Results 21 to 30 of about 38,056 (264)

Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Safety and Clinical Activity in Patients With Advanced Chondrosarcoma.

open access: yesJournal of Clinical Oncology, 2020
PURPOSE Surgery is the primary therapy for localized chondrosarcoma; for locally advanced and/or metastatic disease, no known effective systemic therapy exists.
W. Tap   +16 more
semanticscholar   +1 more source

Is Chemotherapy Associated with Improved Overall Survival in Patients with Dedifferentiated Chondrosarcoma? A SEER Database Analysis

open access: yesClinical Orthopaedics and Related Research, 2021
Background Dedifferentiated chondrosarcoma is a chondrosarcoma subtype associated with high rates of recurrence and a poor prognosis. Others have proposed treatment of dedifferentiated chondrosarcoma using osteosarcoma protocols, including perioperative ...
L. Cranmer   +10 more
semanticscholar   +1 more source

Survival and Prognosis of Chondrosarcoma Subtypes: SEER Database Analysis

open access: yesJournal of Orthopaedic Research, 2020
Chondrosarcomas are rare tumors and, historically, investigation of these tumors has been limited to small series and single‐institution studies. There have been no studies that evaluated the identification or comparison of differences in prognostic ...
Kamil M. Amer   +4 more
semanticscholar   +1 more source

Mesenchymal chondrosarcoma of the mandible: A case report

open access: yesJournal of Craniomaxillofacial Research, 2021
Mesenchymal chondrosarcoma as an aggressive type of chondrosarcoma shows a characteristic biphasic histopathologic pattern. The head and neck region is included a high proportion of extra skeletal sites. Very rare examples of Mesenchymal Chondrosarcoma
Samira Derakhshan   +3 more
doaj   +1 more source

Chondrosarcoma of the Thorax [PDF]

open access: yesSarcoma, 2011
Although a rare entity, chondrosarcoma is the most common malignant tumor of the chest wall. Most patients present with an enlarging, painful anterior chest wall mass arising from the costochondrosternal junction. CT scan with intravenous contrast is the gold standard radiographic study for diagnosis and operative planning. Contrary to previous dictum,
W. Roy Smythe   +2 more
openaire   +2 more sources

GANT-61 induces cell cycle resting and autophagy by down-regulating RNAP III signal pathway and tRNA-Gly-CCC synthesis to combate chondrosarcoma

open access: yesCell Death and Disease, 2023
Chondrosarcoma is ineffective for conventional radiotherapy and chemotherapy with a poor prognosis. Hedgehog (Hh) signal pathway plays a crucial role in tumor growth and progression, which is constitutive activated in chondrosarcoma.
Yifeng Sun   +4 more
doaj   +1 more source

Imaging of chondrosarcomas [PDF]

open access: yesCancer Imaging, 2003
Chondrosarcoma is the commonest primary sarcoma of bone in adults, with a male predominance. Patients are usually between 30 and 70 years old. Clinical symptoms are pain and tenderness with or without a mass, the average duration of symptoms being 1-2 years, but growth may be very slow, especially for pelvic tumours.
L. Ollivier, J. Leclere, Daniel Vanel
openaire   +3 more sources

CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression

open access: yesMolecular Cancer, 2010
Background Chondrosarcoma is a disease that does not respond to conventional cytotoxic chemotherapy and expression of MMP1 is a marker for a poor prognosis. The mechanism of increased MMP1 expression in chondrosarcoma is not completely known. Our goal is
Chen Qian   +3 more
doaj   +1 more source

Dedifferentiated Chondrosarcoma

open access: yesDefinitions, 2020
The term dedifferentiated chondrosarcoma has been applied to tumors in which a well differentiated cartilaginous component, sometimes of demonstrably long duration, is associated with a less differentiated non-cartilaginous component that is assumed to ...
Andy Langdown
semanticscholar   +1 more source

Chondrosarcoma of a rib

open access: yesInternational Journal of Surgery Case Reports, 2015
Chondrosarcoma of a rib is a very rare malignant tumor of the bone. Most patients were present with an enlarging painful anterior chest wall tumor. We present a case of an asymptomatic 29-years old female with a tumor size of 10cm×12cm on the left anterior chest wall involving the 8th rib.
Mima Maychet B. Sangma   +1 more
openaire   +3 more sources

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