Results 21 to 30 of about 5,044 (156)

Tazobactam selects for multidrug resistance [PDF]

npj Antimicrobials and Resistance
Piperacillin-Tazobactam is a β-lactam/β-lactamase inhibitor combination that is amongst the most prescribed antimicrobials in hospital medicine.
Emma R. Holden, Muhammad Yasir, A. Keith Turner, Ian G. Charles, Mark A. Webber   +4 more
doaj   +2 more sources

RETRACTED: Interaction of shikimic acid with shikimate kinase [PDF]

Biochemical and Biophysical Research Communications, 2004
Tuberculosis made a resurgence in the mid-1980s and now kills approximately 3 million people a year. The re-emergence of tuberculosis as a public health threat, the high susceptibility of HIV-infected persons and the proliferation of multi-drug-resistant strains have created a need to develop new drugs.
José Henrique Pereira, Jaim Simões de Oliveira, Fernanda Canduri, Marcio Vinicius Bertacine Dias, Mário Sérgio Palma, Luiz Augusto Basso, Walter Filgueira de Azevedo, Diógenes Santiago Santos   +7 more
  +9 more sources

Multiple Metabolic Engineering Strategies to Improve Shikimate Titer in Escherichia coli

Metabolites, 2023
Shikimate is a valuable chiral precursor for synthesizing oseltamivir (Tamiflu®) and other chemicals. High production of shikimate via microbial fermentation has attracted increasing attention to overcome the unstable and expensive supply of shikimate ...
Taidong Bo, Chen Wu, Zeting Wang, Hao Jiang, Feiao Wang, Ning Chen, Yanjun Li   +6 more
doaj   +1 more source

Archaeal Shikimate Kinase, a New Member of the GHMP-Kinase Family [PDF]

Journal of Bacteriology, 2001
ABSTRACTShikimate kinase (EC2.7.1.71) is a committed enzyme in the seven-step biosynthesis of chorismate, a major precursor of aromatic amino acids and many other aromatic compounds. Genes for all enzymes of the chorismate pathway except shikimate kinase are found in archaeal genomes by sequence homology to their bacterial counterparts.
M, Daugherty, V, Vonstein, R, Overbeek, A, Osterman   +3 more
openaire   +2 more sources

Engineered hypermutation adapts cyanobacterial photosynthesis to combined high light and high temperature stress

Nature Communications, 2023
Cyanobacteria mutants with improved tolerance to combined high light and high temperature (HLHT) are rarely reported. Here, the authors use a hypermutation system for adaptive laboratory evolution and identify a mutant with improved HLHT tolerance by ...
Huili Sun, Guodong Luan, Yifan Ma, Wenjing Lou, Rongze Chen, Dandan Feng, Shanshan Zhang, Jiahui Sun, Xuefeng Lu   +8 more
doaj   +1 more source

Structural Basis for Shikimate-Binding Specificity ofHelicobacter pyloriShikimate Kinase [PDF]

Journal of Bacteriology, 2005
ABSTRACTShikimate kinase (EC 2.7.1.71) catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP. As the fifth key step in the shikimate pathway for aromatic amino acid biosynthesis in bacteria, fungi, and plants, but not mammals, shikimate kinase represents an attractive target for the development of new ...
Wen-Chi, Cheng, Yu-Ning, Chang, Wen-Ching, Wang   +2 more
openaire   +2 more sources

Metabolic Engineering of Shikimic Acid-Producing Corynebacterium glutamicum From Glucose and Cellobiose Retaining Its Phosphotransferase System Function and Pyruvate Kinase Activities

Frontiers in Bioengineering and Biotechnology, 2020
The production of aromatic compounds by microbial production is a promising and sustainable approach for producing biomolecules for various applications.
Naoki Sato, Mayumi Kishida, Mariko Nakano, Yuuki Hirata, Tsutomu Tanaka   +4 more
doaj   +1 more source

A Conserved Structural Role for the Walker-A Lysine in P-Loop Containing Kinases

Frontiers in Molecular Biosciences, 2021
Bacterial tyrosine kinases (BY-kinases) and shikimate kinases (SKs) comprise two structurally divergent P-loop containing enzyme families that share similar catalytic site geometries, most notably with respect to their Walker-A, Walker-B, and DxD motifs.
Fatlum Hajredini, Fatlum Hajredini, Ranajeet Ghose, Ranajeet Ghose, Ranajeet Ghose, Ranajeet Ghose   +5 more
doaj   +1 more source

Pathway-based screening strategy for multitarget inhibitors of diverse proteins in metabolic pathways. [PDF]

PLoS Computational Biology, 2013
Many virtual screening methods have been developed for identifying single-target inhibitors based on the strategy of "one-disease, one-target, one-drug".
Kai-Cheng Hsu, Wen-Chi Cheng, Yen-Fu Chen, Wen-Ching Wang, Jinn-Moon Yang   +4 more
doaj   +1 more source

Shikimate Kinase Isoenzymes in Salmonella typhimurium

Journal of Biological Chemistry, 1968
Abstract A study was undertaken of the shikimate kinase activity of extracts of Salmonella typhimurium. Chromatography on diethylaminoethyl cellulose revealed consistently the presence of two widely separated peaks of activity, the faster moving enzyme being more unstable than the slower moving, major enzymic constituent.
H, Morell, D B, Sprinson
openaire   +2 more sources