Results 1 to 10 of about 985,996 (219)

Shikimate Kinase Plays Important Roles in Anthocyanin Synthesis in Petunia. [PDF]

Int J Mol Sci, 2022
In plants, the shikimate pathway is responsible for the production of aromatic amino acids L-tryptophan, L-phenylalanine, and L-tyrosine. L-Phenylalanine is the upstream substrate of flavonoid and anthocyanin synthesis.
Yuan J, Zhong S, Long Y, Guo J, Yu Y, Liu J.   +5 more
europepmc   +6 more sources

Gallic Acid: A Potent Metabolite Targeting Shikimate Kinase in Acinetobacter baumannii [PDF]

Metabolites
Background/Objectives: Acinetobacter baumannii is a highly multidrug-resistant pathogen resistant to almost all classes of antibiotics; new therapeutic strategies against this infectious agent are urgently needed.
Mansour S. Alturki, Abdulaziz H. Al Khzem, Mohamed S. Gomaa, Nada Tawfeeq, Marwah H. Alhamadah, Futun M. Alshehri, Raghad Alzahrani, Hanin Alghamdi, Thankhoe A. Rants’o, Khaled A. G. Ayil, Abdulaziz K. Al Mouslem, Mohammed Almaghrabi   +11 more
doaj   +5 more sources

Targeting Shikimate Kinase Pathway of Acinetobacter baumannii: A Structure-Based Computational Approach to Identify Antibacterial Compounds [PDF]

Journal of Tropical Medicine, 2023
Acinetobacter baumannii (A. baumannii) is an opportunistic bacterium that has developed multidrug resistance (MDR) to most of today’s antibiotics, posing a significant risk to human health.
Aparna Shil, Most. Afrin Akter, Arafin Sultana, Sajal Kumar Halder, Mahbubul Kabir Himel   +4 more
doaj   +3 more sources

Finding the First Potential Inhibitors of Shikimate Kinase from Methicillin Resistant Staphylococcus aureus through Computer-Assisted Drug Design [PDF]

Molecules, 2021
Methicillin-resistant Staphylococcus aureus (MRSA) is an important threat as it causes serious hospital and community acquired infections with deathly outcomes oftentimes, therefore, development of new treatments against this bacterium is a priority ...
Lluvia Rios-Soto, Alfredo Téllez-Valencia, Erick Sierra-Campos, Mónica Valdez-Solana, Jorge Cisneros-Martínez, Marcelo Gómez Palacio-Gastélum, Adriana Castillo-Villanueva, Claudia Avitia-Domínguez   +7 more
doaj   +3 more sources

Repurposing FDA-Approved Agents to Develop a Prototype Helicobacter pylori Shikimate Kinase (HPSK) Inhibitor: A Computational Approach Using Virtual Screening, MM-GBSA Calculations, MD Simulations, and DFT Analysis [PDF]

Pharmaceuticals
Background/Objectives: Helicobacter pylori infects approximately half of the global population, causing chronic gastritis, peptic ulcers, and gastric cancer, a leading cause of cancer mortality.
Abdulaziz H. Al Khzem, Tagyedeen H. Shoaib, Rua M. Mukhtar, Mansour S. Alturki, Mohamed S. Gomaa, Dania Hussein, Nada Tawfeeq, Mohsina Bano, Mohammad Sarafroz, Raghad Alzahrani, Hanin Alghamdi, Thankhoe A. Rants’o   +11 more
doaj   +3 more sources

Exploring the Dynamics of Holo-Shikimate Kinase through Molecular Mechanics

Biophysica, 2023
Understanding the connection between local and global dynamics can provide valuable insights into enzymatic function and may contribute to the development of novel strategies for enzyme modulation.
Pedro Ojeda-May
doaj   +4 more sources

Exploring the Dynamics of Shikimate Kinase through Molecular Mechanics

Biophysica, 2022
Shikimate kinase (SK) enzyme is a suitable target for antimicrobial drugs as it is present in pathogenic microorganisms and absent in mammals. A complete understanding of the functioning of this enzyme can unveil novel methods to inactivate it.
Pedro Ojeda-May
doaj   +4 more sources

Computational investigation of African natural products as Helicobacter pylori shikimate kinase inhibitors. [PDF]

PLoS ONE
Helicobacter pylori is one of the most prevalent bacteria, infecting more than 40% of the world's population. Rising antibiotic resistance has created an urgent need for the discovery of novel therapeutic agents.
Hari Ram Sharma Paudel
doaj   +4 more sources

Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments. [PDF]

J Comput Aided Mol Des, 2023
Tuberculosis (TB) is one of the main causes of death from a single pathological agent, Mycobacterium tuberculosis ( Mtb ). In addition, the emergence of drug-resistant TB strains has exacerbated even further the treatment outcome of TB patients.
Freitas de Freitas T, Roth CD, Abbadi BL, Hopf FSM, Perelló MA, de Matos Czeczot A, de Souza EV, Borsoi AF, Machado P, Bizarro CV, Basso LA, Timmers LFSM.   +11 more
europepmc   +2 more sources

Inhibition of Shikimate Kinase from Methicillin-Resistant Staphylococcus aureus by Benzimidazole Derivatives. Kinetic, Computational, Toxicological, and Biological Activity Studies. [PDF]

Int J Mol Sci
Antimicrobial resistance (AMR) is one of the biggest threats in modern times. It was estimated that in 2019, 1.27 million deaths occurred around the globe due to AMR.
Rios-Soto L, Hernández-Campos A, Tovar-Escobar D, Castillo R, Sierra-Campos E, Valdez-Solana M, Téllez-Valencia A, Avitia-Domínguez C.   +7 more
europepmc   +2 more sources