Results 81 to 90 of about 83,148 (303)

Thermodynamic pathways to genome spatial organization in the cell nucleus [PDF]

, 2009
The architecture of the eukaryotic genome is characterized by a high degree of spatial organization. Chromosomes occupy preferred territories correlated to their state of activity and, yet, displace their genes to interact with remote sites in complex ...
A. Prisco, Prisco, Antonella, Nicodemi, Mario   +2 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Lnc-ing Trained Immunity to Chromatin Architecture

Frontiers in Cell and Developmental Biology, 2019
Human innate immune cells exposed to certain infections or stimuli develop enhanced immune responses upon re-infection with a different second stimulus, a process termed trained immunity.
Stephanie Fanucchi, Stephanie Fanucchi, Musa M. Mhlanga   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes [PDF]

, 2005
Studies of higher-order chromatin arrangements are an essential part of ongoing attempts to explore changes in epigenome structure and their functional implications during development and cell differentiation.
Kreth Gregor, Michael R Speicher, Bolzer Andreas, Cremer Christoph, Kreth, G., Andreas Bolzer (83), Cremer, Christoph, Eils, R., Christoph Cremer, Christoph Cremer (91), Fauth Christine, Irina Solovei, Solovei, Irina, Daniela Koehler, Gregor Kreth (84), Eils, Roland, Gregor Kreth, Kaan Saracoglu, Bolzer, Andreas, Koehler Daniela, Irina Solovei (85), Fauth, C., Thomas Cremer (93), Bolzer, A., Speicher, Michael R., Müller Stefan, Solovei Irina, Müller, Stefan, Saracoglu, Kaan, Stefan Müller, Fauth, Christine, Roland Eils (90), Kreth, Gregor, Cremer Thomas, Koehler, D., Stefan Müller (89), Michael R Speicher (27551), Thomas Cremer, Solovei, I., Roland Eils, Müller, S., Cremer, C., Koehler, Daniela, Speicher, M.R., Eils Roland, Speicher Michael R, Cremer, Thomas, Andreas Bolzer, Daniela Koehler (86), Christine Fauth (88), Cremer, T., Saracoglu Kaan, Christine Fauth, Kaan Saracoglu (87), Saracoglu, K.   +54 more
core   +1 more source

Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos

Nature Communications, 2020
The organisation of chromatin in somatic cell nuclear transfer (SCNT) embryos remains poorly understood. Here, the authors examine higher order chromatin structures of mouse SCNT embryos and provide insights into chromatin architecture reorganisation ...
Mo Chen, Qianshu Zhu, Chong Li, Xiaochen Kou, Yanhong Zhao, Yanhe Li, Ruimin Xu, Lei Yang, Lingyue Yang, Liang Gu, Hong Wang, Xiaoyu Liu, Cizhong Jiang, Shaorong Gao   +13 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Genome organization of DNA replication timing and its link to chromatin and transcription [PDF]

, 2008
The replication of the genome is a highly organized process. Not every sequence replicates at the same time, instead some genes replicate early, while others replicate later during S phase.
Schwaiger, Michaela
core   +1 more source

The insulator EACBE regulates V(D)J recombination of Tcrd gene by modulating chromatin organization

Frontiers in Immunology
T cell receptor (TCR) diversity, essential for the recognition of a wide array of antigens, is generated through V(D)J recombination. The Tcra and Tcrd genes reside within a shared genomic locus, with Tcrd rearrangement occurring first in the double ...
Yongchang Zhu, Yongchang Zhu, Ranran Dai, Ranran Dai, Hao Zhao, Junwei Luo, Keyi Li, Wei Xue, Litao Qin, Hongyuan Pan, Shixiu Liao, Bingtao Hao, Bingtao Hao   +12 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source