Results 1 to 10 of about 150,893 (261)
The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
Cell, 2023 SUMMARY The choroid plexus (ChP) is the blood-cerebrospinal fluid (CSF) barrier and the primary source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks drug treatments due to obscure pathobiology.
Emre Kızıltuğ +2 more
exaly +2 more sources
Choroid plexus epithelium and its role in neurological diseases
Frontiers in Molecular Neuroscience, 2022 Choroid plexus epithelial cells can secrete cerebrospinal fluid into the ventricles, serving as the major structural basis of the selective barrier between the neurological system and blood in the brain.
Ruizhen Liu +21 more
doaj +2 more sources
A cellular and spatial map of the choroid plexus across brain ventricles and ages
Cell, 2021 SUMMARY The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain.
Rebecca H Herbst +2 more
exaly +2 more sources
Non-invasive measurement of choroid plexus apparent blood flow with arterial spin labeling
Fluids and Barriers of the CNS, 2020 Background The choroid plexus is a major contributor to the generation of cerebrospinal fluid (CSF) and the maintenance of its electrolyte and metabolite balance.
Li Zhao +4 more
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The choroid plexus and its role in the pathogenesis of neurological infections
Fluids and Barriers of the CNS, 2022 The choroid plexus is situated at an anatomically and functionally important interface within the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the periphery from the central nervous system.
Derick Thompson +2 more
doaj +2 more sources
Cell Stem Cell, 2020 Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be fatal. However, neurological symptoms have also been observed in some patients.
Laura Pellegrini +2 more
exaly +2 more sources
The choroid plexus synergizes with immune cells during neuroinflammation
CellSUMMARY The choroid plexus (ChP) is a vital brain barrier and source of cerebrospinal fluid (CSF). Here, we use longitudinal two-photon imaging in awake mice and single-cell transcriptomics to elucidate mechanisms of ChP regulation of brain inflammation.
Huixin Xu +16 more
exaly +2 more sources
Choroid Plexus Pathophysiology
Annual Review of Pathology: Mechanisms of DiseaseThis review examines the roles of the choroid plexus (ChP) in central nervous system (CNS) pathology, emphasizing its involvement in disease mechanisms and therapeutic potential. Structural changes in the human ChP have been reported across various diseases in case reports and descriptive work, but studies have yet to pin down the physiological ...
Courtney, Ya’el +2 more
openaire +3 more sources
Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation
Developmental Cell, 2020 The choroid plexus (ChP) regulates brain development by secreting instructive cues and providing a protective brain barrier. Here, we show that polyI:C-mediated maternal immune activation leads to an inflammatory response in the developing embryonic ...
Frederick B Shipley +2 more
exaly +2 more sources
Evidence for reduced choroid plexus volume in the aged brain [PDF]
Fluids and Barriers of the CNSBackground The choroid plexus plays an important role in brain homeostasis, including the active secretion of cerebrospinal fluid. Its function and structure have been reported to be affected by normal ageing. However, existing measures of choroid plexus
R. Youh +7 more
doaj +2 more sources