Results 21 to 30 of about 985,996 (219)

Molecular Hybridization of Naphthoquinones as Selective Inhibitors of Shikimate Kinase: A Promising Strategy Against Mycobacterium tuberculosis

Drugs and Drug Candidates
Background: Tuberculosis (TB) remains a critical global health concern, exacerbated by the emergence of multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis.
Beatriz C. T. de Oliveira, Dandara de Paula Candido, Acácio S. de Souza, Iva S. de Jesus, Fernando de C. da Silva, Leonardo Bruno P. F. Barreto, Samyra A. da Silveira, Yrneh Y. P. Palacios, Francisco das C. de Souza, Maria Cristina S. Lourenço, Carlos Mauricio R. Sant’Anna, Vitor F. Ferreira, Alcione S. de Carvalho   +12 more
doaj   +2 more sources

Comparative transcriptomic dynamics reveal molecular responses of susceptible and resistant Triticum aestivum genotypes to wheat stripe mosaic virus [PDF]

Scientific Reports
Soil-borne wheat mosaic disease (SBWMD), caused by wheat stripe mosaic virus (WhSMV), poses an emerging threat to wheat production in South America. In this study, we analyzed the transcriptomic responses of two Triticum aestivum genotypes exhibiting ...
Samara Campos Nascimento, Fernando Sartori Pereira, Vinicius Iura Abreu Silva, Vanucci Marcos Santi, Giselle Camargo Mendes, Douglas Lau, Antonio Nhani Junior, Poliana Fernanda Giachetto, Emilyn Emy Matsumura, Fabio Nascimento Silva   +9 more
doaj   +2 more sources

A multifaceted approach to identify non-specific enzyme inhibition:Application to Mycobacterium tuberculosis shikimate kinase [PDF]

Bioorganic & Medicinal Chemistry Letters, 2018
Single dose high-throughput screening (HTS) followed by dose-response evaluations is a common strategy for the identification of initial hits for further development.
Alturki, Mansour S., Calderón, Angela I., Fuanta, Ngolui Rene, Goodwin, Douglas C., Hobrath, Judith V., Jarrard, Madison A., Rants'o, Thankhoe A.   +6 more
core   +3 more sources

A century of vitamin E research: The innovative journey from basic biology to synthetic bio-manufacturing. [PDF]

J Integr Plant Biol
For a century, Vitamin E has been studied for its health benefits. This review traces its journey from basic biological discovery, and the recent identification of its link to chlorophyll degradation, to the modern era of sustainable microbial manufacturing, highlighting the innovative technologies that define its future production.
Zhang R, Ren Y, Zhao Y, Zheng H, Luo Y, Liu Y, Wang L, Zhang L.   +7 more
europepmc   +2 more sources

LC-MS-based Screening of East Indian Sandalwood Oil for Shikimate Kinase and Thioredoxin Reductase Inhibitory Activities

Natural Product Communications, 2017
M. tuberculosis shikimate kinase ( Mt SK) and P. falciparum thioredoxin reductase ( Pf TrxR) represent promising drug targets in tuberculosis and malaria therapy respectively.
Thankhoe A. Rants'o, Mansour Alturki, Corey Levenson, Angela I. Calderón   +3 more
doaj   +2 more sources

Interplay of rice vitamin E under osmotic and extreme temperature stresses revealed by a comparative transcriptomic approach [PDF]

BMC Plant Biology
Background Rice (Oryza sativa L.) is vulnerable to abiotic challenges. Understanding stress response mechanisms is therefore a priority for enhancing rice development. Tocopherol is a known antioxidant that helps plants adapt to various abiotic stresses.
Sara Kazemzadeh, Naser Farrokhi, Asadollah Ahmadikhah, Pär K. Ingvarsson   +3 more
doaj   +2 more sources

Combined transcriptomic and metabolomic analyses reveal the pharmacognostic mechanism of the metabolism of flavonoids in different parts of Polygonum capitatum [PDF]

The Plant Genome
The plant Polygonum capitatum (P. capitatum) contains a variety of flavonoids that are distributed differently among different parts. Nevertheless, differentially expressed genes (DEGs) associated with this heterogeneous distribution have not been ...
Jie Yang, Yu Zhang, Bu‐Fa Guo, Qi‐Lun Peng, Hong‐Yu Chen, Mao Ye, Wei Yi, Wei‐Jun Ding   +7 more
doaj   +2 more sources

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry [PDF]

ChemMedChem
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Vogel I, Verganista M, Candeias N.
europepmc   +2 more sources

Synthesis of rigidified shikimic acid derivatives by ring-closing metathesis to imprint inhibitor efficacy against shikimate kinase enzyme

Organic Chemistry Frontiers, 2019
The rigidification of the high-energy conformation of shikimic acid was used to enhance inhibitor efficacy against shikimate kinase enzyme, an attractive target for antibiotic drug discovery.
Marina Pernas, B. Blanco, E. Lence, P. Thompson, A. Hawkins, C. González‐Bello   +5 more
semanticscholar   +5 more sources

Putative type III effector SkP48 of Bradyrhizobium sp. DOA9 encoding a SUMO protease blocks nodulation in Vigna radiata [PDF]

Scientific Reports
Bradyrhizobium sp. DOA9 can nodulate a wide spectrum of legumes; however, unlike other bradyrhizobia, DOA9 carries a symbiotic plasmid harboring type III secretion system (T3SS) and several effector (T3E) genes, one of which encodes a putative type III ...
Pongdet Piromyou, Pongpan Songwattana, Jenjira Wongdee, Teerana Greetatorn, Pakpoom Boonchuen, Tarnee Phimphong, Hien P. Nguyen, Monchai Manassila, Waraporn Tanthanuch, Bussayarat Maikhunthod, Kamonluck Teamtisong, Panlada Tittabutr, Nantakorn Boonkerd, Eric Giraud, Neung Teaumroong   +14 more
doaj   +2 more sources