Results 61 to 70 of about 5,044 (156)

Metabolic engineering of Corynebacterium glutamicum for the production of anthranilate from glucose and xylose

Microbial Biotechnology
Anthranilate and its derivatives are important basic chemicals for the synthesis of polyurethanes as well as various dyes and food additives. Today, anthranilate is mainly chemically produced from petroleum‐derived xylene, but this shikimate pathway ...
Mario Mutz, Vincent Brüning, Christian Brüsseler, Moritz‐Fabian Müller, Stephan Noack, Jan Marienhagen   +5 more
doaj   +1 more source

Traversing the effects of ploidy changes in different Eragrostis curvula genotypes through high‐throughput RNA sequencing

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Polyploidization has played a key role in plant genome evolution. Eragrostis curvula (Schrad.) Ness, a perennial forage grass species of the Poaceae family, is an excellent model for investigating genome duplication due to its natural variation in ploidy levels.
D. F. Santoro, J. Carballo, M. C. Pasten, C. A. Gallo, E. Albertini, V. Echenique   +5 more
wiley   +1 more source

PPT1‐mediated plastidic phosphoenolpyruvate import enhances fatty acid biosynthesis in sugar‐rich tissues

New Phytologist, Volume 250, Issue 6, Page 3900-3913, June 2026.
Summary Metabolic engineering of vegetative tissues for lipid production holds transformative potential for sustainable biofuels, yet achieving sufficient yields remains challenging. Here, we present a strategy to enhance fatty acid synthesis by redirecting cytosolic phosphoenolpyruvate (PEP) into plastids through overexpression of the plastidial ...
Jiang Wang, Yi‐Hsuan Lin, Xueyi Xue, Gabriel Beuchat, Yaxin Li, Jiankun Li, Li‐Qing Chen   +6 more
wiley   +1 more source

Molecular Hybridization of Naphthoquinones as Selective Inhibitors of Shikimate Kinase: A Promising Strategy Against Mycobacterium tuberculosis

Drugs and Drug Candidates
Background: Tuberculosis (TB) remains a critical global health concern, exacerbated by the emergence of multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis.
Beatriz C. T. de Oliveira, Dandara de Paula Candido, Acácio S. de Souza, Iva S. de Jesus, Fernando de C. da Silva, Leonardo Bruno P. F. Barreto, Samyra A. da Silveira, Yrneh Y. P. Palacios, Francisco das C. de Souza, Maria Cristina S. Lourenço, Carlos Mauricio R. Sant’Anna, Vitor F. Ferreira, Alcione S. de Carvalho   +12 more
doaj   +1 more source

LC-MS-based Screening of East Indian Sandalwood Oil for Shikimate Kinase and Thioredoxin Reductase Inhibitory Activities

Natural Product Communications, 2017
M. tuberculosis shikimate kinase ( Mt SK) and P. falciparum thioredoxin reductase ( Pf TrxR) represent promising drug targets in tuberculosis and malaria therapy respectively.
Thankhoe A. Rants'o, Mansour Alturki, Corey Levenson, Angela I. Calderón   +3 more
doaj   +1 more source

Host‐Induced Silencing of Rhizoctonia Solani 5‐Enolpyruvylshikimate‐3‐Phosphate Synthase Impairs Its Virulence in Rice

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3573-3593, June 2026.
ABSTRACT Sheath blight disease of rice caused by the fungal pathogen R. solani AG1‐IA remains a big threat to rice production worldwide. A limited genetic variation in rice for tolerance to this pathogen and little success in understanding how it defeats host defence are major reasons behind it.
Vinod Kumar, Apoorva Prasad, Akshita Goel, Vijay Kumar Sharma, Jagjeet Singh Lore, Arun Kumar   +5 more
wiley   +1 more source

Targeting upstream and downstream arms of the bacterial shikimate metabolic network as an opportunity for antibacterial and antivirulence therapy

Discover Bacteria
The shikimate pathway is an essential metabolic route in bacteria that generates chorismate, a central intermediate linking primary metabolism to the biosynthesis of aromatic amino acids and diverse infection-relevant metabolites.
Reuben S. Maghembe
doaj   +1 more source

The BAHD Acyltransferase Gene Family: Evolutionary Dynamics, Biochemical Mechanisms, and Roles in Plant Stress Adaptation

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4139-4158, June 2026.
BAHD acyltransferases drive metabolic diversification in plants by coupling conserved catalytic scaffolds with regulatory flexibility, enabling stress adaptation and ecological specialisation. ABSTRACT BAHD acyltransferases constitute one of the most versatile enzyme superfamilies in plants, catalysing the acylation of alcohols, amines, polyamines, and
Muhammad Mubashar Zafar, Qiao Fei, Abdul Razzaq, Ayesha Siddiqua, Ayesha Naveed, M. Nasir Khan, Huma Saleem, Xuefei Jiang   +7 more
wiley   +1 more source

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source

Nidulantes of Aspergillus (Formerly Emericella): A Treasure Trove of Chemical Diversity and Biological Activities

Metabolites, 2020
The genus Emericella (Ascomycota) includes more than thirty species with worldwide distribution across many ecosystems. It is considered a rich source of diverse metabolites.
Najla Ali Alburae, Afrah E. Mohammed, Hajer Saeed Alorfi, Adnan Jaman Turki, Hani Zakaria Asfour, Walied Mohamed Alarif, Ahmed Abdel-Lateff   +6 more
doaj   +1 more source