Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate [PDF]
Nature Communications, 2022 The cerebrospinal fluid-secreting choroid plexus needs a balanced level of canonical Wnt signaling. Here the authors show that if this signaling is over-activated, the choroid plexus loses its properties and function, and transforms to a neuronal ...
Arpan Parichha +13 more
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Choroid plexus epithelium and its role in neurological diseases
Frontiers in Molecular Neuroscience, 2022 Choroid plexus epithelial cells can secrete cerebrospinal fluid into the ventricles, serving as the major structural basis of the selective barrier between the neurological system and blood in the brain.
Ruizhen Liu +21 more
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The choroid plexus and its role in the pathogenesis of neurological infections
Fluids and Barriers of the CNS, 2022 The choroid plexus is situated at an anatomically and functionally important interface within the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the periphery from the central nervous system.
Derick Thompson +2 more
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Non-invasive measurement of choroid plexus apparent blood flow with arterial spin labeling
Fluids and Barriers of the CNS, 2020 Background The choroid plexus is a major contributor to the generation of cerebrospinal fluid (CSF) and the maintenance of its electrolyte and metabolite balance.
Li Zhao +4 more
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Frontiers in Neuroanatomy, 2022 The choroid plexus has recently been identified as a possible migration route for peripheral immune cells into the central nervous system. For future investigation of this route, profound knowledge of the morphology of the murine choroid plexus is a ...
Theresa Greiner +8 more
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Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited
Fluids and Barriers of the CNS, 2022 Cerebrospinal fluid (CSF) envelops the brain and fills the central ventricles. This fluid is continuously replenished by net fluid extraction from the vasculature by the secretory action of the choroid plexus epithelium residing in each of the four ...
N. MacAulay, R. Keep, T. Zeuthen
semanticscholar +1 more source
Axial multi-layer perceptron architecture for automatic segmentation of choroid plexus in multiple sclerosis [PDF]
Proc. SPIE Medical Imaging 2022, 2021 Choroid plexuses (CP) are structures of the ventricles of the brain which produce most of the cerebrospinal fluid (CSF). Several postmortem and in vivo studies have pointed towards their role in the inflammatory process in multiple sclerosis (MS). Automatic segmentation of CP from MRI thus has high value for studying their characteristics in large ...
arxiv +1 more source
Choroid plexus volume in multiple sclerosis predicts expansion of chronic lesions and brain atrophy
Annals of Clinical and Translational Neurology, 2022 Recent studies suggested that the expansion of long‐standing multiple sclerosis (MS) lesions and an enlargement of choroid plexus may be linked to chronic inflammation and microglial activation.
S. Klistorner +5 more
semanticscholar +1 more source
Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder
Neurology, 2022 The choroid plexus has been shown to play a crucial role in CNS inflammation. Previous studies found larger choroid plexus in multiple sclerosis (MS) compared with healthy controls.
J. Müller +34 more
semanticscholar +1 more source
Targeting choroid plexus epithelium as a novel therapeutic strategy for hydrocephalus
Journal of Neuroinflammation, 2022 The choroid plexus is a tissue located in the lateral ventricles of the brain and is composed mainly of choroid plexus epithelium cells. The main function is currently thought to be the secretion of cerebrospinal fluid and the regulation of its pH, and ...
Yijian Yang +7 more
doaj +1 more source