Results 1 to 10 of about 11,172 (138)

Metabolic Engineering of the Shikimate Pathway for Production of Aromatics and Derived Compounds—Present and Future Strain Construction Strategies [PDF]

Frontiers in Bioengineering and Biotechnology, 2018
The aromatic nature of shikimate pathway intermediates gives rise to a wealth of potential bio-replacements for commonly fossil fuel-derived aromatics, as well as naturally produced secondary metabolites.
Jens Krömer, Nils Averesch
exaly   +4 more sources

Increased Glyphosate-Induced Gene Expression in the Shikimate Pathway Is Abolished in the Presence of Aromatic Amino Acids and Mimicked by Shikimate. [PDF]

Front Plant Sci, 2020
The herbicide glyphosate inhibits the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) in the aromatic amino acid (AAA) biosynthetic pathway, also known as the shikimate pathway.
Zulet-González A, Barco-Antoñanzas M, Gil-Monreal M, Royuela M, Zabalza A.   +4 more
europepmc   +2 more sources

Functional characterization of two 3-dehydroquinases of AroQ1 and AroQ2 in the shikimate pathway and expression of genes for the type III secretion system in Ralstonia solanacearum. [PDF]

Front Microbiol, 2023
The shikimate pathway is a general route for the biosynthesis of aromatic amino acids (AAAs) in many microorganisms. A 3-dehydroquinase, AroQ, controls the third step of the shikimate pathway that catalyzes the formation of 3-dehydroquinate from 3 ...
Zhang Q, Wu B, Han L, Yu D, Liang T, Wang Y, Guo T.   +6 more
europepmc   +2 more sources

Computational modelling provides insight into the effects of glyphosate on the shikimate pathway in the human gut microbiome. [PDF]

Curr Res Toxicol, 2020
The herbicide active ingredient glyphosate can affect the growth of microorganisms, which rely on the shikimate pathway for aromatic amino acid biosynthesis.
Mesnage R, Antoniou MN.
europepmc   +2 more sources

Prime editing of an RR26-responsive cis-element enhances DAHPS2 expression and submergence tolerance in rice through the shikimate pathway. [PDF]

Plant Commun
Early postgermination growth is critical for uniform seedling emergence in direct-seeded rice; however, the underlying regulatory mechanisms remain unclear.
Chen D, Hou L, Qiu Z, Xu Q, Wang Q, Li M, Hao Z, Dong P, Zhang G, Hu J, Gao Z, Dong G, Ren D, Shen L, Rao Y, Li Q, Zhang Y, Zhang Q, Guo L, Shang L, Qian Q, Zhu L.   +21 more
europepmc   +2 more sources

Uncovering the Role of PhzC as DAHP Synthase in Shikimate Pathway of Pseudomonas chlororaphis HT66. [PDF]

Biology (Basel), 2022
DAHP synthase catalyzes the first step in the shikimate pathway, deriving the biosynthesis of aromatic amino acids (Trp, Phe and Tyr), phenazine-1-carboxamide, folic acid, and ubiquinone in Pseudomonas chlororaphis.
Wang S, Liu D, Bilal M, Wang W, Zhang X.
europepmc   +2 more sources

Mycobacterium tuberculosis Shikimate Pathway Enzymes as Targets for the Rational Design of Anti-Tuberculosis Drugs. [PDF]

Molecules, 2020
Roughly a third of the world’s population is estimated to have latent Mycobacterium tuberculosis infection, being at risk of developing active tuberculosis (TB) during their lifetime.
Nunes JES, Duque MA, de Freitas TF, Galina L, Timmers LFSM, Bizarro CV, Machado P, Basso LA, Ducati RG.   +8 more
europepmc   +2 more sources

Functional Analysis of 3-Dehydroquinate Dehydratase/Shikimate Dehydrogenases Involved in Shikimate Pathway in Camellia sinensis. [PDF]

Front Plant Sci, 2019
Polyphenols play an important role in the astringent taste of tea [Camellia sinensis (L.)] infusions; catechins in phenolic compounds are beneficial to health.
Huang K, Li M, Liu Y, Zhu M, Zhao G, Zhou Y, Zhang L, Wu Y, Dai X, Xia T, Gao L.   +10 more
europepmc   +2 more sources

CRISPR-mediated multigene integration enables Shikimate pathway refactoring for enhanced 2-phenylethanol biosynthesis in Kluyveromyces marxianus. [PDF]

Biotechnol Biofuels, 2021
Background 2-phenylethanol (2-PE) is a rose-scented flavor and fragrance compound that is used in food, beverages, and personal care products. Compatibility with gasoline also makes it a potential biofuel or fuel additive.
Li M, Lang X, Moran Cabrera M, De Keyser S, Sun X, Da Silva N, Wheeldon I.   +6 more
europepmc   +2 more sources

Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose-xylose co-substrate. [PDF]

Nat Commun, 2020
In lignocellulose biomass, microbes prefer consuming glucose over xylose, which affects target compound production. Here, the authors achieve simultaneous utilization of glucose and xylose for target chemical production and cell growth, respectively, and
Fujiwara R, Noda S, Tanaka T, Kondo A.
europepmc   +2 more sources