Results 211 to 220 of about 2,183,040 (299)

Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture. [PDF]

Sci Adv
Fukai YT, Kujirai T, Wakamori M, Kanamura S, Yamauchi L, Zeraati S, Morita S, Tanegashima C, Kadota M, Shirouzu M, Kurumizaka H, Umehara T, Kawaguchi K.   +12 more
europepmc   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Interplay Between 3D Chromatin Architecture and Gene Regulation at the <i>APOE</i> Locus Contributes to Alzheimer's Disease Risk. [PDF]

Int J Mol Sci
Lee EG, Leong L, Chen S, Tulloch J, Yu CE.   +4 more
europepmc   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Adversarial attack of sequence-free enhancer prediction identifies chromatin architecture. [PDF]

Bioinformatics
Gafur J, Lang OW, Lai WKM.
europepmc   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Self-organization of Drosophila chromatin architecture in a cell-free system

Jayakrishnan M, Kars G, Campos-Sparr A, Karpinska MA, Zunjarrao S, Maziak N, Margulies CE, Vaquerizas JM, Gambetta MC, Oudelaar AM, Becker PB.   +10 more
europepmc   +1 more source

Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes. [PDF]

Nat Commun
Haydar S, Bednarz R, Laurette P, Sobitov I, Díaz I Pedrosa N, Videm P, Lueneburg T, Kuß S, Lahm H, Dreßen M, Krane M, Schmidt C, Grüning BA, Voigt N, Streckfuss-Bömeke K, Gilsbach R.   +15 more
europepmc   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Metal ion homeostasis regulates condensin-dependent chromatin architecture and chromosome segregation in Schizosaccharomyces pombe. [PDF]

J Microbiol
An SH, Kim KD.
europepmc   +1 more source