Nature Communications, 2020 WABS patient derived cells display loss of sister chromatid cohesion. Here the authors by analyzing WABS patient derived cells, reveal a role of the DDX11 helicase in resolving G-Quadruplex structures to support sister chromatid cohesion.
Janne J M Van Schie +2 more
exaly +2 more sources
Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function. [PDF]
PLoS Genetics, 2018 The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription. The Nipped-B-Mau2 protein complex
Ziva Misulovin +3 more
doaj +1 more source
Guiding functions of the C-terminal domain of topoisomerase IIα advance mitotic chromosome assembly
Nature Communications, 2021 Topoisomerase IIα (topo IIα) is critical for mitotic chromatid assembly. Here the authors report a refinement of the mitotic chromatid reconstitution assay and provide novel insights into the C-terminal domain (CTD) of topo IIα.
Keishi Shintomi, Tatsuya Hirano
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Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei. [PDF]
PLoS Genetics, 2016 Following DNA replication, sister chromatids must stay connected for the remainder of the cell cycle in order to ensure accurate segregation in the subsequent cell division.
T Niroshini Senaratne +3 more
doaj +1 more source
Replication factor C complexes play unique pro- and anti-establishment roles in sister chromatid cohesion. [PDF]
PLoS ONE, 2010 Recent studies have lead to a rapid expansion of sister chromatid cohesion pathways. Of particular interest is the growth in classifications of anti-establishment factors-now including those that are cohesin-associated (Rad61/WAPL and Pds5) or DNA ...
Marie E Maradeo, Robert V Skibbens
doaj +1 more source
Genome Biology, 2022 Background Cohesin is a chromosome-associated SMC–kleisin complex that mediates sister chromatid cohesion, recombination, and most chromosomal processes during mitosis and meiosis.
Eui-Hwan Choi +7 more
doaj +1 more source
Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion. [PDF]
PLoS Genetics, 2018 Establishment of sister chromatid cohesion is coupled to DNA replication, but the underlying molecular mechanisms are incompletely understood. DDX11 (also named ChlR1) is a super-family 2 Fe-S cluster-containing DNA helicase implicated in Warsaw breakage
Giuseppe Cortone +8 more
doaj +1 more source
Biology, 2021 Cohesion between replicated chromosomes is essential for chromatin dynamics and equal segregation of duplicated genetic material. In the G1 phase, the ring-shaped cohesin complex is loaded onto duplex DNA, enriching at replication start sites, or ...
Sarah S. Henrikus, Alessandro Costa
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The chromosomal association of the Smc5/6 complex depends on cohesion and predicts the level of sister chromatid entanglement. [PDF]
PLoS Genetics, 2014 The cohesin complex, which is essential for sister chromatid cohesion and chromosome segregation, also inhibits resolution of sister chromatid intertwinings (SCIs) by the topoisomerase Top2. The cohesin-related Smc5/6 complex (Smc5/6) instead accumulates
Kristian Jeppsson +11 more
doaj +1 more source
Sequential loading of cohesin subunits during the first meiotic prophase of grasshoppers. [PDF]
PLoS Genetics, 2007 The cohesin complexes play a key role in chromosome segregation during both mitosis and meiosis. They establish sister chromatid cohesion between duplicating DNA molecules during S-phase, but they also have an important role during postreplicative double-
Ana M Valdeolmillos +10 more
doaj +1 more source