Results 81 to 90 of about 56,482 (307)

Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis

Diagnostic Pathology, 2012
Purpose To investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.
Liang Xiaohui, Wang Danying, Wang Yan, Zhou Zhiqiang, Zhang Juan, Li Jinsong   +5 more
doaj   +1 more source

Results of a prospective phase 2 study of pazopanib in patients with surgically unresectable or metastatic chondrosarcoma

Cancer, 2019
This single‐arm, multicenter, phase 2 study evaluated the safety and antitumor activity of pazopanib in patients with unresectable or metastatic conventional chondrosarcoma.
W. Chow, P. Frankel, C. Ruel, D. Araujo, M. Milhem, S. Okuno, L. Hartner, S. Undevia, A. Staddon   +8 more
semanticscholar   +1 more source

Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases [PDF]

, 2014
Background: The aim of the study was to evaluate the clinical and imaging features of extraskeletal myxoid chondrosarcoma (EMC) including initial presentation, recurrence, and metastases. Patients and methods.
Hornick, Jason L., Jagannathan, Jyothi P., Kapoor, Neena, Krajewski, Katherine M., Ramaiya, Nikhil H., Shah, Shaan H., Shinagare, Atul B.   +6 more
core   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Apparent diffusion coefficient and arterial spin labeling perfusion of conventional chondrosarcoma in the parafalcine region: a case report

Radiology Case Reports, 2018
Intracranial chondrosarcoma is a very rare malignant tumor of the central nervous system, and is difficult to preoperatively distinguish from other tumors using conventional imaging techniques.
Daigo Kojima, MD, Takaaki Beppu, MD, Hiroaki Saura, MD, Yuichi Sato, MD, Shunrou Fujiwara, MD, Kuniaki Ogasawara, MD   +5 more
doaj   +1 more source

Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma

Oncogene, 2019
Chondrosarcoma is the second most common malignant bone tumor. It is characterized by low vascularity and an abundant extracellular matrix, which confer these tumors resistance to chemotherapy and radiotherapy.
M. Nakagawa, F. Nakatani, Hironori Matsunaga, T. Seki, M. Endo, Y. Ogawara, Y. Machida, T. Katsumoto, Kazutsune Yamagata, Ayuna Hattori, Shuhei Fujita, Yukiko Aikawa, Takamasa Ishikawa, T. Soga, A. Kawai, H. Chuman, Nobuhiko Yokoyama, Suguru Fukushima, Kenichiro Yahiro, A. Kimura, E. Shimada, T. Hirose, T. Fujiwara, Nokitaka Setsu, Y. Matsumoto, Y. Iwamoto, Y. Nakashima, I. Kitabayashi   +27 more
semanticscholar   +1 more source

Is the IDH Mutation a Good Target for Chondrosarcoma Treatment?

Current Molecular Biology Reports, 2020
Chondrosarcomas are rare cancers of bone that arise from the malignant transformation of cells of chondrocytic lineage. They are known to be resistant to systemic cytotoxic chemotherapy and radiotherapy. The mainstay of management of localised disease is
E. Cojocaru, C. Wilding, Bodil Engelman, Paul H. Huang, Robin L. Jones   +4 more
semanticscholar   +1 more source

Metaplastic Carcinoma of the Left Breast with Extensive Chondroid Differentiation [PDF]

, 2011
Metaplastic breast carcinoma is very rare neoplasm which contains mixture of carcinomatous (epithelial) and sarcomatous (mesenchymal) elements in variable proportion. Metaplastic carcinoma with chondroid differentiation is even rarer.
Bohra, Ashish, Jagtap, Sunil V, Jain, Gaurav, Kanetkar, Sujata R, Nikumbh, Dhiraj B   +4 more
core   +1 more source

Fibrosarcoma on the leg of an adult rhesus macaque (Macaca mulatta)

Veterinary Record Case Reports, EarlyView.
Abstract This case describes a fibrosarcoma on the left upper leg of an adult female rhesus macaque. The patient was initially presented with a defined swelling at the caudolateral side of the upper leg. Medially from the growth, a swollen circular wound had formed with a fistula leading in the direction of the mass.
Merel Wegman, Nadiah M. H. A. van Eijk, Jaco Bakker, Judith M. A. van den Brand, Jan A. M. Langermans   +4 more
wiley   +1 more source

Resistin facilitates VEGF-A-dependent angiogenesis by inhibiting miR-16-5p in human chondrosarcoma cells

Cell Death and Disease, 2019
Resistin is an adipokine that is associated with obesity, inflammation, and various cancers. Chondrosarcomas are primary malignant bone tumors that have a poor prognosis.
Shiou-Sheng Chen, Chih-Hsin Tang, Meng-Ju Chie, Chun-Hao Tsai, Y. Fong, Yung-Chang Lu, Wei‐Cheng Chen, Cheng-Ta Lai, Chuan-Yen Wei, H. Tai, Wen-Yi Chou, Shih-Wei Wang   +11 more
semanticscholar   +1 more source