Exploring the Dynamics of Shikimate Kinase through Molecular Mechanics
Biophysica, 2022 Shikimate kinase (SK) enzyme is a suitable target for antimicrobial drugs as it is present in pathogenic microorganisms and absent in mammals. A complete understanding of the functioning of this enzyme can unveil novel methods to inactivate it.
Pedro Ojeda-May
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Gallic Acid: A Potent Metabolite Targeting Shikimate Kinase in Acinetobacter baumannii [PDF]
MetabolitesBackground/Objectives: Acinetobacter baumannii is a highly multidrug-resistant pathogen resistant to almost all classes of antibiotics; new therapeutic strategies against this infectious agent are urgently needed.
Mansour S. Alturki +11 more
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Exploring the Dynamics of Holo-Shikimate Kinase through Molecular Mechanics
Biophysica, 2023 Understanding the connection between local and global dynamics can provide valuable insights into enzymatic function and may contribute to the development of novel strategies for enzyme modulation.
Pedro Ojeda-May
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Evolutionary diversification of plant shikimate kinase gene duplicates. [PDF]
PLoS Genetics, 2008 Shikimate kinase (SK; EC 2.7.1.71) catalyzes the fifth reaction of the shikimate pathway, which directs carbon from the central metabolism pool to a broad range of secondary metabolites involved in plant development, growth, and stress responses. In this
Geoffrey Fucile +2 more
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Selective Mycobacterium tuberculosis Shikimate Kinase Inhibitors as Potential Antibacterials [PDF]
Perspectives in Medicinal Chemistry, 2015 Owing to the persistence of tuberculosis (TB) as well as the emergence of multidrug-resistant and extensively drug-resistant (XDR) forms of the disease, the development of new antitubercular drugs is crucial. Developing inhibitors of shikimate kinase (SK) in the shikimate pathway will provide a selective target for antitubercular agents.
Douglas Goodwin +2 more
exaly +5 more sources
Targeting Shikimate Kinase Pathway of Acinetobacter baumannii: A Structure-Based Computational Approach to Identify Antibacterial Compounds [PDF]
Journal of Tropical Medicine, 2023 Acinetobacter baumannii (A. baumannii) is an opportunistic bacterium that has developed multidrug resistance (MDR) to most of today’s antibiotics, posing a significant risk to human health.
Aparna Shil +4 more
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Finding the First Potential Inhibitors of Shikimate Kinase from Methicillin Resistant Staphylococcus aureus through Computer-Assisted Drug Design [PDF]
Molecules, 2021 Methicillin-resistant Staphylococcus aureus (MRSA) is an important threat as it causes serious hospital and community acquired infections with deathly outcomes oftentimes, therefore, development of new treatments against this bacterium is a priority ...
Lluvia Rios-Soto +7 more
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Shikimate Kinase Plays Important Roles in Anthocyanin Synthesis in Petunia. [PDF]
Int J Mol Sci, 2022 In plants, the shikimate pathway is responsible for the production of aromatic amino acids L-tryptophan, L-phenylalanine, and L-tyrosine. L-Phenylalanine is the upstream substrate of flavonoid and anthocyanin synthesis. Shikimate kinase (SK) catalyzes the phosphorylation of the C3 hydroxyl group of shikimate to produce 3-phosphate shikimate (S3P), the ...
Yuan J +5 more
europepmc +3 more sources
Computational investigation of African natural products as Helicobacter pylori shikimate kinase inhibitors [PDF]
PLoS ONEHelicobacter pylori is one of the most prevalent bacteria, infecting more than 40% of the world's population. Rising antibiotic resistance has created an urgent need for the discovery of novel therapeutic agents.
Hari Ram Sharma Paudel
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The mode of action of recombinant Mycobacterium tuberculosis shikimate kinase: kinetics and thermodynamics analyses. [PDF]
PLoS ONE, 2013 Tuberculosis remains as one of the main cause of mortality worldwide due to a single infectious agent, Mycobacterium tuberculosis. The aroK-encoded M.
Leonardo Astolfi Rosado +6 more
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