Results 31 to 40 of about 12,231 (188)

Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis. [PDF]

PLoS ONE, 2014
Due to the emergence of resistance toward current antibiotics, there is a pressing need to develop the next generation of antibiotics as therapeutics against infectious and opportunistic diseases of microbial origins.
Vivian Wing Ngar Cheung, Bo Xue, Maria Hernandez-Valladares, Maybelle Kho Go, Alvin Tung, Adeleke H Aguda, Robert C Robinson, Wen Shan Yew   +7 more
doaj   +1 more source

Genomic Analysis of Microbulbifer sp. Strain A4B-17 and the Characterization of Its Metabolic Pathways for 4-Hydroxybenzoic Acid Synthesis

Frontiers in Microbiology, 2018
The marine bacterium Microbulbifer sp. A4B-17 produces secondary metabolites such as 4-hydroxybenzoic acid (4HBA) and esters of 4HBA (parabens). 4HBA is a useful material in the synthesis of the liquid crystal.
Jun Tian, Li Zhu, Wenjun Wang, Liping Zhang, Zhi Li, Qingyu Zhao, Ke Xing, Zhaozhong Feng, Xue Peng   +8 more
doaj   +1 more source

Xylose and shikimate transporters facilitates microbial consortium as a chassis for benzylisoquinoline alkaloid production

Nature Communications, 2023
Plant-sourced aromatic amino acid (AAA) derivatives are a vast group of compounds with broad applications. Here, we present the development of a yeast consortium for efficient production of (S)-norcoclaurine, the key precursor for benzylisoquinoline ...
Meirong Gao, Yuxin Zhao, Zhanyi Yao, Qianhe Su, Payton Van Beek, Zengyi Shao   +5 more
doaj   +1 more source

Novel technologies combined with traditional metabolic engineering strategies facilitate the construction of shikimate-producing Escherichia coli

Microbial Cell Factories, 2017
Shikimate is an important intermediate in the aromatic amino acid pathway, which can be used as a promising building block for the synthesis of biological compounds, such as neuraminidase inhibitor Oseltamivir (Tamiflu®).
Pengfei Gu, Xiangyu Fan, Quanfeng Liang, Qingsheng Qi, Qiang Li   +4 more
doaj   +1 more source

The mode of action of recombinant Mycobacterium tuberculosis shikimate kinase: kinetics and thermodynamics analyses. [PDF]

PLoS ONE, 2013
Tuberculosis remains as one of the main cause of mortality worldwide due to a single infectious agent, Mycobacterium tuberculosis. The aroK-encoded M.
Leonardo Astolfi Rosado, Igor Bordin Vasconcelos, Mário Sérgio Palma, Vincent Frappier, Rafael Josef Najmanovich, Diógenes Santiago Santos, Luiz Augusto Basso   +6 more
doaj   +1 more source

Accumulation of Polyphenolics and Differential Expression of Genes Related to Shikimate Pathway during Fruit Development and Maturation of Chinese Olive (Canarium album)

Agronomy, 2023
Phenolics in the Chinese olive (Canarium album (Lour.) Raeusch) fruit significantly affect its flavor and quality. The shikimate pathway is a bridge connecting primary metabolism and secondary metabolism through which fixed carbon can be transformed into
Jingrong Cai, Naiyu Wang, Junyue Zhao, Yan Zhao, Rong Xu, Fanghao Fu, Tengfei Pan, Yuan Yu, Zhixiong Guo, Wenqin She   +9 more
doaj   +1 more source

Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease

Journal of Periodontology, EarlyView.
Abstract Background Emerging evidence supports a bidirectional link between periodontitis and inflammatory bowel disease (IBD). To investigate this relationship, experimental models commonly use dextran sodium sulfate (DSS) to induce colitis. However, DSS is presumed to selectively affect the colon, and its potential off‐target effects on the oral ...
Himanshi Tanwar, Jeba Mercy Gnanasekaran, Niyant Ganesh, Cindy Zhou, Amy Plotkin, Giacomo Baima, Massimo Costalonga, Fenfen Zhou, Hanping Feng, Priyam Jani, Jean‐Pierre Raufman, Vivek Thumbigere‐Math   +11 more
wiley   +1 more source

Targeted modulation of the shikimate pathway enhances bacterial wilt resistance through NbMEE32 suppression in tobacco

Industrial Crops and Products
The shikimate pathway serves as a central metabolic route for the biosynthesis of aromatic amino acids and diverse secondary metabolites involved in plant growth and defense.
Dong Cheng, Dan Zhou, Jiahui Wu, Bingsen Wang, Yuhan Li, Botao Song, Huilan Chen, Juan Du   +7 more
doaj   +1 more source

Pathway-based screening strategy for multitarget inhibitors of diverse proteins in metabolic pathways. [PDF]

PLoS Computational Biology, 2013
Many virtual screening methods have been developed for identifying single-target inhibitors based on the strategy of "one-disease, one-target, one-drug".
Kai-Cheng Hsu, Wen-Chi Cheng, Yen-Fu Chen, Wen-Ching Wang, Jinn-Moon Yang   +4 more
doaj   +1 more source

Target‐site and non‐target‐site mechanisms confer multiple herbicide resistance in waterhemp (Amaranthus tuberculatus) accessions from Wisconsin

Pest Management Science, EarlyView.
The A101 accession is the first confirmed case of hydroxyphenyl pyruvate dioxygenase resistance in Amaranthus tuberculatus in Wisconsin, and the first report of P450s associated with atrazine resistance in A. tuberculatus globally. Abstract BACKGROUND A preliminary screening identified a multiple herbicide‐resistant waterhemp, Amaranthus tuberculatus ...
Felipe A. Faleco, Isabel S. Werle, Alexander J. Lopez, Damilola A. Raiyemo, Patrick J. Tranel, Jed B. Colquhoun, Mark J. Renz, David E. Stoltenberg, Rodrigo Werle   +8 more
wiley   +1 more source