Results 41 to 50 of about 14,898 (199)

Shikimate binding in Helicobacter pylori Shikimate Kinase

The FASEB Journal, 2006
Shikimate kinase (EC 2.7.1.71) catalyzes the specific phosphorylation of the 3‐hydroxyl group of shikimic acid in the presence of ATP. As the fifth key step in shikimate pathway for aromatic amino acid biosynthesis in bacteria, fungi, and plants, but not mammals, shikimate kinase represents an attractive target for the development ...
Wen‐Chi Cheng, Chiu‐Lien Hung, Yu‐Ning Chang, Wen‐Ching Wang   +3 more
openaire   +1 more source

Evidence for the shikimate pathway in apicomplexan parasites

, 1998
Parasites of the phylum Apicomplexa cause substantial morbidity, mortality and economic losses, and new medicines to treat them are needed urgently.
Milhous, W K, Debopam Chakrabarti, Rima McLeod, Dennis E. Kyle, Tino Krell, Craig W. Roberts, David J. P. Ferguson, Ferguson, D J, Fiona Roberts, Roberts, C W, Tzipori, S, Jennifer J. Johnson, Wilbur K. Milhous, John R. Coggins, Saul Tzipori, Johnson, J J, Coggins, J R, Krell, T, Coombs, G H, Roberts, F, Chakrabarti, D, McLeod, R, Kyle, D E, Graham H. Coombs   +23 more
core   +2 more sources

Metabolic Engineering of the Shikimate Pathway for Production of Aromatics and Derived Compounds—Present and Future Strain Construction Strategies

Frontiers in Bioengineering and Biotechnology, 2018
The aromatic nature of shikimate pathway intermediates gives rise to a wealth of potential bio-replacements for commonly fossil fuel-derived aromatics, as well as naturally produced secondary metabolites.
Nils J. H. Averesch, Jens O. Krömer
doaj   +1 more source

SKPDB: a structural database of shikimate pathway enzymes

BMC Bioinformatics, 2010
Background The functional and structural characterisation of enzymes that belong to microbial metabolic pathways is very important for structure-based drug design.
de Azevedo Walter F, Machado José M, da Silveira Nelson JF, Bonalumi Carlos E, Marucci Evandro A, Zafalon Geraldo FD, Arcuri Helen A, Palma Mário S   +7 more
doaj   +1 more source

Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans

Life Science Alliance, 2022
Structural characterization of shikimate pathway multi-enzyme Aro1 from opportunistic fungal pathogen Candida albicans provides the first molecular image of all five domains.
Peter J Stogios, Sean D Liston, Cameron Semper, Bradley Quade, Karolina Michalska, Elena Evdokimova, Shane Ram, Zbyszek Otwinowski, Dominika Borek, Leah E Cowen, Alexei Savchenko   +10 more
doaj   +1 more source

Computational modelling provides insight into the effects of glyphosate on the shikimate pathway in the human gut microbiome

Current Research in Toxicology, 2020
The herbicide active ingredient glyphosate can affect the growth of microorganisms, which rely on the shikimate pathway for aromatic amino acid biosynthesis.
Robin Mesnage, Michael N. Antoniou
doaj   +1 more source

The three-dimensional structure of shikimate kinase

, 1998
The three-dimensional structure of shikimate kinase from Erwinia chrysanthemi has been determined by multiple isomorphous replacement. Two models are presented: a high resolution 1.9 Å model and a 2.6 Å model which contains bound Mg-ADP. The enzyme is an
Coggins, John R., Krell, Tino, Lapthorn, Adrian J.   +2 more
core   +1 more source

In situ monitoring of the Shikimate pathway: A combinatorial approach of Raman reverse stable isotope probing and hyperspectral imaging.

Our research is focused on evaluating the potentials of Raman reverse stable isotope probing for sensing and visualizing the Shikimate pathway activity in prokaryotic and eukaryotic model systems in a cost-effective and non-destructive manner at ...
Aryan, Gupta, SURYA PRATAP, SINGH, Jiro, Karlo   +2 more
core   +1 more source

Creation of a Shikimate Pathway Variant

, 2016
The competition between the Escherichia coli carbohydrate phosphotransferase system and 3-deoxy-d-arabino-heptulosonate 7-phosphate (DAHP) synthase for phosphoenolpyruvate limits the concentration and yield of natural products microbially synthesized via
K. M. Draths (2715604), J. W. Frost (2685595), Ningqing Ran (2715601)   +2 more
core   +1 more source

The formation of homogentisate in the biosynthesis of tocopherol and plastoquinone in spinach chloroplasts [PDF]

, 1982
Homogentisate is the precursor in the biosynthesis of -tocopherol and plastoquinone-9 in chloroplasts. It is formed of 4-hydroxyphenylpyruvate of the shikimate pathway by the 4-hydroxyphenylpyruvate dioxygenase.
Soll, Jürgen, Jürgen Soll, Schultz, Gernot, Fiedler, Erich, Erich Fiedler, Gernot Schultz   +5 more
core   +1 more source