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The effect on shikimate production by deleting iolR and metabolic engineering in PTS deficient Corynebacterium glutamicum strain [PDF]
Frontiers in Bioengineering and BiotechnologyShikimate is a precursor to many high-value chemical derivatives. Several bacteria have been engineered to produce high titer of shikimate via non-phosphotransferase system (Non-PTS), but yet explores how the myo-inositol utilization transcription ...
Rui Wen Ou +8 more
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Shikimate and Phenylalanine Biosynthesis in the Green Lineage
Frontiers in Plant Science, 2013 The shikimate pathway provides carbon skeletons for the aromatic amino acids L-tryptophan, L-phenylalanine and L-tyrosine. It is a high flux bearing pathway and it has been estimated that greater than 30% of all fixed carbon is directed through this ...
Takayuki Tohge +2 more
exaly +3 more sources
Frontiers in Bioengineering and Biotechnology, 2018 The aromatic nature of shikimate pathway intermediates gives rise to a wealth of potential bio-replacements for commonly fossil fuel-derived aromatics, as well as naturally produced secondary metabolites.
Nils J H Averesch, Jens O Krömer
exaly +3 more sources
Engineering of Corynebacterium glutamicum for the synthesis of aromatic compounds [PDF]
Applied Microbiology and BiotechnologyA significant proportion of industrially important small molecules are aromatic, and the majority of these compounds are produced chemically, relying heavily on fossil resources.
Jan Marienhagen
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Multiple Metabolic Engineering Strategies to Improve Shikimate Titer in Escherichia coli
Metabolites, 2023 Shikimate is a valuable chiral precursor for synthesizing oseltamivir (Tamiflu®) and other chemicals. High production of shikimate via microbial fermentation has attracted increasing attention to overcome the unstable and expensive supply of shikimate ...
Taidong Bo +6 more
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Biophysica, 2021 The chemical step of Shikimate Kinase Helicobacter pylori, involving the transfer of a phosphoryl group, has been studied by using quantum mechanical and molecular mechanical (QM/MM) methods.
Pedro Ojeda-May
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Exploring the Dynamics of Shikimate Kinase through Molecular Mechanics
Biophysica, 2022 Shikimate kinase (SK) enzyme is a suitable target for antimicrobial drugs as it is present in pathogenic microorganisms and absent in mammals. A complete understanding of the functioning of this enzyme can unveil novel methods to inactivate it.
Pedro Ojeda-May
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Comparison of Sensitivity to Glyphosate of Euphorbia davidii Populations [PDF]
Planta Daninha, 2017 : Euphorbia davidii (Euphorbiaceae) is a summer annual weed present in the Province of Buenos Aires, Argentina. The aim of this study was to compare the sensitivity to glyphosate of different populations of Euphorbia davidii.
F.R. NÚÑEZ FRÉ +4 more
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Molecules, 2022 The shikimate pathway is a necessary pathway for the synthesis of aromatic compounds. The intermediate products of the shikimate pathway and its branching pathway have promising properties in many fields, especially in the pharmaceutical industry.
Sijia Wu +4 more
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Bioscience Journal, 2020 A sensitive and reliable process was established using high-performance liquid chromatography (HPLC) to distinguish conventional varieties of glyphosate-resistant genetically modified crops via shikimate detection in soybean (Glycine max L. Merril) seeds.
Edicléia Aparecida Bonini +4 more
doaj +3 more sources