Results 61 to 70 of about 83,148 (303)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling [PDF]

, 2008
In the plant pathogen Phytophthora infestans, nuclear integration of inf1 transgenic DNA sequences results in internuclear gene silencing of inf1. Although silencing is regulated at the transcriptional level, it also affects transcription from other ...
Li, S., Appiah, A.A., Shepherd, S.J., Walker, C.A., Grenville-Briggs, L., Govers, F., van West, P., West, P., van, Gow, N.A.R.   +8 more
core   +1 more source

Dynamic chromatin architecture of the porcine adipose tissues with weight gain and loss

Nature Communications, 2023
Using an adult female miniature pig model with diet-induced weight gain/weight loss, we investigated the regulatory mechanisms of three-dimensional (3D) genome architecture in adipose tissues (ATs) associated with obesity.
Long Jin, Danyang Wang, Jiaman Zhang, Pengliang Liu, Yujie Wang, Yu Lin, Can Liu, Ziyin Han, Keren Long, Diyan Li, Yu Jiang, Guisen Li, Yu Zhang, Jingyi Bai, Xiaokai Li, Jing Li, Lu Lu, Fanli Kong, Xun Wang, Hua Li, Zhiqing Huang, Jideng Ma, Xiaolan Fan, Linyuan Shen, Li Zhu, Yanzhi Jiang, Guoqing Tang, Bin Feng, Bo Zeng, Liangpeng Ge, Xuewei Li, Qianzi Tang, Zhihua Zhang, Mingzhou Li   +33 more
doaj   +1 more source

Chromosome conformation capture technologies as tools to detect structural variations and their repercussion in chromatin 3D configuration

Frontiers in Cell and Developmental Biology, 2023
3D genome organization regulates gene expression in different physiological and pathological contexts. Characterization of chromatin structure at different scales has provided information about how the genome organizes in the nuclear space, from ...
Aura Stephenson-Gussinye, Mayra Furlan-Magaril   +1 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Live-cell visualisation of chromatin for the study of radiation-induced chromosome aberrations [PDF]

, 2011
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.Chromosomes can be visualised during the metaphase stage of the cell cycle however, there are various limitations associated with the visualisation of ...
Malis, Georgios
core  

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains [PDF]

, 2011
The ATP-dependent chromatin-remodelling enzyme Chd1 is a 168-kDa protein consisting of a double chromodomain, Snf2-related ATPase domain, and a C-terminal DNA-binding domain.
Daniel P Ryan, Singh, Vijender, Owen-Hughes, Tom; id_orcid, Martin, David; id_orcid, David Martin, Ramasubramanian Sundaramoorthy, Vijender Singh, Sundaramoorthy, Ramasubramanian, Ryan, Daniel P., Tom Owen-Hughes   +9 more
core   +1 more source

BRD4 Phosphorylation Regulates the Structure of Chromatin Nanodomains

Cells
The interplay between chromatin structure and phase-separating proteins is an emerging topic in cell biology with implications for understanding disease states.
Clayton Seitz, Donghong Fu, Mengyuan Liu, Hailan Ma, Jing Liu   +4 more
doaj   +1 more source

Extensive Chromatin Structure-Function Associations Revealed by Accurate 3D Compartmentalization Characterization

Frontiers in Cell and Developmental Biology, 2022
A/B compartments are observed in Hi-C data and coincide with eu/hetero-chromatin. However, many genomic regions are ambiguous under A/B compartment scheme.
Zi Wen, Zi Wen, Weihan Zhang, Quan Zhong, Quan Zhong, Jinsheng Xu, Jinsheng Xu, Chunhui Hou, Zhaohui Steve Qin, Li Li, Li Li, Li Li   +11 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source