Results 41 to 50 of about 10,527 (218)

Biosensors for the detection of chorismate and cis,cis-muconic acid in Corynebacterium glutamicum

Journal of Industrial Microbiology & Biotechnology
Corynebacterium glutamicum ATCC 13032 is a promising microbial chassis for industrial production of valuable compounds, including aromatic amino acids derived from the shikimate pathway.
Jeanette C. Velasquez-Guzman, Herbert M Huttanus, Demosthenes P. Morales, Tara S Werner, Austin L Carroll, A. Guss, Chris M Yeager, Taraka T. Dale, Ramesh K. Jha   +8 more
semanticscholar   +1 more source

Sensor-Enabled Alleviation of Product Inhibition in Chorismate Pyruvate-Lyase.

ACS Synthetic Biology, 2019
Product inhibition is a frequent bottleneck in industrial enzymes, and testing mutations to alleviate product inhibition via traditional methods remains challenging as many variants need to be tested against multiple substrate and product concentrations.
R. Jha, N. Narayanan, Naresh Pandey, Jeremy M. Bingen, Theresa L. Kern, Christopher W. Johnson, C. Strauss, G. Beckham, S. Hennelly, Taraka T. Dale   +9 more
semanticscholar   +1 more source

Multi‐modular engineering of Saccharomyces cerevisiae for high‐titre production of tyrosol and salidroside

Microbial Biotechnology, 2021
Summary Tyrosol and its glycosylated product salidroside are important ingredients in pharmaceuticals, nutraceuticals and cosmetics. Despite the ability of Saccharomyces cerevisiae to naturally synthesize tyrosol, high yield from de novo synthesis ...
Huayi Liu, Yujuan Tian, Yi Zhou, Yeyi Kan, Tingting Wu, Wenhai Xiao, Yunzi Luo   +6 more
doaj   +1 more source

Brassicaceae-specific Gretchen Hagen 3 acyl acid amido synthetases conjugate amino acids to chorismate, a precursor of aromatic amino acids and salicylic acid

Journal of Biological Chemistry, 2019
To modulate responses to developmental or environmental cues, plants use Gretchen Hagen 3 (GH3) acyl acid amido synthetases to conjugate an amino acid to a plant hormone, a reaction that regulates free hormone concentration and downstream responses.
C. Holland, C. Westfall, J. Schaffer, Alejandro De Santiago, C. Zubieta, S. Alvarez, J. Jez   +6 more
semanticscholar   +1 more source

Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Advanced Science, EarlyView.
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman, Paul de Figueiredo, Arum Han   +11 more
wiley   +1 more source

Salicylate UV-Filters in Sunscreen Formulations Compromise the Preservative System Efficacy against Pseudomonas aeruginosa and Burkholderia cepacia

Cosmetics, 2020
Contamination of personal-care products are a serious health concern and therefore, preservative solutions are necessary for the costumers’ safety. High sun protection factor (SPF) sunscreen formulations are known to be difficult to preserve, due to ...
Noa Ziklo, Inbal Tzafrir, Regina Shulkin, Paul Salama   +3 more
doaj   +1 more source

The Mitogen‐Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis‐Immunity Trade‐Off in Cotton by Regulating Salicylic Acid Biosynthesis

Advanced Science, EarlyView.
AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia, Jingshang Wen, Jihang Li, Meina Feng, Yiming He, Ruojun Liu, Qian Liu, Junli Zhang, Kai Cheng, Xiangyu Zhang, Xiao Zhang   +10 more
wiley   +1 more source

Abyssomicins—A 20-Year Retrospective View

Marine Drugs, 2021
Abyssomicins represent a new family of polycyclic macrolactones. The first described compounds of the abyssomicin family were abyssomicin B, C, atrop-C, and D, produced by the marine actinomycete strain Verrucosispora maris AB-18-032, which was isolated ...
Hans-Peter Fiedler
doaj   +1 more source

Machine Learning Interatomic Potentials for Energy Materials: Architectures, Training Strategies, and Applications

Advanced Energy Materials, EarlyView.
Machine learning interatomic potentials bridge quantum accuracy and computational efficiency for materials discovery. Architectures from Gaussian process regression to equivariant graph neural networks, training strategies including active learning and foundation models, and applications in solid‐state electrolytes, batteries, electrocatalysts ...
In Kee Park, Saeed Pourasad, Jinhong Mun, Arunkumar Chitteth Rajan, Tae Hyeon Park, Anand Rohit, Mohammad Zafari, Tan‐Lien Pham, Eunjae Jung, Bonseung Koo, Miran Ha, Gi Beom Sim, Hyun Gyu Park, Won Woong Choi, Kwanghyeon Jo, Soohaeng Yoo Willow, David ChangMo Yang, Chang Woo Myung, Geunsik Lee, Kwang S. Kim   +19 more
wiley   +1 more source

Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor

Scientific Reports, 2019
The shikimate pathway, a metabolic pathway absent in humans, is responsible for the production of chorismate, a branch point metabolite. In the malaria parasite, chorismate is postulated to be a direct precursor in the synthesis of p-aminobenzoic acid ...
A. Valenciano, M. L. Fernández-Murga, E. Merino, Nicole R. Holderman, Grant J Butschek, Karl J. Shaffer, P. Tyler, M. Cassera   +7 more
semanticscholar   +1 more source