Computational modelling provides insight into the effects of glyphosate on the shikimate pathway in the human gut microbiome [PDF]
Current Research in Toxicology, 2020 The herbicide active ingredient glyphosate can affect the growth of microorganisms, which rely on the shikimate pathway for aromatic amino acid biosynthesis.
Robin Mesnage, Michael N. Antoniou
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Metabolic Engineering of the Shikimate Pathway for Production of Aromatics and Derived Compounds—Present and Future Strain Construction Strategies [PDF]
Frontiers in Bioengineering and Biotechnology, 2018 The aromatic nature of shikimate pathway intermediates gives rise to a wealth of potential bio-replacements for commonly fossil fuel-derived aromatics, as well as naturally produced secondary metabolites.
Nils J. H. Averesch, Jens O. Krömer
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Increased Glyphosate-Induced Gene Expression in the Shikimate Pathway Is Abolished in the Presence of Aromatic Amino Acids and Mimicked by Shikimate [PDF]
Frontiers in Plant Science, 2020 The herbicide glyphosate inhibits the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) in the aromatic amino acid (AAA) biosynthetic pathway, also known as the shikimate pathway.
Ainhoa Zulet-González +4 more
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SKPDB: a structural database of shikimate pathway enzymes [PDF]
BMC Bioinformatics, 2010 Background The functional and structural characterisation of enzymes that belong to microbial metabolic pathways is very important for structure-based drug design.
de Azevedo Walter F +7 more
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Functional characterization of two 3-dehydroquinases of AroQ1 and AroQ2 in the shikimate pathway and expression of genes for the type III secretion system in Ralstonia solanacearum [PDF]
Frontiers in Microbiology, 2023 The shikimate pathway is a general route for the biosynthesis of aromatic amino acids (AAAs) in many microorganisms. A 3-dehydroquinase, AroQ, controls the third step of the shikimate pathway that catalyzes the formation of 3-dehydroquinate from 3 ...
Qingshan Zhang +6 more
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Uncovering the Role of PhzC as DAHP Synthase in Shikimate Pathway of Pseudomonas chlororaphis HT66 [PDF]
Biology, 2022 DAHP synthase catalyzes the first step in the shikimate pathway, deriving the biosynthesis of aromatic amino acids (Trp, Phe and Tyr), phenazine-1-carboxamide, folic acid, and ubiquinone in Pseudomonas chlororaphis.
Songwei Wang +4 more
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Prime editing of an RR26-responsive cis-element enhances DAHPS2 expression and submergence tolerance in rice through the shikimate pathway [PDF]
Plant CommunicationsEarly postgermination growth is critical for uniform seedling emergence in direct-seeded rice; however, the underlying regulatory mechanisms remain unclear.
Dongdong Chen +21 more
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The shikimate pathway: gateway to metabolic diversity. [PDF]
Nat Prod RepThe shikimate pathway is the metabolic process responsible for the biosynthesis of proteinogenic, aromatic amino acids as well as a bevy of specialized metabolites in bacteria, fungi, and plants.
Shende VV, Bauman KD, Moore BS.
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Mycobacterium tuberculosis Shikimate Pathway Enzymes as Targets for the Rational Design of Anti-Tuberculosis Drugs [PDF]
Molecules, 2020 Roughly a third of the world’s population is estimated to have latent Mycobacterium tuberculosis infection, being at risk of developing active tuberculosis (TB) during their lifetime.
José E. S. Nunes +8 more
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CRISPR-mediated multigene integration enables Shikimate pathway refactoring for enhanced 2-phenylethanol biosynthesis in Kluyveromyces marxianus [PDF]
Biotechnology for Biofuels, 2021 Background 2-phenylethanol (2-PE) is a rose-scented flavor and fragrance compound that is used in food, beverages, and personal care products. Compatibility with gasoline also makes it a potential biofuel or fuel additive.
Mengwan Li +6 more
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