Results 211 to 220 of about 77,159 (253)
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Tracing chromatin architecture
Nature Reviews Genetics, 2020A study in Cell presents a new approach that increases resolution and throughput compared with existing imaging methods and provides insights into the relationship between transcription and the 3D genome.
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PIQ-ing into chromatin architecture
Nature Biotechnology, 2014Decrypting the logic of gene regulation is aided by a breakthrough method for analyzing chromatin-accessibility data.
Sebastian, Rieck, Christopher, Wright
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Reprogramming of Meiotic Chromatin Architecture during Spermatogenesis [PDF]
Molecular Cell, 2019 Chromatin organization undergoes drastic reconfiguration during gametogenesis. However, the molecular reprogramming of three-dimensional chromatin structure in this process remains poorly understood for mammals, including primates. Here, we examined three-dimensional chromatin architecture during spermatogenesis in rhesus monkey using low-input Hi-C ...
Yao Wang, Zhenhai Du, Wei Si
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The architecture and function of the chromatin replication machinery
Current Opinion in Structural Biology, 2017Genomic DNA in eukaryotic cells is packaged into nucleosome arrays. During replication, nucleosomes need to be dismantled ahead of the advancing replication fork and reassembled on duplicated DNA. The architecture and function of the core replisome machinery is now beginning to be elucidated, with recent insights shaping our view on DNA replication ...
Thomas Cr, Miller, Alessandro, Costa
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Current Opinion in Structural Biology, 2006
A complete understanding of the structure-function relationships of chromatin requires extending primarily one dimensional information, obtained from molecular genetic techniques and based on the underlying linear DNA sequence, to the three dimensional conformation.
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A complete understanding of the structure-function relationships of chromatin requires extending primarily one dimensional information, obtained from molecular genetic techniques and based on the underlying linear DNA sequence, to the three dimensional conformation.
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Chromatin and nuclear architecture in the nervous system
Trends in Neurosciences, 2008Neurons are arguably the most varied cell type both morphologically and functionally. Their fate during differentiation and development and the activity of mature neurons are significantly determined and regulated by chromatin. The nucleus is compartmentalized and the arrangement of these compartments, termed the nuclear architecture, distinguishes one
Takumi, Takizawa, Eran, Meshorer
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Chromatin architecture is a flexible foundation for gene expression
Nature Genetics, 2021The structure of chromatin is associated with its function, but precisely how is unclear. New data show that the higher-order architecture of the genome is similar among cell types with widely variant fates and gene expression patterns, thus challenging the view that chromatin domains determine function in the genome.
Tom Misteli, Elizabeth H. Finn
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RNA in chromatin organization and nuclear architecture
Current Opinion in Genetics & DevelopmentIn the cell nucleus, genomic DNA is surrounded by nonmembranous nuclear bodies. This might result from specific regions of the genome being transcribed into long noncoding RNAs (lncRNAs), which tend to remain at the sites of their own transcription. The lncRNAs seed the nuclear bodies by recruiting and concentrating proteins and RNAs, which undergo ...
Maierdan Palihati, Noriko Saitoh
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Chromatin Architectures and Hox Gene Collinearity
2013Ever since the observation that collinearity, that is, the sequential activity of Hox genes based on their relative positions within their gene clusters, is conserved throughout most of the animal kingdom, the question has been raised as to what are the underlying molecular mechanisms.
Noordermeer, D. and Duboule, D.
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The logic of chromatin architecture and remodelling at promoters
Nature, 2009The regulation of gene transcription involves a dynamic balance between packaging regulatory sequences into chromatin and allowing transcriptional regulators access to these sequences. Access is restricted by the nucleosomes, but these can be repositioned or ejected by enzymes known as nucleosome remodellers.
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