Results 1 to 10 of about 155,416 (337)

Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate [PDF]

Nature Communications, 2022
The cerebrospinal fluid-secreting choroid plexus needs a balanced level of canonical Wnt signaling. Here the authors show that if this signaling is over-activated, the choroid plexus loses its properties and function, and transforms to a neuronal ...
Arpan Parichha, Varun Suresh, Mallika Chatterjee, Aditya Kshirsagar, Lihi Ben-Reuven, Tsviya Olender, M. Mark Taketo, Velena Radosevic, Mihaela Bobic-Rasonja, Sara Trnski, Michael J. Holtzman, Nataša Jovanov-Milosevic, Orly Reiner, Shubha Tole   +13 more
doaj   +4 more sources

JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor. [PDF]

PLoS Pathogens, 2020
The human polyomavirus, JCPyV, is the causative agent of progressive multifocal leukoencephalopathy (PML) in immunosuppressed and immunomodulated patients.
Bethany A O'Hara, Jenna Morris-Love, Gretchen V Gee, Sheila A Haley, Walter J Atwood   +4 more
doaj   +4 more sources

Choroid plexus epithelium and its role in neurological diseases

Frontiers in Molecular Neuroscience, 2022
Choroid plexus epithelial cells can secrete cerebrospinal fluid into the ventricles, serving as the major structural basis of the selective barrier between the neurological system and blood in the brain.
Ruizhen Liu, Ruizhen Liu, Ruizhen Liu, Zhiping Zhang, Zhiping Zhang, Zhiping Zhang, Yibing Chen, Yibing Chen, Yibing Chen, Junbo Liao, Junbo Liao, Junbo Liao, Yuchang Wang, Yuchang Wang, Yuchang Wang, Jingping Liu, Jingping Liu, Jingping Liu, Zhixiong Lin, Gelei Xiao, Gelei Xiao, Gelei Xiao   +21 more
doaj   +2 more sources

Annexin A5 prevents amyloid-β-induced toxicity in choroid plexus: implication for Alzheimer’s disease [PDF]

Scientific Reports, 2020
In Alzheimer's disease (AD) amyloid-beta (A beta) deposits may cause impairments in choroid plexus, a specialised brain structure which forms the blood-cerebrospinal fluid (CSF) barrier.
Abramov, Andrey Y., Alcolea, Daniel, Antequera, Desiree, Bartolome, Fernando, Carro, Eva, de la Cueva, Macarena, Ferrer, Isidro, Fortea, Juan, Hardy, John, Krzyzanowska, Agnieszka, Lleó, Alberto, Pascual, Consuelo, Rabano, Alberto, Spuch, Carlos, Universitat Autònoma de Barcelona, Villarejo-Galende, Alberto   +15 more
core   +5 more sources

The choroid plexus and its role in the pathogenesis of neurological infections

Fluids and Barriers of the CNS, 2022
The choroid plexus is situated at an anatomically and functionally important interface within the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the periphery from the central nervous system.
Derick Thompson, Catherine A. Brissette, John A. Watt   +2 more
doaj   +2 more sources

Hypertensive nonobstructive hydrocephalus as main magnetic resonance imaging feature in a dog with disseminated choroid plexus carcinomatosis [PDF]

Journal of Veterinary Internal Medicine, 2023
Obstructive or nonobstructive hypertensive hydrocephalus is reported in choroid plexus tumors. Choroid plexus tumors typically present as T2‐weighted hyperintense intraventricular masses with occasional cerebrospinal fluid‐drop metastasis.
Lea Carisch, Lorenzo Golini, Lea Schurna, Chiara Bergamino, Katrin M. Beckmann, Monika Hilbe, Thanaporn Asawapattanakul, Wolfgang Baumgärtner, Christina Puff, Adriano Wang‐Leandro   +9 more
doaj   +2 more sources

Non-invasive measurement of choroid plexus apparent blood flow with arterial spin labeling

Fluids and Barriers of the CNS, 2020
Background The choroid plexus is a major contributor to the generation of cerebrospinal fluid (CSF) and the maintenance of its electrolyte and metabolite balance.
Li Zhao, Manuel Taso, Weiying Dai, Daniel Z. Press, David C. Alsop   +4 more
doaj   +2 more sources

Paclitaxel triggers molecular and cellular changes in the choroid plexus [PDF]

Frontiers in Pain Research
Paclitaxel is a widely used chemotherapeutic agent for treating various solid tumors. However, resulting neuropathic pain, often a lifelong side effect of paclitaxel, can limit dosing and compromise optimal treatment.
Alemeh Zamani, Parisa EmamiAref, Lucie Kubíčková, Klaudia Hašanová, Ondřej Šandor, Petr Dubový, Marek Joukal   +6 more
doaj   +2 more sources

Klotho controls the brain-immune system interface in the choroid plexus. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood.
Ho, Kaitlyn, Kim, Daniel, Larsson, Tobias E, Mucke, Lennart, Stein, Liana R, Yu, Gui-Qiu, Zhan, Lihong, Zhu, Lei   +7 more
core   +2 more sources

Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles [PDF]

EMBO Molecular Medicine, 2016
Here, we identified release of extracellular vesicles (EVs) by the choroid plexus epithelium (CPE) as a new mechanism of blood-brain communication. Systemic inflammation induced an increase in EVs and associated pro-inflammatory miRNAs, including miR ...
An Hendrix, Beutler B, Claude Libert, Delphine Demeestere, Elien Van Wonterghem, Koen Raemdonck, Kris Gevaert, Liu L, Marjana Brkic, Riet De Rycke, Roosmarijn E Vandenbroucke, Seehusen DA, Sriram Balusu, Stephan Stremersch, Valerie Vanhooren   +14 more
core   +3 more sources