The shikimate pathway: gateway to metabolic diversity. [PDF]
Nat Prod RepThe shikimate pathway is the metabolic process responsible for the biosynthesis of proteinogenic, aromatic amino acids as well as a bevy of specialized metabolites in bacteria, fungi, and plants.
Shende VV, Bauman KD, Moore BS.
europepmc +5 more sources
CRISPR-mediated multigene integration enables Shikimate pathway refactoring for enhanced 2-phenylethanol biosynthesis in Kluyveromyces marxianus [PDF]
Biotechnology for Biofuels, 2021 Background 2-phenylethanol (2-PE) is a rose-scented flavor and fragrance compound that is used in food, beverages, and personal care products. Compatibility with gasoline also makes it a potential biofuel or fuel additive.
Mengwan Li +6 more
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Shikimate and phenylalanine biosynthesis in the green lineage
Frontiers in Plant Science, 2013 The shikimate pathway provides carbon skeletons for the aromatic amino acids L-tryptophan, L-phenylalanine and L-tyrosine. It is a high flux bearing pathway and it has been estimated that greater than 30% of all fixed carbon is directed through this ...
Takayuki eTohge +3 more
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Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate [PDF]
Nature Communications, 2020 In lignocellulose biomass, microbes prefer consuming glucose over xylose, which affects target compound production. Here, the authors achieve simultaneous utilization of glucose and xylose for target chemical production and cell growth, respectively, and
Ryosuke Fujiwara +3 more
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Molecules, 2022 The shikimate pathway is a necessary pathway for the synthesis of aromatic compounds. The intermediate products of the shikimate pathway and its branching pathway have promising properties in many fields, especially in the pharmaceutical industry.
Sijia Wu +4 more
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Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism. [PDF]
PLoS ONE, 2012 Shikimate kinase (SK), which catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP, is the enzyme in the fifth step of the shikimate pathway for biosynthesis of aromatic amino acids.
Wen-Chi Cheng +7 more
doaj +1 more source
Multiple Metabolic Engineering Strategies to Improve Shikimate Titer in Escherichia coli
Metabolites, 2023 Shikimate is a valuable chiral precursor for synthesizing oseltamivir (Tamiflu®) and other chemicals. High production of shikimate via microbial fermentation has attracted increasing attention to overcome the unstable and expensive supply of shikimate ...
Taidong Bo +6 more
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Molecules, 2021 Methicillin-resistant Staphylococcus aureus (MRSA) is an important threat as it causes serious hospital and community acquired infections with deathly outcomes oftentimes, therefore, development of new treatments against this bacterium is a priority ...
Lluvia Rios-Soto +7 more
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Pathway-based screening strategy for multitarget inhibitors of diverse proteins in metabolic pathways. [PDF]
PLoS Computational Biology, 2013 Many virtual screening methods have been developed for identifying single-target inhibitors based on the strategy of "one-disease, one-target, one-drug".
Kai-Cheng Hsu +4 more
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Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis. [PDF]
PLoS ONE, 2014 Due to the emergence of resistance toward current antibiotics, there is a pressing need to develop the next generation of antibiotics as therapeutics against infectious and opportunistic diseases of microbial origins.
Vivian Wing Ngar Cheung +7 more
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