SKPDB: a structural database of shikimate pathway enzymes [PDF]
BMC Bioinformatics, 2010 Background The functional and structural characterisation of enzymes that belong to microbial metabolic pathways is very important for structure-based drug design.
de Azevedo Walter F +7 more
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An Evolutionary Conservation and Druggability Analysis of Enzymes Belonging to the Bacterial Shikimate Pathway [PDF]
Antibiotics, 2022 Rok Frlan
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Valorization of xylose mother liquor into salidroside by engineered <i>Kluyveromyces marxianus</i>. [PDF]
Synth Syst BiotechnolLarge amounts of xylose mother liquor (XML) are produced as a byproduct of the xylose industry and are often treated as waste. Salidroside is a high-value glycoside with pharmaceutical and nutraceutical applications, but conventional extraction from ...
Wang L, Wang D, Hong J.
europepmc +2 more sources
Molecules, 2022 The shikimate pathway is a necessary pathway for the synthesis of aromatic compounds. The intermediate products of the shikimate pathway and its branching pathway have promising properties in many fields, especially in the pharmaceutical industry.
Sijia Wu +4 more
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The shikimate pathway: gateway to metabolic diversity. [PDF]
Nat Prod RepThe shikimate pathway is the metabolic process responsible for the biosynthesis of proteinogenic, aromatic amino acids as well as a bevy of specialized metabolites in bacteria, fungi, and plants.
Shende VV, Bauman KD, Moore BS.
europepmc +3 more sources
Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism. [PDF]
PLoS ONE, 2012 Shikimate kinase (SK), which catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP, is the enzyme in the fifth step of the shikimate pathway for biosynthesis of aromatic amino acids.
Wen-Chi Cheng +7 more
doaj +1 more source
Multiple Metabolic Engineering Strategies to Improve Shikimate Titer in Escherichia coli
Metabolites, 2023 Shikimate is a valuable chiral precursor for synthesizing oseltamivir (Tamiflu®) and other chemicals. High production of shikimate via microbial fermentation has attracted increasing attention to overcome the unstable and expensive supply of shikimate ...
Taidong Bo +6 more
doaj +1 more source
Molecules, 2021 Methicillin-resistant Staphylococcus aureus (MRSA) is an important threat as it causes serious hospital and community acquired infections with deathly outcomes oftentimes, therefore, development of new treatments against this bacterium is a priority ...
Lluvia Rios-Soto +7 more
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Pathway-based screening strategy for multitarget inhibitors of diverse proteins in metabolic pathways. [PDF]
PLoS Computational Biology, 2013 Many virtual screening methods have been developed for identifying single-target inhibitors based on the strategy of "one-disease, one-target, one-drug".
Kai-Cheng Hsu +4 more
doaj +1 more source
Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis. [PDF]
PLoS ONE, 2014 Due to the emergence of resistance toward current antibiotics, there is a pressing need to develop the next generation of antibiotics as therapeutics against infectious and opportunistic diseases of microbial origins.
Vivian Wing Ngar Cheung +7 more
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