Results 81 to 90 of about 121,184 (301)
Nature Communications, 2018 LbCpf1, derived from Lachnospiraceae bacterium ND2006, is a CRISPR RNA-guided endonuclease and holds promise for therapeutic applications. Here we show that LbCpf1 can be used for therapeutic gene editing in a mouse model of age-related macular ...
T. Koo +8 more
semanticscholar +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose Pregnancy induces significant changes in the body, including increased peripheral and choroidal blood perfusion and an increased systemic corticosteroid level. Here, we systematically reviewed the evidence on pregnancy as a risk factor for developing central serous chorioretinopathy (CSC) and conducted a meta‐analysis to obtain a ...
Nathalie Skovgaard Eriksen +15 more
wiley +1 more source
Matrix Metalloproteinases and Glaucoma Treatment. [PDF]
, 2020 Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade extracellular matrix (ECM) components such as collagen and have important roles in multiple biological processes, including development and tissue remodeling, both in ...
Dibas, Mohammed +3 more
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Natural product inhibitors of ocular angiogenesis [PDF]
, 2014 Natural products are characterized by high chemical diversity and biochemical specificity; therefore, they are appealing as lead compounds for drug discovery.
Basavarajappa, Halesha D. +2 more
core +2 more sources
Drug Delivery, 2018 Bevacizumab is an anti-vascular endothelial growth factor drug that can be used to treat choroidal neovascularization (CNV). Bevacizumab-loaded multivesicular liposomes (Bev-MVLs) have been designed and developed to increase the intravitreal retention ...
Hongjie Mu +11 more
semanticscholar +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose The retinal pigment epithelium (RPE) is critical in the pathophysiology of retinal diseases, such as age‐related macular degeneration. Adaptive optics transscleral flood illumination (AO‐TFI) offers rapid, detailed morphometric characterization of the RPE layer.
Leila Sara Eppenberger +8 more
wiley +1 more source
Choroidal neovascularization secondary to Best’s vitelliform macular dystrophy in two siblings of a Malay family [PDF]
, 2014 Best’s vitelliform macular dystrophy complicated with choroidal neovascularization is rare in children. We report three children from a Malay family of five siblings with Best’s vitelliform macular dystrophy, in which two of them subsequently developed ...
Embong, Zunaina +4 more
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Axial length, myopia progression, and myopic maculopathy in Stickler syndrome
Acta Ophthalmologica, EarlyView.Abstract Purpose We lack knowledge on the potentially progressive nature of and the prevalence of complications to myopia as a characteristic trait of Stickler syndrome. Methods This cross‐sectional study combines ophthalmic examination and medical record data on Danish patients with genetically confirmed Stickler syndrome type 1 (COL2A1) and type 2 ...
Kirstine B. Boysen +4 more
wiley +1 more source
Choroidal neovascularization after intraocular foreign body
Clinical Ophthalmology, 2014 Ester Fernández-López, Mari Carmen Desco-Esteban, Adriana Fandiño-López, Mikhail Hernández-Díaz, Amparo NaveaDepartment of Vitreoretinal Diseases, FISABIO Oftalmología Médica, Valencia ...
Fernández-López E +4 more
doaj
Inflammatory and angiogenic protein detection in the human vitreous : cytometric bead assay [PDF]
, 2011 Introduction. To evaluate clinical feasibility and reproducibility of cytometric bead assay (CBA) in nondiluted vitreous samples of patients with age-related macular degeneration (ARMD), diabetic macular edema (DME), and central retinal vein occlusion ...
Koch, Frank H. +2 more
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