Results 31 to 40 of about 12,511 (215)

Shikimate Metabolic Pathway Engineering in Corynebacterium glutamicum

Journal of Microbiology and Biotechnology, 2021
Shikimate is a key high-demand metabolite for synthesizing valuable antiviral drugs, such as the anti-influenza drug, oseltamivir (Tamiflu). Microbial-based strategies for shikimate production have been developed to overcome the unstable and expensive supply of shikimate derived from traditional plant extraction processes.
Park, Eunhwi, Kim, Hye-Jin, Seo, Seung-Yeul, Lee, Han-Na, Choi, Si-Sun, Lee, Sang Joung, Kim, Eung-Soo   +6 more
openaire   +3 more sources

Evolutionary origins of the eukaryotic shikimate pathway : gene fusions, horizontal gene transfer, and endosymbiotic replacements [PDF]

, 2006
Currently the shikimate pathway is reported as a metabolic feature of prokaryotes, ascomycete fungi, apicomplexans, and plants. The plant shikimate pathway enzymes have similarities to prokaryote homologues and are largely active in chloroplasts ...
Blanchard, Jeffrey L, Roberts, C. W., Campbell, Samantha A, Blanchard, J. L., Roberts, Craig W, McLeod, R., P. G. Foster, Campbell, S. A., C. W. Roberts, R. McLeod, S. A. Campbell, Richards, Thomas A, J. L. Blanchard, Foster, Peter G, Dacks, J. B., Foster, P. G., T. A. Richards, Richards, T. A., J. B. Dacks, Dacks, Joel B, McLeod, Rima   +20 more
core   +1 more source

Targeted modulation of the shikimate pathway enhances bacterial wilt resistance through NbMEE32 suppression in tobacco

Industrial Crops and Products
The shikimate pathway serves as a central metabolic route for the biosynthesis of aromatic amino acids and diverse secondary metabolites involved in plant growth and defense.
Dong Cheng, Dan Zhou, Jiahui Wu, Bingsen Wang, Yuhan Li, Botao Song, Huilan Chen, Juan Du   +7 more
doaj   +1 more source

Targeting Shikimate Kinase Pathway of Acinetobacter baumannii: A Structure-Based Computational Approach to Identify Antibacterial Compounds

Journal of Tropical Medicine, 2023
Acinetobacter baumannii (A. baumannii) is an opportunistic bacterium that has developed multidrug resistance (MDR) to most of today’s antibiotics, posing a significant risk to human health.
Aparna Shil, Most. Afrin Akter, Arafin Sultana, Sajal Kumar Halder, Mahbubul Kabir Himel   +4 more
doaj   +1 more source

Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans

Life Science Alliance, 2022
Structural characterization of shikimate pathway multi-enzyme Aro1 from opportunistic fungal pathogen Candida albicans provides the first molecular image of all five domains.
Peter J Stogios, Sean D Liston, Cameron Semper, Bradley Quade, Karolina Michalska, Elena Evdokimova, Shane Ram, Zbyszek Otwinowski, Dominika Borek, Leah E Cowen, Alexei Savchenko   +10 more
doaj   +1 more source

The formation of homogentisate in the biosynthesis of tocopherol and plastoquinone in spinach chloroplasts [PDF]

, 1982
Homogentisate is the precursor in the biosynthesis of -tocopherol and plastoquinone-9 in chloroplasts. It is formed of 4-hydroxyphenylpyruvate of the shikimate pathway by the 4-hydroxyphenylpyruvate dioxygenase.
Soll, Jürgen, Jürgen Soll, Schultz, Gernot, Fiedler, Erich, Erich Fiedler, Gernot Schultz   +5 more
core   +1 more source

Quinate-enhanced glyphosate toxicity is related to the accumulation of quinate derivatives

Plant Stress
Glyphosate is the most widely used herbicide and works by inhibiting the enzyme 5-enolpyruvylshikimate 3-phosphate synthase (EPSPS) of the shikimate pathway, preventing the aromatic amino acid biosynthesis.
Ainhoa Zulet-Gonzalez, Miriam Gil-Monreal, Karin Gorzolka, Mercedes Royuela, Ana Zabalza   +4 more
doaj   +1 more source

Creation of a Shikimate Pathway Variant

, 2016
The competition between the Escherichia coli carbohydrate phosphotransferase system and 3-deoxy-d-arabino-heptulosonate 7-phosphate (DAHP) synthase for phosphoenolpyruvate limits the concentration and yield of natural products microbially synthesized via
K. M. Draths (2715604), J. W. Frost (2685595), Ningqing Ran (2715601)   +2 more
core   +1 more source

Unraveling Shikimate Dehydrogenase Inhibition by 6-Nitroquinazoline-2,4-diol and Its Impact on Soybean and Maize Growth

Agronomy
The shikimate pathway is crucial for the biosynthesis of aromatic amino acids in plants and represents a promising target for developing new herbicides.
Aline Marengoni Almeida, Josielle Abrahão, Flavio Augusto Vicente Seixas, Paulo Sergio Alves Bueno, Marco Aurélio Schüler de Oliveira, Larissa Fonseca Tomazini, Rodrigo Polimeni Constantin, Wanderley Dantas dos Santos, Rogério Marchiosi, Osvaldo Ferrarese-Filho   +9 more
doaj   +1 more source

Biosynthesis of Rifamycins (Ansamycins) and Microbial Production of Shikimate Pathway Precursors, Intermediates, and Metabolites

CHIMIA, 1985
Is the elucidation of biosynthetic pathways of academic interest only, or are there enough valuable spin-offs to make biogenetic studies attractive for a research laboratory in a pharmaceutical company?
Oreste Ghisalba
doaj   +1 more source