The Shikimate Pathway and Its Branches in Apicomplexan Parasites [PDF]
The Journal of Infectious Diseases, 2002 The shikimate pathway is essential for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Seven enzymes of the shikimate pathway catalyze sequential conversion of erythrose 4-phosphate and phosphoenol pyruvate to chorismate.
Roberts, C W +18 more
openaire +5 more sources
Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis. [PDF]
PLoS ONE, 2014 Due to the emergence of resistance toward current antibiotics, there is a pressing need to develop the next generation of antibiotics as therapeutics against infectious and opportunistic diseases of microbial origins.
Vivian Wing Ngar Cheung +7 more
doaj +2 more sources
Functional Analysis of 3-Dehydroquinate Dehydratase/Shikimate Dehydrogenases Involved in Shikimate Pathway in Camellia sinensis [PDF]
Frontiers in Plant Science, 2019 Polyphenols play an important role in the astringent taste of tea [Camellia sinensis (L.)] infusions; catechins in phenolic compounds are beneficial to health.
Keyi Huang +10 more
doaj +2 more sources
Shikimate and phenylalanine biosynthesis in the green lineage
Frontiers in Plant Science, 2013 The shikimate pathway provides carbon skeletons for the aromatic amino acids L-tryptophan, L-phenylalanine and L-tyrosine. It is a high flux bearing pathway and it has been estimated that greater than 30% of all fixed carbon is directed through this ...
Takayuki eTohge +3 more
doaj +2 more sources
Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate [PDF]
Nature Communications, 2020 In lignocellulose biomass, microbes prefer consuming glucose over xylose, which affects target compound production. Here, the authors achieve simultaneous utilization of glucose and xylose for target chemical production and cell growth, respectively, and
Ryosuke Fujiwara +3 more
doaj +2 more sources
Biosynthesis of the Antibiotic Echinosporin by a Novel Branch of the Shikimate Pathway
European Journal of Organic Chemistry, 2002 Echinosporin (1), a known antibiotic with a unique tricyclic acetal-lactone structure, is produced by Streptomyces erythraeus (strain Tu 4015), together with the novel 7-deoxyechinosporin (2) as minor compound, which was fully characterized. The biosynthesis of 1 was established by feeding experiments with 13C-labelled precursors.
Dubeler, A. +3 more
core +4 more sources
Molecules, 2022 The shikimate pathway is a necessary pathway for the synthesis of aromatic compounds. The intermediate products of the shikimate pathway and its branching pathway have promising properties in many fields, especially in the pharmaceutical industry.
Sijia Wu +4 more
doaj +1 more source
Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism. [PDF]
PLoS ONE, 2012 Shikimate kinase (SK), which catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP, is the enzyme in the fifth step of the shikimate pathway for biosynthesis of aromatic amino acids.
Wen-Chi Cheng +7 more
doaj +1 more source
Multiple Metabolic Engineering Strategies to Improve Shikimate Titer in Escherichia coli
Metabolites, 2023 Shikimate is a valuable chiral precursor for synthesizing oseltamivir (Tamiflu®) and other chemicals. High production of shikimate via microbial fermentation has attracted increasing attention to overcome the unstable and expensive supply of shikimate ...
Taidong Bo +6 more
doaj +1 more source
Molecules, 2021 Methicillin-resistant Staphylococcus aureus (MRSA) is an important threat as it causes serious hospital and community acquired infections with deathly outcomes oftentimes, therefore, development of new treatments against this bacterium is a priority ...
Lluvia Rios-Soto +7 more
doaj +1 more source