Results 31 to 40 of about 985,996 (219)
Tazobactam selects for multidrug resistance [PDF]
npj Antimicrobials and ResistancePiperacillin-Tazobactam is a β-lactam/β-lactamase inhibitor combination that is amongst the most prescribed antimicrobials in hospital medicine.
Emma R. Holden +4 more
doaj +2 more sources
In silico approach towards the identification of potential inhibitors from Curcuma amada Roxb against H. pylori: ADMET screening and molecular docking studies [PDF]
BioImpacts, 2021 Introduction: The present study attempts to identify potential targets of H. pylori for novel inhibitors from therapeutic herb, mango ginger (Curcuma amada Roxb.).
G Divyashri +6 more
doaj +1 more source
Selective Mycobacterium tuberculosis Shikimate Kinase Inhibitors as Potential Antibacterials. [PDF]
Perspect Medicin Chem, 2015 Owing to the persistence of tuberculosis (TB) as well as the emergence of multidrug-resistant and extensively drug-resistant (XDR) forms of the disease, the development of new antitubercular drugs is crucial. Developing inhibitors of shikimate kinase (SK) in the shikimate pathway will provide a selective target for antitubercular agents.
Gordon S +3 more
europepmc +4 more sources
RETRACTED: Interaction of shikimic acid with shikimate kinase [PDF]
Biochemical and Biophysical Research Communications, 2004 Tuberculosis made a resurgence in the mid-1980s and now kills approximately 3 million people a year. The re-emergence of tuberculosis as a public health threat, the high susceptibility of HIV-infected persons and the proliferation of multi-drug-resistant strains have created a need to develop new drugs.
José Henrique Pereira +7 more
+9 more sources
Multiple Metabolic Engineering Strategies to Improve Shikimate Titer in Escherichia coli
Metabolites, 2023 Shikimate is a valuable chiral precursor for synthesizing oseltamivir (Tamiflu®) and other chemicals. High production of shikimate via microbial fermentation has attracted increasing attention to overcome the unstable and expensive supply of shikimate ...
Taidong Bo +6 more
doaj +1 more source
Structural Basis for Shikimate-Binding Specificity ofHelicobacter pyloriShikimate Kinase [PDF]
Journal of Bacteriology, 2005 ABSTRACTShikimate kinase (EC 2.7.1.71) catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP. As the fifth key step in the shikimate pathway for aromatic amino acid biosynthesis in bacteria, fungi, and plants, but not mammals, shikimate kinase represents an attractive target for the development of new ...
Wen-Chi, Cheng +2 more
openaire +2 more sources
Systemic suppression of the shoot metabolism upon rice root nematode infection [PDF]
, 2014 Hirschmanniella oryzae is the most common plant-parasitic nematode in flooded rice cultivation systems. These migratory animals penetrate the plant roots and feed on the root cells, creating large cavities, extensive root necrosis and rotting.
Bauters, Lander +4 more
core +9 more sources
Nature Communications, 2023 Cyanobacteria mutants with improved tolerance to combined high light and high temperature (HLHT) are rarely reported. Here, the authors use a hypermutation system for adaptive laboratory evolution and identify a mutant with improved HLHT tolerance by ...
Huili Sun +8 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 The production of aromatic compounds by microbial production is a promising and sustainable approach for producing biomolecules for various applications.
Naoki Sato +4 more
doaj +1 more source
A Conserved Structural Role for the Walker-A Lysine in P-Loop Containing Kinases
Frontiers in Molecular Biosciences, 2021 Bacterial tyrosine kinases (BY-kinases) and shikimate kinases (SKs) comprise two structurally divergent P-loop containing enzyme families that share similar catalytic site geometries, most notably with respect to their Walker-A, Walker-B, and DxD motifs.
Fatlum Hajredini +5 more
doaj +1 more source