibitor of CDK4 has been used ...
Zhengxiao Ouyang +6 more
doaj +2 more sources
BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors [PDF]
BMC Cancer, 2012 Background As major regulators of normal chondrogenesis, the bone morphogenic protein (BMP) and transforming growth factor β (TGFB) signaling pathways may be involved in the development and progression of central chondrosarcoma. In order to uncover their
Boeuf Stephane +6 more
doaj +2 more sources
Mesenchymal Chondrosarcoma of the Mandible, a Big Dilemma: Report of a Rare Case in Mesenchymal Chondrosarcoma of the Mandible—Report of a Case With Discussion of Diagnostic and Therapeutic Dilemmas [PDF]
Case Reports in DentistryChondrosarcomas are a group of malignant neoplasms with cartilaginous matrix production mostly found in flat and peripheral long bones. Mesenchymal chondrosarcoma is one of the most unusual and rare histological variants of chondrosarcoma, with a ...
Abbas Karimi +4 more
doaj +2 more sources
Inhibition of chondrosarcoma growth by mTOR inhibitor in an in vivo syngeneic rat model. [PDF]
PLoS ONE, 2012 BACKGROUND: Chondrosarcomas are the second most frequent primary malignant type of bone tumor. No effective systemic treatment has been identified in advanced or adjuvant phases for chondrosarcoma.
Jennifer Perez +7 more
doaj +6 more sources
Chondrosarcoma: A Clinical Review
Journal of Clinical Medicine, 2023 Chondrosarcomas are a diverse group of malignant cartilaginous matrix-producing neoplasms. Conventional chondrosarcomas are a continuum of disease based on the biologic activity of the tumor.
A. Gazendam +3 more
semanticscholar +1 more source
EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression
eLife, 2023 Chondrosarcomas are primary cancers of cartilaginous tissue and capable of alteration to highly aggressive, metastatic, and treatment-refractory states, leading to a poor prognosis with a five-year survival rate at 11 months for dedifferentiated subtype.
Zong-Shin Lin +11 more
doaj +1 more source