Archaeal Shikimate Kinase, a New Member of the GHMP-Kinase Family [PDF]
Journal of Bacteriology, 2001 ABSTRACTShikimate kinase (EC2.7.1.71) is a committed enzyme in the seven-step biosynthesis of chorismate, a major precursor of aromatic amino acids and many other aromatic compounds. Genes for all enzymes of the chorismate pathway except shikimate kinase are found in archaeal genomes by sequence homology to their bacterial counterparts.
M, Daugherty +3 more
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Molecular phenotyping of the pal1 and pal2 mutants of Arabidopsis thaliana reveals far-reaching consequences on phenylpropanoid, amino acid, and carbohydrate metabolism [PDF]
, 2004 The first enzyme of the phenylpropanoid pathway, Phe ammonia-lyase (PAL), is encoded by four genes in Arabidopsis thaliana. Whereas PAL function is well established in various plants, an insight into the functional significance of individual gene family ...
Boerjan, Wout +13 more
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Pathway-based screening strategy for multitarget inhibitors of diverse proteins in metabolic pathways. [PDF]
PLoS Computational Biology, 2013 Many virtual screening methods have been developed for identifying single-target inhibitors based on the strategy of "one-disease, one-target, one-drug".
Kai-Cheng Hsu +4 more
doaj +1 more source
Pleiotropic and Epistatic Network-Based Discovery: Integrated Networks for Target Gene Discovery [PDF]
, 2018 Biological organisms are complex systems that are composed of functional networks of interacting molecules and macro-molecules. Complex phenotypes are the result of orchestrated, hierarchical, heterogeneous collections of expressed genomic variants ...
DiFazio, Stephen +14 more
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Journal of Integrative Agriculture, 2021 Glyphosate inhibits the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) and overexpression of the EPSPS gene is one of the molecular mechanisms conferring glyphosate resistance in weeds.
Chun ZHANG +4 more
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The acanthamoeba shikimate pathway has a unique molecular arrangement and is essential for aromatic amino acid biosynthesis [PDF]
, 2015 The shikimate pathway is the only known biosynthetic route for de novo synthesis of aromatic compounds. It is described as an ancient eukaryotic innovation that has been retained in a subset of eukaryotes, replaced in plants through the acquisition of ...
Campbell, Sara J. +5 more
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Shikimate Kinase Isoenzymes in Salmonella typhimurium
Journal of Biological Chemistry, 1968 Abstract A study was undertaken of the shikimate kinase activity of extracts of Salmonella typhimurium. Chromatography on diethylaminoethyl cellulose revealed consistently the presence of two widely separated peaks of activity, the faster moving enzyme being more unstable than the slower moving, major enzymic constituent.
H, Morell, D B, Sprinson
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Organellar carbon metabolism is co-ordinated with distinct developmental phases of secondary xylem [PDF]
, 2019 Subcellular compartmentation of plant biosynthetic pathways in the mitochondria and plastids requires coordinated regulation of nuclear encoded genes, and the role of these genes has been largely ignored by wood researchers. In this study, we constructed
Fierro Gutierrez, Ana Carolina Elisa +4 more
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Shikimate binding in Helicobacter pylori Shikimate Kinase
The FASEB Journal, 2006 Shikimate kinase (EC 2.7.1.71) catalyzes the specific phosphorylation of the 3‐hydroxyl group of shikimic acid in the presence of ATP. As the fifth key step in shikimate pathway for aromatic amino acid biosynthesis in bacteria, fungi, and plants, but not mammals, shikimate kinase represents an attractive target for the development ...
Wen‐Chi Cheng +3 more
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PLoS ONE, 2022 Larrea tridentata (Sesse and Moc. ex DC.) Coville (family: Zygophyllaceae) is an aromatic evergreen shrub with resin-covered leaves, known to use in traditional medicine for diverse ailments.
Mohammad Ajmal Ali +6 more
doaj +2 more sources