Results 121 to 130 of about 165,368 (343)

Cell Behaviors during Closure of the Choroid Fissure in the Developing Eye

Frontiers in Cellular Neuroscience, 2018
Coloboma is a defect in the morphogenesis of the eye that is a consequence of failure of choroid fissure fusion. It is among the most common congenital defects in humans and can significantly impact vision.
G. Gestri, Naiara Bazin-Lopez, Clarissa Scholes, Stephen W. Wilson   +3 more
semanticscholar   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Age and myopia associated optical coherence tomography of retina and choroid in pediatric eyes

Indian Journal of Ophthalmology, 2018
Purpose: To evaluate the association between retinal and choroidal thickness and volume along with choroidal vessel volume in children using optical coherence tomography (OCT) images.
Jyoti Matalia, Neha Sutheekshna Anegondi, Leio Veeboy, Abhijit Sinha Roy   +3 more
doaj   +1 more source

Laser in Clinical Ophthalmology: Possible Applications, Limitations, and Hazards [PDF]

, 1965
The present status of laser application in clinical ophthalmology is discussed. The differences between conventional light coagulator characteristics and those of presently available ruby lasers for clinical use are compared.
Geeraets, Walter J.
core   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

Embryonic cerebrospinal fluid pressure in fetal mice in utero: External factors pressurize the intraventricular space

Developmental Dynamics, EarlyView.
Abstract Background Previous experiments inducing leakage of embryonic cerebrospinal fluid (CSF) suggest the necessity of intraventricular CSF pressure (PCSF) for brain morphogenesis. Nevertheless, how embryonic PCSF occurs is unclear, especially in utero. Results Using a Landis water manometer, we measured PCSF in fetal mice isolated from the amniotic
Koichiro Tsujikawa, Reina Muramatsu, Takaki Miyata   +2 more
wiley   +1 more source

Febrile status epilepticus and epileptogenesis: The FEBSTAT study

Epilepsia Open, EarlyView.
Abstract The multicenter FEBSTAT study (Consequences of Prolonged Febrile Seizures in Childhood: https://grantome.com/grant/NIH/R37‐NS043209‐12; PI S. Shinnar) examined the outcome of febrile status epilepticus (FSE) in over 200 prospectively enrolled infants, with many followed for 10 years after FSE.
Darrell V. Lewis, Douglas R. Nordli Jr., Douglas R. Nordli III, Shlomo Shinnar, Stephen Chan, Jacqueline A. Bello, L. Matthew Frank, James Voyvodic, William Gallentine, Syndi Seinfeld, Yoshimi Sogawa, Erica Weiss, David Masur, Yuan Xu, Solomon L. Moshé   +14 more
wiley   +1 more source

OTX2 Signals from the Choroid Plexus to Regulate Adult Neurogenesis

eNeuro, 2018
Proliferation and migration during adult neurogenesis are regulated by a microenvironment of signaling molecules originating from local vasculature, from CSF produced by the choroid plexus, and from local supporting cells including astrocytes.
A. Planques, Vanessa Oliveira Moreira, Chantal Dubreuil, A. Prochiantz, Ariel A. Di Nardo   +4 more
semanticscholar   +1 more source

Differential glymphatic dysfunction and memory correlation in temporal lobe epilepsy subtypes

Epilepsia Open, EarlyView.
Abstract Objective This study aims to evaluate the glymphatic system (GS) in different temporal lobe epilepsy (TLE) subtypes using diffusion tensor imaging analysis along the perivascular space (DTI‐ALPS) and to explore its correlation with clinical factors and memory performance.
Ruotong Chen, Hong Li, Pu Miao, Hongyi Ye, Xiao Chen, Yuyu Yang, Jinqi Zhou, Yihe Chen, Yi Ge, Chenmin He, Xiaotong Shao, Zijian Wang, Yuting Gong, Cong Chen, Shan Wang, Lingli Hu, Lingqi Ye, Yao Ding, Shuang Wang, Linglin Yang   +19 more
wiley   +1 more source

Effect of vascular endothelial growth factor inhibitors on choroid in patients with macular choroid neovascular membrane and degenerative myopia . Preliminary report

Oftalʹmologiâ, 2014
Purpose: to assess the effect of vascular endothelial growth factor inhibitors on choroid in patients with myopic macular choroid neovascular membrane.Methods: 12 eyes (12 patients) aged 19-47 years with myopia and macular choroid neovascular membrane ...
V. A. Solomin, D. A. Magaramov, G. F. Kachalina   +2 more
doaj   +1 more source