Results 51 to 60 of about 22,213 (195)

BRD9 inhibition as potential treatment option for testicular germ cell tumors

Andrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen, Christine Sanders, Florian Fronhoffs, Kai Funke, Glen Kristiansen, Hubert Schorle   +5 more
wiley   +1 more source

Intra-operative cytodiagnosis of primary ovarian choriocarcinoma with Ki67 immunoexpression

Journal of Cytology, 2015
Primary ovarian choriocarcinoma is a rare neoplasm that can be gestational and non-gestational in origin. It accounts for one in 369 million pregnancies. Both types present with similar clinical, histomorphological and ultrastructural findings.
Asaranti Kar, Tushar Kar, Smita Mahapatra, Priyadarshini Dehuri   +3 more
doaj   +1 more source

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source

A case of intraplacental gestational choriocarcinoma; characterised by the methylation pattern of the early placenta and an absence of driver mutations

BMC Cancer, 2019
Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemotherapy for over 50 years. To
P. Savage, D. Monk, J. R. Hernández Mora, N. van der Westhuizen, J. Rauw, A. Tinker, W. Robinson, Qianqian Song, M. Seckl, R. Fisher   +9 more
semanticscholar   +1 more source

A case of complete remission of intractable gestational choriocarcinoma with subsequent chemotherapy after pembrolizumab

Taiwanese Journal of Obstetrics & Gynecology, 2023
Objective: Gestational choriocarcinoma is a gestational trophoblastic neoplasia (GTN) that originates from abnormal trophoblast proliferation. Although chemotherapy is effective for choriocarcinoma, personalized treatment becomes essential when patients ...
Kaoru Niimi, Eiko Yamamoto, Yukari Oda, Yuki Nishiko, Mayu Shibata, Kimihiro Nishino, Hiroaki Kajiyama   +6 more
doaj   +1 more source

Precision Oncology for Pediatric Solid Tumors Using In‐Hospital Pediatric/AYA Malignancy‐Specific Panel Sequencing

Cancer Science, EarlyView.
Our findings indicate that a pediatric/AYA‐specific targeted panel deployed in a hospital can deliver rapid, clinically actionable molecular insights with high diagnostic and prognostic yield. This complements larger sequencing platforms by offering speed, focused content, and easier interpretation.
Masato Kojima, Sho Kurihara, Isamu Saeki, Ryo Touge, Keigo Nakashima, Shuhei Karakawa, Fumiyuki Yamasaki, Satoshi Okada, Eiso Hiyama   +8 more
wiley   +1 more source

A Successfully Treated Multiple Metastatic Choriocarcinoma Coexistent With Live Fetus: A Case Report and Literature Review

Frontiers in Oncology, 2022
Management of metastatic choriocarcinoma coexistent with live fetus is tricky for gynecologists. There is no consensus on treatment because of its rarity.
Wei Ding, Wei Ding, Na Zhang, Yang Rao, Xiaoning Xu, Tonggang Nie, Pengpeng Qu, Pengpeng Qu   +7 more
doaj   +1 more source

Primary gastric choriocarcinoma

Revista Española de Enfermedades Digestivas, 2020
Choriocarcinomas are epitelial tumors with a rapidly growing rate and widely metastatic tumor of trophoblastic cells. Incidence have been reported 1 in 24,096 pregnant patients. Most cases arise in the uterus following gestational events. It can also be gonadal or extragonadal.
Katia, Picazo Ferrera, Miguel Ángel, Herrera Servin, Angélica I, Hernández Guerrero   +2 more
openaire   +2 more sources

Differential effect of lead and cadmium on mitochondrial function and NLRP3 inflammasome activation in human trophoblast

The Journal of Physiology, EarlyView.
Abstract figure legend The human placenta not only detects the presence of Pb and Cd but also carries hypoxia and inflammatory risks, which are associated with pregnancy complications. To understand the impact of these factors on the placental trophoblast, we evaluated the effect of Pb and Cd on mitochondrial function and the NLRP3 inflammasome in ...
Yifeng Dai, Xijin Xu, Xia Huo, Joost H. N. Schuitemaker, Marijke M. Faas   +4 more
wiley   +1 more source

Primary hepatic choriocarcinoma: a rare cause of spontaneous haemoperitoneum in an adult

Clinics and Practice, 2012
Choriocarcinoma is a beta human chorionic gonadotrophin secreting neoplasm pertinent to uterus and pregnancy mostly. It occurs primarily in gonads but rarely in extragonadal sites. Primary hepatic choriocarcinoma is an extremely rare tumor.
Girish D. Bakhshi, Ashok D. Borisa, Ajay H. Bhanadarwar, Mukund B. Tayade, Rajesh B. Yadav, Yogesh R. Jadhav   +5 more
doaj   +1 more source