Shikimate and phenylalanine biosynthesis in the green lineage [PDF]
The shikimate pathway provides carbon skeletons for the aromatic amino acids L-tryptophan, L-phenylalanine and L-tyrosine. It is a high flux bearing pathway and it has been estimated that greater than 30% of all fixed carbon is directed through this ...
Takayuki eTohge +3 more
doaj +6 more sources
Structural Basis for Shikimate-Binding Specificity ofHelicobacter pyloriShikimate Kinase [PDF]
ABSTRACTShikimate kinase (EC 2.7.1.71) catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP. As the fifth key step in the shikimate pathway for aromatic amino acid biosynthesis in bacteria, fungi, and plants, but not mammals, shikimate kinase represents an attractive target for the development of new ...
Wen-Chi, Cheng +2 more
openaire +4 more sources
Novel technologies combined with traditional metabolic engineering strategies facilitate the construction of shikimate-producing Escherichia coli [PDF]
Shikimate is an important intermediate in the aromatic amino acid pathway, which can be used as a promising building block for the synthesis of biological compounds, such as neuraminidase inhibitor Oseltamivir (Tamiflu®).
Pengfei Gu +4 more
doaj +2 more sources
Shikimate-Derived Meroterpenoids from the Ascidian-Derived Fungus Amphichorda felina SYSU-MS7908 and Their Anti-Glioma Activity [PDF]
Glioma is a clinically heterogeneous type of brain tumor with a poor prognosis. Current treatment approaches have limited effectiveness in treating glioma, highlighting the need for novel drugs.
Qilin Wu (9956363) +6 more
core +5 more sources
The metabolism of shikimate in the rat [PDF]
In the rat, shikimate was metabolized and excreted as hippurate, hexahydrohippurate, 3,4,5,6-tetrahydrohippurate, t-3,t-4-dihydroxycyclohexane-r-1-carboxylate and c-3,t-4-dihydroxycyclophexane-r-1-carboxylate, conjugates of catechol and CO2. The metabolism was entirely dependent on various initial microbial transformations in the gut, metabolite ...
D, Brewster, R S, Jones, D V, Parke
openaire +4 more sources
Biocatalytic cascades towards iminosugar scaffolds reveals promiscuous activity of shikimate dehydrogenases [PDF]
Protecting group-free chemoenzymatic and biocatalytic cascade synthesis of iminosugars from sugar aminopolyols has been achieved using Galactose oxidase F2 and chemical or enzymatic imine reduction.
Lea, Gourbeyre +4 more
core +1 more source
Virtual Screening, Molecular Docking and Dynamic Simulation of Shikimate Kinase from Mycobacterium Tuberculosis Using in Silico Approach [PDF]
Shikimate kinase (SK) is an enzyme that catalyzes the fifth steps in the shikimate pathway. The enzyme facilitate the transfer of phosphoryl from ATP to shikimate, to produce ADP and shikimate-3-phosphate from Mycobacterium tuberculosis (MTB).
Mustafa, Alhaji Isa
core +1 more source
The intensive global use of glyphosate has led to the evolution of glyphosate resistant (GR) weed species, including the economically damaging horseweed (Conyza sumatrensis). We evaluated the glyphosate resistance mechanisms of C. sumatrensis.
Gabrielly Cristina Kubis +5 more
doaj +1 more source
Bromus catharticus Vahl. has been used as a valuable forage crop, but it has also been noted as a weed of winter crops and an invader in several countries. In Argentina, a putative glyphosate-resistant population of B.
Marcos Yanniccari +7 more
doaj +1 more source
Glyphosate has been widely used to control Eleusine indica and other weeds in South China for many years. Among the most troublesome weeds in South China, E. indica can remain alive all year round.
Wenlei Guo +9 more
doaj +1 more source

