Results 21 to 30 of about 12,511 (215)

Pathway-based screening strategy for multitarget inhibitors of diverse proteins in metabolic pathways. [PDF]

PLoS Computational Biology, 2013
Many virtual screening methods have been developed for identifying single-target inhibitors based on the strategy of "one-disease, one-target, one-drug".
Kai-Cheng Hsu, Wen-Chi Cheng, Yen-Fu Chen, Wen-Ching Wang, Jinn-Moon Yang   +4 more
doaj   +1 more source

Targeting hydroxycinnamoyl CoA: shikimate hydroxycinnamoyl transferase for lignin modification in Brachypodium distachyon

Biotechnology for Biofuels, 2021
Background Hydroxycinnamoyl CoA: shikimate hydroxycinnamoyl transferase (HCT) is a central enzyme of the so-called “esters” pathway to monolignols. As originally envisioned, HCT functions twice in this pathway, to form coumaroyl shikimate and then, in ...
Juan Carlos Serrani-Yarce, Luis Escamilla-Trevino, Jaime Barros, Lina Gallego-Giraldo, Yunqiao Pu, Art Ragauskas, Richard A. Dixon   +6 more
doaj   +1 more source

Shikimate pathway in apicomplexan parasites [PDF]

Nature, 1999
The discovery of plastids in apicomplexan parasites1,3 raised the possibility that these organelles might harbour plastid-specific metabolic activities that could be blocked by therapeutic agents. Ideally, these agents would inhibit the parasites without harming their vertebrate hosts.
Patrick J. Keeling, Jeffrey D. Palmer, Robert G. K. Donald, David S. Roos, Ross F. Waller, Geoffrey I. McFadden   +5 more
openaire   +3 more sources

EPSP Synthase-Depleted Cells Are Aromatic Amino Acid Auxotrophs in Mycobacterium smegmatis

Microbiology Spectrum, 2021
The epidemiological importance of mycobacterial species is indisputable, and the necessity to find new molecules that can inhibit their growth is urgent.
Mario Alejandro Duque-Villegas, Bruno Lopes Abbadi, Paulo Ricardo Romero, Letícia Beatriz Matter, Luiza Galina, Pedro Ferrari Dalberto, Valnês da Silva Rodrigues-Junior, Rodrigo Gay Ducati, Candida Deves Roth, Raoní Scheibler Rambo, Eduardo Vieira de Souza, Marcia Alberton Perello, Héctor Ricardo Morbidoni, Pablo Machado, Luiz Augusto Basso, Cristiano Valim Bizarro   +15 more
doaj   +1 more source

Novel technologies combined with traditional metabolic engineering strategies facilitate the construction of shikimate-producing Escherichia coli

Microbial Cell Factories, 2017
Shikimate is an important intermediate in the aromatic amino acid pathway, which can be used as a promising building block for the synthesis of biological compounds, such as neuraminidase inhibitor Oseltamivir (Tamiflu®).
Pengfei Gu, Xiangyu Fan, Quanfeng Liang, Qingsheng Qi, Qiang Li   +4 more
doaj   +1 more source

Xylose and shikimate transporters facilitates microbial consortium as a chassis for benzylisoquinoline alkaloid production

Nature Communications, 2023
Plant-sourced aromatic amino acid (AAA) derivatives are a vast group of compounds with broad applications. Here, we present the development of a yeast consortium for efficient production of (S)-norcoclaurine, the key precursor for benzylisoquinoline ...
Meirong Gao, Yuxin Zhao, Zhanyi Yao, Qianhe Su, Payton Van Beek, Zengyi Shao   +5 more
doaj   +1 more source

Synergetic engineering of Escherichia coli for efficient production of l-tyrosine

Synthetic and Systems Biotechnology, 2023
l-Tyrosine, an aromatic non-essential amino acid, is the raw material for many important chemical products, including levodopa, resveratrol, and hydroxytyrosol. It is widely used in the food, drug, and chemical industries.
Jurong Ping, Lian Wang, Zhijie Qin, Zhemin Zhou, Jingwen Zhou   +4 more
doaj   +1 more source

Aniline is an inducer, and not a precursor, for indole derivatives in Rubrivivax benzoatilyticus JA2. [PDF]

PLoS ONE, 2014
Rubrivivax benzoatilyticus JA2 and other anoxygenic photosynthetic bacteria produce indole derivatives when exposed to aniline, a xenobiotic compound. Though this phenomenon has been reported previously, the role of aniline in the production of indoles ...
Mohammed Mujahid, Ch Sasikala, Ch V Ramana   +2 more
doaj   +1 more source

Deciphering the mechanism of anhydrobiosis in the entomopathogenic nematode Heterorhabditis indica through comparative transcriptomics.

PLoS ONE, 2022
The entomopathogenic nematode, Heterorhabditis indica, is a popular biocontrol agent of high commercial significance. It possesses tremendous genetic architecture to survive desiccation stress by undergoing anhydrobiosis to increase its lifespan-an ...
Manimaran Balakumaran, Parameshwaran Chidambaranathan, Jagannadham Prasanth Tej Kumar J P, Anil Sirohi, Pradeep Kumar Jain, Kishore Gaikwad, Yuvaraj Iyyappan, Atmakuri Ramakrishna Rao, Sarika Sahu, Anil Dahuja, Sharad Mohan   +10 more
doaj   +1 more source

Physiological Approach to the Use of the Natural Compound Quinate in the Control of Sensitive and Resistant Papaver rhoeas

Plants, 2020
Quinate (1,3,4,5-tetrahydroxycyclohexanecarboxylate) is a compound synthesized in plants through a side-branch of the shikimate biosynthesis pathway, which is accumulated after glyphosate and acetolactate synthase inhibiting herbicides (ALS-inhibitors ...
Ana Zabalza, Ainhoa Zulet-González, Maria Barco-Antoñanzas, Mikel V. Eceiza, Miriam Gil-Monreal, Mercedes Royuela   +5 more
doaj   +1 more source