Results 31 to 40 of about 11,222 (183)

Physiological Approach to the Use of the Natural Compound Quinate in the Control of Sensitive and Resistant Papaver rhoeas

Plants, 2020
Quinate (1,3,4,5-tetrahydroxycyclohexanecarboxylate) is a compound synthesized in plants through a side-branch of the shikimate biosynthesis pathway, which is accumulated after glyphosate and acetolactate synthase inhibiting herbicides (ALS-inhibitors ...
Ana Zabalza, Ainhoa Zulet-González, Maria Barco-Antoñanzas, Mikel V. Eceiza, Miriam Gil-Monreal, Mercedes Royuela   +5 more
doaj   +1 more source

Targeted modulation of the shikimate pathway enhances bacterial wilt resistance through NbMEE32 suppression in tobacco

Industrial Crops and Products
The shikimate pathway serves as a central metabolic route for the biosynthesis of aromatic amino acids and diverse secondary metabolites involved in plant growth and defense.
Dong Cheng, Dan Zhou, Jiahui Wu, Bingsen Wang, Yuhan Li, Botao Song, Huilan Chen, Juan Du   +7 more
doaj   +1 more source

Quinate-enhanced glyphosate toxicity is related to the accumulation of quinate derivatives

Plant Stress
Glyphosate is the most widely used herbicide and works by inhibiting the enzyme 5-enolpyruvylshikimate 3-phosphate synthase (EPSPS) of the shikimate pathway, preventing the aromatic amino acid biosynthesis.
Ainhoa Zulet-Gonzalez, Miriam Gil-Monreal, Karin Gorzolka, Mercedes Royuela, Ana Zabalza   +4 more
doaj   +1 more source

Targeting Shikimate Kinase Pathway of Acinetobacter baumannii: A Structure-Based Computational Approach to Identify Antibacterial Compounds

Journal of Tropical Medicine, 2023
Acinetobacter baumannii (A. baumannii) is an opportunistic bacterium that has developed multidrug resistance (MDR) to most of today’s antibiotics, posing a significant risk to human health.
Aparna Shil, Most. Afrin Akter, Arafin Sultana, Sajal Kumar Halder, Mahbubul Kabir Himel   +4 more
doaj   +1 more source

Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans

Life Science Alliance, 2022
Structural characterization of shikimate pathway multi-enzyme Aro1 from opportunistic fungal pathogen Candida albicans provides the first molecular image of all five domains.
Peter J Stogios, Sean D Liston, Cameron Semper, Bradley Quade, Karolina Michalska, Elena Evdokimova, Shane Ram, Zbyszek Otwinowski, Dominika Borek, Leah E Cowen, Alexei Savchenko   +10 more
doaj   +1 more source

Unraveling Shikimate Dehydrogenase Inhibition by 6-Nitroquinazoline-2,4-diol and Its Impact on Soybean and Maize Growth

Agronomy
The shikimate pathway is crucial for the biosynthesis of aromatic amino acids in plants and represents a promising target for developing new herbicides.
Aline Marengoni Almeida, Josielle Abrahão, Flavio Augusto Vicente Seixas, Paulo Sergio Alves Bueno, Marco Aurélio Schüler de Oliveira, Larissa Fonseca Tomazini, Rodrigo Polimeni Constantin, Wanderley Dantas dos Santos, Rogério Marchiosi, Osvaldo Ferrarese-Filho   +9 more
doaj   +1 more source

Shikimate Metabolic Pathway Engineering in Corynebacterium glutamicum

Journal of Microbiology and Biotechnology, 2021
Shikimate is a key high-demand metabolite for synthesizing valuable antiviral drugs, such as the anti-influenza drug, oseltamivir (Tamiflu). Microbial-based strategies for shikimate production have been developed to overcome the unstable and expensive supply of shikimate derived from traditional plant extraction processes.
Park, Eunhwi, Kim, Hye-Jin, Seo, Seung-Yeul, Lee, Han-Na, Choi, Si-Sun, Lee, Sang Joung, Kim, Eung-Soo   +6 more
openaire   +3 more sources

Biosynthesis of Rifamycins (Ansamycins) and Microbial Production of Shikimate Pathway Precursors, Intermediates, and Metabolites

CHIMIA, 1985
Is the elucidation of biosynthetic pathways of academic interest only, or are there enough valuable spin-offs to make biogenetic studies attractive for a research laboratory in a pharmaceutical company?
Oreste Ghisalba
doaj   +1 more source

Natural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants

Advanced Science, EarlyView.
Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...
Yanli Wang, Wei Tong, Qiong Wu, Didi Wu, Yanrui Zhang, Qijuan Gao, Fangdong Li, Zhaoliang Zhang, Wenjie Wang, Chuankui Song, Enhua Xia   +10 more
wiley   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source