Results 61 to 70 of about 38,056 (264)

Giant Chondrosarcoma of Proximal Humerus in an Adult Female Patient: A Case Report [PDF]

Malaysian Orthopaedic Journal, 2015
Chondrosarcoma is the third most common primary tumour of the bone, after myeloma and osteosarcoma. Most of the chondrosarcoma grow slowly and rarely metastasize, and they have an excellent prognosis after adequate surgery. However most of them are chemo
Ng CK, Azuhairy A, Tan LH, Nordin A
doaj   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Histological Type‐Specific Behavior in Sarcomas: Analysis of Head and Neck Cancer Registry of Japan

The Laryngoscope, EarlyView.
The nasal cavity and paranasal sinuses are the most common sites for sarcomas of the head and neck, and predominant histological type depended on the primary site. Objective The goal of this study was to better understand the epidemiology, clinical characteristics, and treatment outcomes of head and neck sarcomas using real‐world data from Japan ...
Kenya Kobayashi, Seiichi Yoshimoto, Koji Yamamura, Megumi Kitayama, Daisuke Kawakita, Ken‐Ichi Nibu, Kenji Kondo, Yuki Saito   +7 more
wiley   +1 more source

Predictors of the survival of patients with chondrosarcoma of bone and metastatic disease at diagnosis

Journal of Cancer, 2019
Purpose: Chondrosarcoma with metastatic disease has a very poor prognosis. However, the prognosis and potential prognostic factors of patients with primary chondrosarcoma of bone and metastasis at presentation have not been documented because of its ...
Zhan Wang, Genlian Chen, Xiaowei Chen, Xin Huang, Meng Liu, Wei-bo Pan, Xiaobo Yan, Nong Lin, Zhaoming Ye   +8 more
semanticscholar   +1 more source

Inhibition of chondrosarcoma growth by mTOR inhibitor in an in vivo syngeneic rat model. [PDF]

PLoS ONE, 2012
BACKGROUND: Chondrosarcomas are the second most frequent primary malignant type of bone tumor. No effective systemic treatment has been identified in advanced or adjuvant phases for chondrosarcoma.
Jennifer Perez, Anne Valérie Decouvelaere, Thomas Pointecouteau, Daniel Pissaloux, Jean Philippe Michot, Anthony Besse, Jean Yves Blay, Aurélie Dutour   +7 more
doaj   +1 more source

Chondrosarcoma: biology, genetics, and epigenetics

F1000Research, 2018
Chondrosarcomas constitute a heterogeneous group of primary bone cancers characterized by hyaline cartilaginous neoplastic tissue. They are the second most common primary bone malignancy.
W. Chow
semanticscholar   +1 more source

Apparent diffusion coefficient and arterial spin labeling perfusion of conventional chondrosarcoma in the parafalcine region: a case report

Radiology Case Reports, 2018
Intracranial chondrosarcoma is a very rare malignant tumor of the central nervous system, and is difficult to preoperatively distinguish from other tumors using conventional imaging techniques.
Daigo Kojima, MD, Takaaki Beppu, MD, Hiroaki Saura, MD, Yuichi Sato, MD, Shunrou Fujiwara, MD, Kuniaki Ogasawara, MD   +5 more
doaj   +1 more source

Real‐World Data Analysis of Genomic Alterations Detected by a Dual DNA–RNA Comprehensive Genomic Profiling Test

Cancer Science, EarlyView.
This study analyzed 1356 cases using GenMineTOP, Japan's first dual DNA–RNA CGP test, and identified oncogenic alterations in 91.5% of cases. The RNA panel detected 105 fusion events, including 11 NTRK fusions. Furthermore, the analysis clarified the independent effects of genomic abnormalities and cancer type on RNA expression, providing valuable ...
Kousuke Watanabe, Miho Ogawa, Aya Shinozaki‐Ushiku, Shuichi Tsutsumi, Kenji Tatsuno, Hiroyuki Aburatani, Hidenori Kage, Katsutoshi Oda   +7 more
wiley   +1 more source

Ossifying fibromyxoid tumours with lipomatous and cartilaginous differentiation: A diagnostic pitfall

Histopathology, Volume 86, Issue 6, Page 891-899, May 2025.
Six cases of ossifying fibromyxoid tumour with lipomatous and cartilaginous differentiation are presented. Even though the clinical presentation and immunoprofile of these cases are concordant with classic ossifying fibromyxoid tumour they may provide significant diagnostic difficulty, given the rarity of these histopathological findings.
Natálie Klubíčková, Steven Billings, Josephine K T Dermawan, Jeremy F Molligan, Karen Fritchie   +4 more
wiley   +1 more source

Description of the immune microenvironment of chondrosarcoma and contribution to progression

OncoImmunology, 2017
Chondrosarcoma (CHS) is a rare bone malignancy characterized by its resistance to conventional systemic and radiation therapies. Whether immunotherapy targeting immune checkpoints may be active in these tumors remains unknown.
François A. Simard, Iseulys Richert, Alexandra Vandermoeten, Anne-Valérie Decouvelaere, Jean-Philippe Michot, Christophe Caux, Jean-Yves Blay, Aurélie Dutour   +7 more
doaj   +1 more source