Results 61 to 70 of about 971,786 (390)

Internal modifications in the CENP-A nucleosome modulate centromeric dynamics

Epigenetics & Chromatin, 2017
Background Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 variant CENP-A, few modifications have
Minh Bui, Mary Pitman, Arthur Nuccio, Serene Roque, Paul Gregory Donlin-Asp, Aleksandra Nita-Lazar, Garegin A. Papoian, Yamini Dalal   +7 more
doaj   +1 more source

EpiAlign: an alignment-based bioinformatic tool for comparing chromatin state sequences. [PDF]

, 2019
The availability of genome-wide epigenomic datasets enables in-depth studies of epigenetic modifications and their relationships with chromatin structures and gene expression.
Ge, Xinzhou, Kwon, Soo Bin, Li, Jingyi Jessica, Li, Wei Vivian, Xie, Lingjue, Zhang, Haowen   +5 more
core   +2 more sources

Slx5/Slx8-dependent ubiquitin hotspots on chromatin contribute to stress tolerance [PDF]

, 2019
Chromatin is a highly regulated environment, and protein association with chromatin is often controlled by post-translational modifications and the corresponding enzymatic machinery.
Habermann, B., Hoepfler, M., Jentsch, S., Kern, M., Pfander, B., Prytuliak, R., Straub, T.   +6 more
core   +3 more sources

Meeting Summary of the 6th European Workshop on Plant Chromatin 2019 in Cologne, Germany [PDF]

, 2020
In June 2019, more than a hundred plant researchers met in Cologne, Germany, for the 6th European Workshop on Plant Chromatin (EWPC). This conference brought together a highly dynamic community of researchers with the common aim to understand how ...
Engelhorn, Julia, Farrona, Sara, Kalyanikrishna, Moreno-Romero, Jordi, Probst, Aline V., Trindade, Inês   +5 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

The chromatin accessibility landscape of primary human cancers

Science, 2018
Cancer chromatin accessibility landscape The Cancer Genome Atlas (TCGA) provides a high-quality resource of molecular data on a large variety of human cancers. Corces et al.
M. Corces, Jeffrey M. Granja, Shadi Shams, Bryan H. Louie, J. Seoane, Wanding Zhou, T. Silva, C. Groeneveld, Christopher K. Wong, S. Cho, Ansuman T. Satpathy, Maxwell R Mumbach, K. Hoadley, A. G. Robertson, Nathan C. Sheffield, Ina Felau, Mauro A. A. Castro, B. Berman, L. Staudt, J. Zenklusen, P. Laird, C. Curtis, W. Greenleaf, Howard Y. Chang   +23 more
semanticscholar   +1 more source

Chromatin Computation

PLoS ONE, 2012
In living cells, DNA is packaged along with protein and RNA into chromatin. Chemical modifications to nucleotides and histone proteins are added, removed and recognized by multi-functional molecular complexes. Here I define a new computational model, in which chromatin modifications are information units that can be written onto a one-dimensional ...
openaire   +5 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

In vitro Histone H3 Cleavage Assay for Yeast and Chicken Liver H3 Protease

Bio-Protocol, 2017
Histone proteins are subjected to a wide array of reversible and irreversible post-translational modifications (PTMs) (Bannister and Kouzarides, 2011; Azad and Tomar, 2014).
Sakshi Chauhan, Gajendra Azad, Raghuvir Tomar   +2 more
doaj   +1 more source

Roles of replication fork-interacting and Chk1-activating domains from claspin in a DNA replication checkpoint response [PDF]

, 2005
Claspin is essential for the ATR-dependent activation of Chk1 in Xenopus egg extracts containing incompletely replicated DNA. Claspin associates with replication forks upon origin unwinding.
Dunphy, William G., Gold, Daniel A., Lee, Joon, Shevchenko, Andrej, Shevchenko, Anna   +4 more
core   +2 more sources