Results 131 to 140 of about 2,271,159 (299)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

mSphere of Influence: Trypanosoma cruzi genome in 3D action

mSphere
Luisa Berná works in the field of comparative and evolutionary genomics in unicellular eukaryotes. In this mSphere of Influence article, she reflects on how advances in three-dimensional genome organization have reshaped our understanding of parasite ...
Luisa Berná
doaj   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Visualization of the architecture of flexible chromatin and the binding of chromatin regulators

Abstract Chromatin organization plays a central role in regulating genome accessibility and gene expression in eukaryotic cells. However, the inherent flexibility and structural heterogeneity of chromatin pose significant challenges for its structure determination. Here, we use a Nuc-back strategy with cryo-electron tomography (cryo-ET)
Haonan Zhang, Yan Li, Chengcai Pan, Fu Bo, Cong Yu, Weiwei Niu, Huimin Yang, Kai Song, Ping Zhu   +8 more
openaire   +1 more source

Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages

Epigenetics & Chromatin
The precise spatiotemporal expression of the hematopoietic ETS transcription factor PU.1, a key determinant of hematopoietic cell fates, is tightly regulated at the chromatin level.
Kevin Qiu, Duc C. Vu, Leran Wang, Nicholas N. Nguyen, Anna K. Bookstaver, Katia Sol-Church, Hui Li, Thang N. Dinh, Adam N. Goldfarb, Daniel G. Tenen, Bon Q. Trinh   +10 more
doaj   +1 more source

Advances in DNA methylation and its role in cytoplasmic male sterility in higher plants

Journal of Integrative Agriculture
The impact of epigenetic modifications like DNA methylation on plant phenotypes has expanded the possibilities for crop development. DNA methylation plays a part in the regulation of both the chromatin structure and gene expression, and the enzyme ...
Atiqur Rahman, Md. Hasan Sofiur Rahman, Md. Shakil Uddin, Naima Sultana, Shirin Akhter, Ujjal Kumar Nath, Shamsun Nahar Begum, Md. Mazadul Islam, Afroz Naznin, Md. Nurul Amin, Sharif Ahmed, Akbar Hossain   +11 more
doaj   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

Unveiling the Epigenetic Role of Arabidopsis PWO1: Linking Linear Chromatin Features to 3D Genome Architecture

UNVEILING THE EPIGENETIC ROLE OF ARABIDOPSIS PWO1: LINKING LINEAR CHROMATIN FEATURES TO 3D GENOME ARCHITECTURE Unveiling the Epigenetic Role of Arabidopsis PWO1: Linking Linear Chromatin Features to 3D Genome Architecture / Ghosh, Biswajit (Rights ...
Ghosh, Biswajit
core  

Isolation of a vicilin gene from pea (pisum sativum l.), and nuclease sensitivity of seed storage protein genes in pea chromatin [PDF]

, 1986
A library of pea genomic DNA in the bacteriophage vector EMBL3 was screened by hybridisation to cDNAs encoding vicilin, a major storage protein of pea (Pisum sativum L.) seeds.
Sawyer, Rosalind Mary
core  

The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity

, 2014
Histone variant H3.3 is deposited in chromatin at active sites, telomeres, and pericentric heterochromatin by distinct chaperones, but the mechanisms of regulation and coordination of chaperone-mediated H3.3 loading remain largely unknown.
Küntziger, Thomas, Delbarre, Erwan, Wong, Lee H., Ivanauskiene, Kristina, McGhie, James D., Collas, Philippe   +5 more
core   +1 more source