Results 61 to 70 of about 22,213 (195)

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Short tandem repeats genotyping of gestational choriocarcinoma – our experiences

Taiwanese Journal of Obstetrics & Gynecology
Objective: This short communication demonstrates how short tandem repeat genotyping can identify the origin of gestational choriocarcinoma. Materials and methods: The origin of gestational choriocarcinoma in our three cases was determined using the short
Lajos Gergely, Vanda Repiska, Robert Petrovic, Miroslav Korbel, Ludovit Danihel, Jozef Sufliarsky, Michaela Kubickova, Helena Gbelcova, Petra Priscakova   +8 more
doaj   +1 more source

A Rare Case of Metastatic Choriocarcinoma of Lung Origin

Case Reports in Pulmonology, 2017
Choriocarcinoma is part of the spectrum of gestational trophoblastic disease that occurs in women of reproductive age. Although the most common metastatic site of choriocarcinoma is the lung, primary pulmonary choriocarcinoma is rare. To diagnose primary
Parth Rali, Jianwu Xie, Grishma Rali, Mayur Rali, Jan Silverman, Khalid Malik   +5 more
doaj   +1 more source

Rare Case of Vallecular Hemangioma With Complete Regression in an Adult Patient

The Laryngoscope, Volume 136, Issue 2, Page 794-797, February 2026.
A rare case of spontaneous regression of a pedunculated vallecular hemangioma in a 55‐year‐old male is presented. Following an incisional biopsy, the lesion regressed completely within three weeks, confirmed by imaging and direct laryngoscopy. This case highlights an unusual clinical outcome and raises questions about the mechanisms underlying ...
Guilherme Reimann Agne, Gustavo Nunes Bento, Marcelo Belli, Camila Batista Rossi, Luciana Depiere Lanzarin, Daniel Cury Ogata, Renan Bezerra Lira, Leandro Luongo Matos, Luiz Paulo Kowalski   +8 more
wiley   +1 more source

Choriocarcinoma Syndrome: A Potentially Fatal Complication of Testicular Cancer

Case Reports in Oncological Medicine, 2019
Choriocarcinoma syndrome is a rare clinical entity with advanced, high volume choriocarcinomatous tumors and markedly elevated B-hCG (>50,000 IU/L).
Vicken Zeitjian, Waqas Arslan, Andres Borja-Alvarez, S. Amar   +3 more
semanticscholar   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Lapatinib Inhibits Amphiregulin-induced BeWo Choriocarcinoma Cell Proliferation by Reducing ERK1/2 and AKT Signaling Pathways

Anticancer Research, 2019
Background: Human choriocarcinoma is the most aggressive type of gestational trophoblastic neoplasia. The expression of epidermal growth factor receptor (EGFR) in choriocarcinomas is significantly higher than those of trophoblastic cells in healthy ...
L. V. Pires, Yuyin Yi, Jung-Chien Cheng, Lolita Schneider Pizzolato, E. Cordero, P. Leung, I. Brum   +6 more
semanticscholar   +1 more source

Giant testicular germ‐cell tumours—An analysis of relative incidence and clinical features based on a clinical case series and a survey of the literature

BJUI Compass, Volume 7, Issue 1, January 2026.
Abstract Objectives This work aimed to document four new cases with giant testicular germ cell tumour (GCT) and to evaluate their relative incidence and clinical characteristics based on a literature survey. Despite the well‐established trend over time towards declining tumour sizes in testicular GCTs, giant testicular tumours (>15 cm in diameter) are ...
Markus Angerer, Alexander C. Harms, Christian Wülfing, Klaus‐Peter Dieckmann   +3 more
wiley   +1 more source

Hemoptysis as primary manifestation in three women with choriocarcinoma with pulmonary metastasis: a case series

Journal of Medical Case Reports, 2017
Background Gestational choriocarcinoma is the most common gestational trophoblastic neoplasia; it is often secondary to hydatidiform mole, as well as to abortion, ectopic pregnancy, premature delivery, or term delivery. Approximately 60% of patients with
Wenping Zhang, Bao Liu, Jizhen Wu, Beibei Sun   +3 more
doaj   +1 more source

Postnatal determinants of testicular germ cell tumor by histological subtypes: The EPSAM1 and EPSAM2 studies

International Journal of Cancer, Volume 158, Issue 1, Page 108-119, 1 January 2026.
What's new? While several nongenetic risk factors are linked to testicular germ‐cell tumors (TGCTs), the influence of environmental and hormonal factors remains unclear. This study evaluated the role of postnatal exposures in the etiology of TGCT using data from the ongoing EPSAM case–control investigation in Italy.
Mauro Cioffi, Giovenale Moirano, Elena Isaevska, Valentina Fiano, Massimo Di Maio, Patrizia Lista, Ilaria Depetris, Andrea Zitella, Pietro Quaglino, Lorenzo Richiardi, Maja Popovic   +10 more
wiley   +1 more source