Results 31 to 40 of about 5,044 (156)

Transcriptomic analysis reveals the transcription factors involved in regulating the expression of EPSPS gene, which confers glyphosate resistance of goosegrass (Eleusine indica)

Journal of Integrative Agriculture, 2021
Glyphosate inhibits the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) and overexpression of the EPSPS gene is one of the molecular mechanisms conferring glyphosate resistance in weeds.
Chun ZHANG, Chao-jie YU, Tai-jie ZHANG, Wen-lei GUO, Xing-shan TIAN   +4 more
doaj   +1 more source

Shikimate binding in Helicobacter pylori Shikimate Kinase

The FASEB Journal, 2006
Shikimate kinase (EC 2.7.1.71) catalyzes the specific phosphorylation of the 3‐hydroxyl group of shikimic acid in the presence of ATP. As the fifth key step in shikimate pathway for aromatic amino acid biosynthesis in bacteria, fungi, and plants, but not mammals, shikimate kinase represents an attractive target for the development ...
Wen‐Chi Cheng, Chiu‐Lien Hung, Yu‐Ning Chang, Wen‐Ching Wang   +3 more
openaire   +1 more source

Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase fromMycobacterium tuberculosis [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2006
Bacteria, fungi and plants can convert carbohydrate and phosphoenolpyruvate into chorismate, which is the precursor of various aromatic compounds. The seven enzymes of the shikimate pathway are responsible for this conversion. Shikimate kinase (SK) is the fifth enzyme in this pathway and converts shikimate to shikimate-3-phosphate.
Bertacine Dias, Marcio Vinicius, Faim, Livia Maria, Vasconcelos, Igor Bordin, de Oliveira, Jaim Simoes, Basso, Luiz Augusto, Santos, Diogenes Santiago, de Azevedo, Walter Filgueira   +6 more
openaire   +3 more sources

Transcriptome characterization of Larrea tridentata and identification of genes associated with phenylpropanoid metabolic pathways

PLoS ONE, 2022
Larrea tridentata (Sesse and Moc. ex DC.) Coville (family: Zygophyllaceae) is an aromatic evergreen shrub with resin-covered leaves, known to use in traditional medicine for diverse ailments.
Mohammad Ajmal Ali, Fahad Alhemaid, Mohammad Abul Farah, Meena Elangbam, Arun Bahadur Gurung, Khalid Mashay Al-Anazi, Joongku Lee   +6 more
doaj   +2 more sources

Combining metabolite doping and metabolic engineering to improve 2-phenylethanol production by engineered cyanobacteria

Frontiers in Bioengineering and Biotechnology, 2022
2-Phenylethanol (2-PE) is a rose-scented aromatic compound, with broad application in cosmetic, pharmaceutical, food and beverage industries. Many plants naturally synthesize 2-PE via Shikimate Pathway, but its extraction is expensive and low-yielding ...
Giulia Usai, Giulia Usai, Alessandro Cordara, Angela Re, Maria Francesca Polli, Maria Francesca Polli, Giuseppe Mannino, Cinzia Margherita Bertea, Debora Fino, Candido Fabrizio Pirri, Candido Fabrizio Pirri, Barbara Menin   +11 more
doaj   +1 more source

Study of the Phosphoryl‐Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy [PDF]

Chemistry – A European Journal, 2016
AbstractThe phosphoryl‐transfer mechanism of shikimate kinase from Mycobacterium tuberculosis and Helicobacter pylori, which is an attractive target for antibiotic drug discovery, has been studied by 1D 1H and 31P NMR spectroscopy. Metaphosphoric acid proved to be a good mimetic of the metaphosphate intermediate and facilitated the ready and rapid ...
Verónica Prado, Emilio Lence, Juan A. Vallejo, Alejandro Beceiro, Paul Thompson, Alastair R. Hawkins, Concepción González‐Bello   +6 more
openaire   +4 more sources

Tuberculosis shikimate kinase as a target for the development of new antimycobacterials

The FASEB Journal, 2021
Tuberculosis is a respiratory infection with over 10 million reported cases each year. This infection rate is responsible for over two million deaths annually, second only to HIV in fatalities among infectious diseases. Since 1960 tuberculosis rates have steadily declined worldwide as medical technology has advanced to produce more
Marcin Ogrodniczuk, René Fuanta
openaire   +1 more source

In Silico and In Vitro Anti-Helicobacter Pylori Effects of Combinations of Phytochemicals and Antibiotics

Molecules, 2019
Helicobacter pylori infection is a WHO class 1 carcinogenic factor of gastric adenocarcinoma. In the past decades, many studies have demonstrated the increasing trend of antibiotic resistance and pointed out the necessity of new effective treatment. This
Pedro Fong, Chon-Hou Hao, Chi-Cheng Io, Pou-Io Sin, Li-Rong Meng   +4 more
doaj   +1 more source

Novel kinase platform for the validation of the anti-tubercular activities of Pelargonium sidoides (Geraniaceae)

BMC Biotechnology, 2020
Background Pelargonium sidoides is an important traditional medicine in South Africa with a well-defined history of both traditional and documented use of an aqueous-ethanolic formulation of the roots of P.
V. Lukman, S. W. Odeyemi, R. L. Roth, L. Mbabala, N. Tshililo, N. M. Vlok, M. J. B. Dewar, C. P. Kenyon   +7 more
doaj   +1 more source

Integrative transcriptome analysis revealed the pathogenic molecular basis of Rhizoctonia solani AG-3 TB at three progressive stages of infection

Frontiers in Microbiology, 2022
Rhizoctonia solani has a broad host range and results in significant losses in agricultural production. Here, an integrated transcriptomic analysis was performed to reveal the critical genes responsible for the pathogenesis of R.
Xinchun Li, Mengnan An, Chuantao Xu, Chuantao Xu, Lianqiang Jiang, Fangfang Yan, Yang Yang, Chong Zhang, Yuanhua Wu   +8 more
doaj   +1 more source