Results 11 to 20 of about 77,159 (253)
An Isochore Framework Underlies Chromatin Architecture. [PDF]
PLoS ONE, 2017 A recent investigation showed the existence of correlations between the architectural features of mammalian interphase chromosomes and the compositional properties of isochores.
Kamel Jabbari, Giorgio Bernardi
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Manipulating chromatin architecture in C. elegans
Epigenetics & Chromatin, 2022 Background Nucleosome-mediated chromatin compaction has a direct effect on the accessibility of trans-acting activators and repressors to DNA targets and serves as a primary regulatory agent of genetic expression. Understanding the nature and dynamics of
John L. Carter +3 more
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The quantitative architecture of centromeric chromatin [PDF]
eLife, 2014 The centromere, responsible for chromosome segregation during mitosis, is epigenetically defined by CENP-A containing chromatin. The amount of centromeric CENP-A has direct implications for both the architecture and epigenetic inheritance of centromeres.
Dani L Bodor +9 more
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Editorial: Probing the Chromatin Architecture [PDF]
Frontiers in Cell and Developmental Biology, 2021 Francesca Palombo +4 more
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Architectural RNA in chromatin organization [PDF]
Biochemical Society Transactions, 2020 RNA plays a well-established architectural role in the formation of membraneless interchromatin nuclear bodies. However, a less well-known role of RNA is in organizing chromatin, whereby specific RNAs have been found to recruit chromatin modifier proteins.
Jitendra Thakur, Steven Henikoff
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The Dynamic Chromatin Architecture of the Regenerating Liver [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2019 ABSTRACT Background & Aims The adult liver is the main detoxification organ and is routinely exposed to environmental insults but retains the ability to restore its mass and function upon tissue damage.
Wang, Amber W. +5 more
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Chromatin Architecture Reconstruction [PDF]
Biophysical Journal, 2012 Three-dimensional genomic architecture is increasingly being found to play an important role in the regulation of gene expression through direct physical interactions of distant genomic sites. Conformation Capture Techniques (CCTs) attempt to resolve the conformation of a genetic sequence or entire genome by measuring mean interaction frequencies ...
Diesinger, Philipp M. +4 more
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Chromatin architecture underpinning transcription elongation [PDF]
Nucleus, 2016 RNA polymerase 2 (pol2) associates with enhancers and promoters, followed by transcription initiation and subsequent pausing. Upon release, pol2 proceeds into productive elongation. A wide spread view of transcription holds that during elongation, pol2 and associated factors clear the promoter proximal region to track along the chromatin fiber until a ...
Kiwon, Lee, Gerd A, Blobel
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Molecular Systems Biology, 2017 Polycomb repression in mouse embryonic stem cells (ESCs) is tightly associated with promoter co‐occupancy of RNA polymerase II (RNAPII) which is thought to prime genes for activation during early development. However, it is unknown whether RNAPII poising
Carmelo Ferrai +11 more
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Chromatin architecture defines the glucocorticoid response [PDF]
Molecular and Cellular Endocrinology, 2013 The glucocorticoid receptor (GR) functions to regulate a wide group of physiological processes through hormone inducible interaction with genomic loci and subsequent manipulation of the transcriptional output of target genes. Despite expression in a wide variety of tissues, the GR has diverse roles that are regulated tightly in a cell type specific ...
Craig J, Burd, Trevor K, Archer
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