Results 61 to 70 of about 834,176 (358)

The dynamics of replication licensing in live Caenorhabditis elegans embryos [PDF]

, 2012
Accurate DNA replication requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replication origins. In this paper, we provide the first comprehensive view of replication licensing in vivo, using video microscopy of ...
Anton Gartner, Ashley Craig, Baldinger, Blow, Blow, Brauchle, Brenner, Cheeseman, Chen, Clarey, Clarey, DePamphilis, Drury, Edgar, Encalada, Evrin, Galy, Gambus, Gillespie, Hadwiger, Harvey, Ilves, J. Julian Blow, Kamath, Kim, Kisielewska, Korzelius, Kuipers, Li, Li, Li, Liu, Matthieu Querenet, McNairn, McNally, Moyer, Oehlmann, Praitis, Prokhorova, Quinn, Randell, Remi Sonneville, Remus, Rothbauer, Rowles, Shelton, Siddiqui, Speck, Sönnichsen, Tada, Timmons, Waga, Wallenfang, Wohlschlegel, Yanagi, Yang, Zhong   +56 more
core   +4 more sources

Chromatin and Splicing

, 2014
In the past several years, the relationship between chromatin structure and mRNA processing has been the source of significant investigation across diverse disciplines. Central to these efforts was an unanticipated nonrandom distribution of chromatin marks across transcribed regions of protein-coding genes.
Nazmul, Haque, Shalini, Oberdoerffer
openaire   +3 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Structural basis of cyclobutane pyrimidine dimer recognition by UV-DDB in the nucleosome

Nature Communications
In mammalian global genomic nucleotide excision repair, UV-DDB plays a central role in recognizing DNA lesions, such as 6-4 photoproducts and cyclobutane pyrimidine dimers, within chromatin.
Syota Matsumoto, Yoshimasa Takizawa, Mitsuo Ogasawara, Kana Hashimoto, Lumi Negishi, Wenjie Xu, Haruna Tachibana, Junpei Yamamoto, Shigenori Iwai, Kaoru Sugasawa, Hitoshi Kurumizaka   +10 more
doaj   +1 more source

A role for chromatin remodellers in replication of damaged DNA [PDF]

, 2011
In eukaryotic cells, replication past damaged sites in DNA is regulated by the ubiquitination of proliferating cell nuclear antigen (PCNA). Little is known about how this process is affected by chromatin structure.
Chambers, Anna L, Downs, Jessica A, Lehmann, Alan R, Niimi, Atsuko   +3 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Toward a molecular understanding of yeast silent chromatin : roles for H4K16 acetylation and the Sir3 C-terminus [PDF]

, 2012
Discrete regions of the eukaryotic genome assume a heritable chromatin structure that is refractory to gene expression. In budding yeast, silent chromatin is characterized by the loading of the Silent Information Regulatory (Sir) proteins (Sir2, Sir3 and
Oppikofer, Mariano
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Changes in the nuclear distribution of DNA polymerase alpha and PCNA/cyclin during the progress of the cell cycle, in a cell-free extract of Xenopus eggs [PDF]

, 1989
The nuclear distribution of DNA polymerase alpha and PCNA/cyclin in embryonic nuclei has been investigated, in a cell-free extract of Xenopus eggs that recapitulates a basic cell-cycle in vitro, by indirect immunofluorescence microscopy.
Hutchison, C, Kill, IR
core  

Lysosome-mediated processing of chromatin in senescence [PDF]

, 2013
Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism, and a likely contributor to tissue aging. Cellular senescence involves extensive cellular remodeling, including of chromatin structure. Autophagy and lysosomes are
Adams, Adams-Cioaba, Andre Ivanov, Barnhill, Barradas, Bodnar, Braig, Bridger, Butin-Israeli, Cao, Chen, Chen, Coffinier, Collado, Cosme-Blanco, Dang, David M. Nelson, De Cecco, De Cecco, De Vos, Demidenko, Di Micco, Duncan, Feldser, Feser, Fraga, Freund, Funayama, Glatz, Goldman, Graeme Hewitt, Gray-Schopfer, Gray-Schopfer, Greer, Hayflick, Hong Wu, Houben, Howard, Hunt, Ichijima, Iglesias-Bartolome, Imai, Indrani Manoharan, Ishidoh, Jeff Pawlikowski, Joao F. Passos, John van Tuyn, Kanfi, Kang, Kennedy, Klionsky, Kreiling, Krizhanovsky, Krtolica, Kuilman, Lamark, Laszlo, Lee, Maures, McManus, Michaloglou, Michishita, Narita, Narita, Narita, Omholt, O’Sullivan, Pankiv, Parisha P. Shah, Passos, Peleg, Peter D. Adams, Pollock, Pospelova, Ruhoy, Sagiv, Santos-Rosa, Scaffidi, Serrano, Shelley L. Berger, Shimi, Shimi, Siebold, Smolle, Smolle, Soutoglou, Suram, Taranjit Singh Rai, Tran, Vargas, Vergnes, Viktor I. Korolchuk, Villeponteau, Wang, Wood, Xue, Yang, Young, Zhang, Zhang, Ziegler-Birling   +100 more
core   +2 more sources