Results 21 to 30 of about 77,159 (253)
Genome Biology, 2017 Background The structure and mechanical properties of chromatin impact DNA functions and nuclear architecture but remain poorly understood. In budding yeast, a simple polymer model with minimal sequence-specific constraints and a small number of ...
Jean-Michel Arbona +3 more
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Chromatin information content landscapes inform transcription factor and DNA interactions
Nature Communications, 2021 Interaction between transcription factors and chromatin is fundamental for genome organization and regulation. Here, the authors use information theory to measure signatures of organized chromatin resulting from transcription factor-chromatin ...
Ricardo D’Oliveira Albanus +6 more
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Genetic Architecture of Transcription and Chromatin Regulation [PDF]
Genomics & Informatics, 2015 DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures. In particular, chromatin opening is tightly coupled with gene transcription.
Kwoneel Kim +3 more
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Effects of DNA supercoiling on chromatin architecture [PDF]
Biophysical Reviews, 2016 Disruptions in chromatin structure are necessary for the regulation of eukaryotic genomes, from remodelling of nucleosomes at the base pair level through to large-scale chromatin domains that are hundreds of kilobases in size. RNA polymerase is a powerful motor which, prevented from turning with the tight helical pitch of the DNA, generates over-wound ...
Samuel Corless, Nick Gilbert
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Single Cell Imaging of Nuclear Architecture Changes
Frontiers in Cell and Developmental Biology, 2019 The dynamic architecture of chromatin, the macromolecular complex comprised primarily of DNA and histones, is vital for eukaryotic cell growth. Chemical and conformational changes to chromatin are important markers of functional and developmental ...
Rikke Brandstrup Morrish +7 more
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Molecular Systems Biology, 2015 Mammalian chromosomes fold into arrays of megabase‐sized topologically associating domains (TADs), which are arranged into compartments spanning multiple megabases of genomic DNA.
James Fraser +22 more
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Role of Non-Coding RNAs in Acute Myeloid Leukemia
Non-Coding RNAAcute myeloid leukemia (AML) is a highly heterogeneous disease, with significantly higher incidence and fatality rates in the elderly. Even with recent decades of research progress in AML, the exact etiology of this deadly disease is still not fully ...
Shailendra S. Maurya +2 more
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Nature Communications, 2019 CTCF plays key roles in gene regulation, chromatin insulation and organizing the higher-order chromatin architecture of mammalian genomes. Here the authors investigate the function an alternatively spliced shorter CTCF isoform, finding that this isoform ...
Jiao Li +13 more
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Architecture of SWI/SNF chromatin remodeling complex
Protein & Cell, 2018 Zhihui Zhang +8 more
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PLoS Pathogens, 2020 DNA viruses can hijack and manipulate the host chromatin state to facilitate their infection. Multiple lines of evidences reveal that DNA virus infection results in the host chromatin relocation, yet there is little known about the effects of viral ...
Xiangshuo Kong +8 more
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