Results 41 to 50 of about 2,271,159 (299)

Recruitment of Oct4 protein to UV-damaged chromatin in embryonic stem cells. [PDF]

, 2011
BACKGROUND: Oct4 is a specific marker of embryonic stem cell (ESC) pluripotency. However, little is known regarding how Oct4 responds to DNA damage. Here, we investigated whether Oct4 recognizes damaged chromatin in mouse ESCs stably expressing GFP-Oct4.
Kozubek, Stanislav, Foltankova, Veronika, Stanislav Kozubek, Gabriela Šustáčková, Lenka Stixová, Stixová Lenka, Soňa Legartová, Bartova, Eva, Veronika Foltánková, Kozubek Stanislav, Bártová Eva, Legartová Soňa, Foltánková Veronika, Stixova, Lenka, Legartova, Sona, Eva Bártová, Sustackova, Gabriela, Šustáčková Gabriela   +17 more
core   +2 more sources

Nuclear architecture explored by live-cell fluorescence microscopy using laser and ion microbeam irradiation. [PDF]

, 2010
Nuclear architecture is a biological field of research that studies the spatio-temporal organization of the components within cell nuclei. Since nuclei are the organelles that harbor the genome and epigenome, they are the place where most of the genetic ...
Strickfaden, Hilmar
core   +1 more source

Role of Non-Coding RNAs in Acute Myeloid Leukemia

Non-Coding RNA
Acute myeloid leukemia (AML) is a highly heterogeneous disease, with significantly higher incidence and fatality rates in the elderly. Even with recent decades of research progress in AML, the exact etiology of this deadly disease is still not fully ...
Shailendra S. Maurya, Sarita Maurya, Sumit K. Chaturvedi   +2 more
doaj   +1 more source

Initial Genomics of the Human Nucleolus [PDF]

, 2010
We report for the first time the genomics of a nuclear compartment of the eukaryotic cell. 454 sequencing and microarray analysis revealed the pattern of nucleolus-associated chromatin domains (NADs) in the linear human genome and identified different ...
Laengst, Gernot, Santoyo-Lopez, Javier, Bálint Péterfia, Montaner David, Längst, Gernot, Conesa, Ana, Javier Santoyo-Lopez, Irina Solovei, Solovei, Irina, Dopazo, Joaquin, Cremer Thomas, Thomas Cremer, Joaquin Dopazo, Ignacio Medina, Nemeth, Attila, Medina, Ignacio, Längst Gernot, Akhtar, Asifa, Medina Ignacio, Németh Attila, Peterfia, Balint, Gernot Längst, Cremer, Thomas, Péterfia Bálint, Montaner, David, Solovei Irina, Attila Németh, Ana Conesa, Santoyo-Lopez Javier, Dopazo Joaquin, Conesa Ana, David Montaner   +31 more
core   +2 more sources

An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis

Nature Communications, 2019
CTCF plays key roles in gene regulation, chromatin insulation and organizing the higher-order chromatin architecture of mammalian genomes. Here the authors investigate the function an alternatively spliced shorter CTCF isoform, finding that this isoform ...
Jiao Li, Kaimeng Huang, Gongcheng Hu, Isaac A. Babarinde, Yaoyi Li, Xiaotao Dong, Yu-Sheng Chen, Liping Shang, Wenjing Guo, Junwei Wang, Zhaoming Chen, Andrew P. Hutchins, Yun-Gui Yang, Hongjie Yao   +13 more
doaj   +1 more source

Identification and validation of transcription factors that regulate chromatin dynamics [PDF]

, 2012
Gene expression has to be tightly regulated during all cellular processes. During embryonic development differentiating cells loose their developmental potential and acquire specific functions by activating lineage-specific genes.
Schöler, Anne
core   +1 more source

Chromatin and Nuclear Architecture in Stem Cells [PDF]

, 2020
Here we outline the contents of Stem Cell Reports' first special issue, on chromatin and nuclear architecture in stem cells. It features both reviews and original research articles, covering emerging topics in nuclear architecture including 3D genome ...
Plath, Kathrin, Meshorer, Eran, Kathrin Plath, Eran Meshorer   +3 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Chromosome conformation capture technologies as tools to detect structural variations and their repercussion in chromatin 3D configuration

Frontiers in Cell and Developmental Biology, 2023
3D genome organization regulates gene expression in different physiological and pathological contexts. Characterization of chromatin structure at different scales has provided information about how the genome organizes in the nuclear space, from ...
Aura Stephenson-Gussinye, Mayra Furlan-Magaril   +1 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source