Evolutionary diversification of plant shikimate kinase gene duplicates. [PDF]
PLoS Genetics, 2008 Shikimate kinase (SK; EC 2.7.1.71) catalyzes the fifth reaction of the shikimate pathway, which directs carbon from the central metabolism pool to a broad range of secondary metabolites involved in plant development, growth, and stress responses. In this
Geoffrey Fucile +2 more
doaj +5 more sources
Slow-Binding Inhibition of Mycobacterium tuberculosis Shikimate Kinase by Manzamine Alkaloids. [PDF]
Biochemistry, 2018 Tuberculosis represents a significant public health crisis. There is an urgent need for novel molecular scaffolds against this pathogen. We screened a small library of marine-derived compounds against shikimate kinase from Mycobacterium tuberculosis ...
Simithy J +10 more
europepmc +6 more sources
Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone. [PDF]
Biochim Biophys Acta Proteins Proteom, 2018 Ilimaquinone (IQ), a marine sponge metabolite, has been considered as a potential therapeutic agent for various diseases due to its broad range of biological activities. We show that IQ irreversibly inactivates Mycobacterium tuberculosis shikimate kinase
Simithy J +6 more
europepmc +6 more sources
Shikimate Kinase-Like 1 Participates in an Ancient and Conserved Role Contributing to Chloroplast Biogenesis in Land Plants. [PDF]
Mol Biol EvolShikimate kinase-like 1 (SKL1) plays an essential role in chloroplast biogenesis in Arabidopsis thaliana whereby mutants present a pigment-defective phenotype.
Kanaris M +3 more
europepmc +2 more sources
Biophysica, 2021 The chemical step of Shikimate Kinase Helicobacter pylori, involving the transfer of a phosphoryl group, has been studied by using quantum mechanical and molecular mechanical (QM/MM) methods.
Pedro Ojeda-May
doaj +2 more sources
Molecular cloning and functional characterization of the shikimate kinase gene from Baphicacanthus cusia [PDF]
Frontiers in Plant ScienceBaphicacanthus cusia (Nee) Bremek, a perennial herbaceous plant with medicinal properties, has limited genomic insights regarding the genes involved in its indole alkaloid biosynthesis pathway.
Yuxiang Huang +10 more
doaj +2 more sources
The mode of action of recombinant Mycobacterium tuberculosis shikimate kinase: kinetics and thermodynamics analyses. [PDF]
PLoS ONE, 2013 Tuberculosis remains as one of the main cause of mortality worldwide due to a single infectious agent, Mycobacterium tuberculosis. The aroK-encoded M.
Leonardo Astolfi Rosado +6 more
doaj +2 more sources
Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism. [PDF]
PLoS ONE, 2012 Shikimate kinase (SK), which catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP, is the enzyme in the fifth step of the shikimate pathway for biosynthesis of aromatic amino acids.
Wen-Chi Cheng +7 more
doaj +2 more sources
Eugenol derivatives containing 1,2,3-triazole-chalcone hybrids for shikimate kinase inhibition
Journal of Saudi Chemical SocietyEugenol, a primary component of clove oil, is a compound of considerable interest in medicinal chemistry due to its demonstrated potential as an effective agent in various therapeutic applications.
Bayu Ardiansah +8 more
doaj +2 more sources
Isolation of alpha-linolenic acid from Sutherlandia frutescens and its inhibition of Mycobacterium tuberculosis' shikimate kinase enzyme. [PDF]
BMC Complement Altern Med, 2016 BackgroundSutherlandia frutescens (L) R.Br. is one of traditional herbal medicines that formed the basis of primary health care systems since the earliest days and is still widely used. Sutherlandia is prescribed for people with tuberculosis (TB), but is
Masoko P, Mabusa IH, Howard RL.
europepmc +2 more sources