Results 11 to 20 of about 14,898 (199)

Structural Basis for Shikimate-Binding Specificity ofHelicobacter pyloriShikimate Kinase [PDF]

Journal of Bacteriology, 2005
ABSTRACTShikimate kinase (EC 2.7.1.71) catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP. As the fifth key step in the shikimate pathway for aromatic amino acid biosynthesis in bacteria, fungi, and plants, but not mammals, shikimate kinase represents an attractive target for the development of new ...
Wen-Chi, Cheng, Yu-Ning, Chang, Wen-Ching, Wang   +2 more
openaire   +3 more sources

Novel technologies combined with traditional metabolic engineering strategies facilitate the construction of shikimate-producing Escherichia coli

Microbial Cell Factories, 2017
Shikimate is an important intermediate in the aromatic amino acid pathway, which can be used as a promising building block for the synthesis of biological compounds, such as neuraminidase inhibitor Oseltamivir (Tamiflu®).
Pengfei Gu, Xiangyu Fan, Quanfeng Liang, Qingsheng Qi, Qiang Li   +4 more
doaj   +2 more sources

Shikimate-Derived Meroterpenoids from the Ascidian-Derived Fungus Amphichorda felina SYSU-MS7908 and Their Anti-Glioma Activity

, 2023
Glioma is a clinically heterogeneous type of brain tumor with a poor prognosis. Current treatment approaches have limited effectiveness in treating glioma, highlighting the need for novel drugs.
Qilin Wu (9956363), Shuihao Chen (16324034), Senhua Chen (2544070), Heng Guo (215190), Lan Liu (88052), Xin Lu (24821), Minghua Jiang (6427763)   +6 more
core   +3 more sources

Increased Glyphosate-Induced Gene Expression in the Shikimate Pathway Is Abolished in the Presence of Aromatic Amino Acids and Mimicked by Shikimate

Frontiers in Plant Science, 2020
The herbicide glyphosate inhibits the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) in the aromatic amino acid (AAA) biosynthetic pathway, also known as the shikimate pathway.
Ainhoa Zulet-González, Maria Barco-Antoñanzas, Miriam Gil-Monreal, Mercedes Royuela, Ana Zabalza   +4 more
doaj   +1 more source

Antioxidant Enzyme and Cytochrome P450 Activities Are Involved in Horseweed (Conyza Sumatrensis) Resistance to Glyphosate

Stresses, 2022
The intensive global use of glyphosate has led to the evolution of glyphosate resistant (GR) weed species, including the economically damaging horseweed (Conyza sumatrensis). We evaluated the glyphosate resistance mechanisms of C. sumatrensis.
Gabrielly Cristina Kubis, Raizza Zorman Marques, Rafael Shinji Akiyama Kitamura, Arthur Arrobas Martins Barroso, Philippe Juneau, Marcelo Pedrosa Gomes   +5 more
doaj   +1 more source

First Case of Glyphosate Resistance in Bromus catharticus Vahl.: Examination of Endowing Resistance Mechanisms

Frontiers in Plant Science, 2021
Bromus catharticus Vahl. has been used as a valuable forage crop, but it has also been noted as a weed of winter crops and an invader in several countries. In Argentina, a putative glyphosate-resistant population of B.
Marcos Yanniccari, Marcos Yanniccari, José G. Vázquez-García, María E. Gómez-Lobato, María E. Gómez-Lobato, Antonia M. Rojano-Delgado, Pedro L. da C. A. Alves, Rafael De Prado   +7 more
doaj   +1 more source

Temperature influences glyphosate efficacy on glyphosate-resistant and -susceptible goosegrass (Eleusine indica)

Frontiers in Plant Science, 2023
Glyphosate has been widely used to control Eleusine indica and other weeds in South China for many years. Among the most troublesome weeds in South China, E. indica can remain alive all year round.
Wenlei Guo, Wenlei Guo, Chun Zhang, Chun Zhang, Siwei Wang, Siwei Wang, Taijie Zhang, Taijie Zhang, Xingshan Tian, Xingshan Tian   +9 more
doaj   +1 more source

CRISPR/Cas9‐mediated homology donor repair base editing confers glyphosate resistance to rice (Oryza sativa L.)

Frontiers in Plant Science, 2023
Globally, CRISPR-Cas9–based genome editing has ushered in a novel era of crop advancements. Weeds pose serious a threat to rice crop productivity.
Sonia Khan Sony, Tanushri Kaul, Khaled Fathy Abdel Motelb, Arulprakash Thangaraj, Jyotsna Bharti, Rashmi Kaul, Rachana Verma, Mamta Nehra   +7 more
doaj   +1 more source

In silico approach towards the identification of potential inhibitors from Curcuma amada Roxb against H. pylori: ADMET screening and molecular docking studies [PDF]

BioImpacts, 2021
Introduction: The present study attempts to identify potential targets of H. pylori for novel inhibitors from therapeutic herb, mango ginger (Curcuma amada Roxb.).
G Divyashri, T P Krishna Murthy, Subramaniam Sundareshan, Pavan Kamath, Manikanta Murahari, G R Saraswathy, Bindu Sadanandan   +6 more
doaj   +1 more source

Biocatalytic cascades towards iminosugar scaffolds reveals promiscuous activity of shikimate dehydrogenases

, 2022
Protecting group-free chemoenzymatic and biocatalytic cascade synthesis of iminosugars from sugar aminopolyols has been achieved using Galactose oxidase F2 and chemical or enzymatic imine reduction.
Lea, Gourbeyre, Sabine, Flitsch, Ashley, Mattey, Grayson, Ford, Christopher, Swanson   +4 more
core   +1 more source