Results 261 to 270 of about 2,183,040 (299)

The architecture and function of the chromatin replication machinery

Current Opinion in Structural Biology, 2017
Genomic DNA in eukaryotic cells is packaged into nucleosome arrays. During replication, nucleosomes need to be dismantled ahead of the advancing replication fork and reassembled on duplicated DNA. The architecture and function of the core replisome machinery is now beginning to be elucidated, with recent insights shaping our view on DNA replication ...
Thomas Cr, Miller, Alessandro, Costa
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Chromatin Architectures and Hox Gene Collinearity

2013
Ever since the observation that collinearity, that is, the sequential activity of Hox genes based on their relative positions within their gene clusters, is conserved throughout most of the animal kingdom, the question has been raised as to what are the underlying molecular mechanisms.
Noordermeer, D. and Duboule, D.
openaire   +5 more sources

Interplay and Dynamics of Chromatin Architecture and DNA Damage Response: An Overview [PDF]

Cancers
Susanna Ambrosio, Stefano Amente, Barbara Majello   +2 more
exaly   +2 more sources

Chromatin architecture is a flexible foundation for gene expression

Nature Genetics, 2021
The structure of chromatin is associated with its function, but precisely how is unclear. New data show that the higher-order architecture of the genome is similar among cell types with widely variant fates and gene expression patterns, thus challenging the view that chromatin domains determine function in the genome.
Tom Misteli, Elizabeth H. Finn
openaire   +2 more sources

The logic of chromatin architecture and remodelling at promoters

Nature, 2009
The regulation of gene transcription involves a dynamic balance between packaging regulatory sequences into chromatin and allowing transcriptional regulators access to these sequences. Access is restricted by the nucleosomes, but these can be repositioned or ejected by enzymes known as nucleosome remodellers.
openaire   +2 more sources

RNA in chromatin organization and nuclear architecture

Current Opinion in Genetics & Development
In the cell nucleus, genomic DNA is surrounded by nonmembranous nuclear bodies. This might result from specific regions of the genome being transcribed into long noncoding RNAs (lncRNAs), which tend to remain at the sites of their own transcription. The lncRNAs seed the nuclear bodies by recruiting and concentrating proteins and RNAs, which undergo ...
Maierdan Palihati, Noriko Saitoh
openaire   +2 more sources

Primary architecture of chromatin fibers

Science, 2020
Chromatin Sequencing The organization of chromosomal DNA, including the positioning of nucleosomes and nucleosome-free regions harboring regulatory proteins along single chromatin fibers, is fundamental to genome function. However, most sequencing methods cannot elucidate this organization at the nucleotide level. Stergachis et al. present an approach,
openaire   +1 more source

Characterizing the molecular architectures of chromatin-modifying complexes

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017
Eukaryotic cells package their genome in the form of a DNA-protein complex known as chromatin. This organization not only condenses the genome to fit within the confines of the nucleus, but also provides a platform for a cell to regulate accessibility to different gene sequences.
Dheva T. Setiaputra, Calvin K. Yip
openaire   +2 more sources

BIOMOLECULAR CONDENSATES IN REGULATION OF TRANSCRIPTION AND CHROMATIN ARCHITECTURE

Биохимия / Biochemistry
Recent research highlights the pivotal role of liquid-like complexes – biomolecular condensates – in gene control. Biomolecular condensates involve enhancers and gene promoters into microenvironments with specific composition, capable of both activating and repressing transcription or maintaining its appropriate level.
Arseniy V, Selivanovskiy, Sergey V, Razin, Sergei V, Ulianov   +2 more
openaire   +2 more sources

Nascent RNA synthesis in the context of chromatin architecture

Chromosome Research, 2004
Based on the idea that chromatin domains provide physical barriers for large molecules and multi-enzyme complexes, including the components of the transcription machinery, it has been proposed that transcription should be confined to the surfaces of chromatin domains.
Nicolas, Sadoni, Daniele, Zink
openaire   +2 more sources