Results 1 to 10 of about 2,183,040 (299)

Probing Chromatin Compaction and Its Epigenetic States in situ With Single-Molecule Localization-Based Super-Resolution Microscopy

Frontiers in Cell and Developmental Biology, 2021
Chromatin organization play a vital role in gene regulation and genome maintenance in normal biological processes and in response to environmental insults.
Jianquan Xu, Yang Liu, Yang Liu
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Cohesin Mutations Induce Chromatin Conformation Perturbation of the H19/IGF2 Imprinted Region and Gene Expression Dysregulation in Cornelia de Lange Syndrome Cell Lines

Biomolecules, 2021
Traditionally, Cornelia de Lange Syndrome (CdLS) is considered a cohesinopathy caused by constitutive mutations in cohesin complex genes. Cohesin is a major regulator of chromatin architecture, including the formation of chromatin loops at the imprinted ...
Silvana Pileggi, Marta La Vecchia, Elisa Adele Colombo, Laura Fontana, Patrizia Colapietro, Davide Rovina, Annamaria Morotti, Silvia Tabano, Giovanni Porta, Myriam Alcalay, Cristina Gervasini, Monica Miozzo, Silvia Maria Sirchia   +12 more
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Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver

Cell Discovery, 2022
Liver development is a complex process that is regulated by a series of signaling pathways. Three-dimensional (3D) chromatin architecture plays an important role in transcriptional regulation; nonetheless, its dynamics and role in the rapid transition of
Luxi Chen, Jing Li, Renqiang Yuan, Yujie Wang, Jiaman Zhang, Yu Lin, Lina Wang, Xingxing Zhu, Wei Zhu, Jingyi Bai, Fanli Kong, Bo Zeng, Lu Lu, Jideng Ma, Keren Long, Long Jin, Zhiqing Huang, Jinlong Huo, Yiren Gu, Danyang Wang, Delin Mo, Diyan Li, Qianzi Tang, Xuewei Li, Jiangwei Wu, Yaosheng Chen, Mingzhou Li   +26 more
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Multi-level remodelling of chromatin underlying activation of human T cells

Scientific Reports, 2021
Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage development but less so in response to cell perturbation.
Naiara G. Bediaga, Hannah D. Coughlan, Timothy M. Johanson, Alexandra L. Garnham, Gaetano Naselli, Jan Schröder, Liam G. Fearnley, Esther Bandala-Sanchez, Rhys S. Allan, Gordon K. Smyth, Leonard C. Harrison   +10 more
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Cryo-ET study from in vitro to in vivo revealed a general folding mode of chromatin with two-start helical architecture

Cell Reports, 2023
Summary: The organization and dynamics of chromatin fiber play crucial roles in regulating DNA accessibility for gene expression. Here we combine cryoelectron tomography (cryo-ET), sub-volume averaging, and 3D segmentation to visualize the in vitro and ...
Yan Li, Haonan Zhang, Xiaomin Li, Wanyu Wu, Ping Zhu   +4 more
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Targeting Epigenetic Mechanisms in Vascular Aging

Frontiers in Cardiovascular Medicine, 2022
Environment, diseases, lack of exercise, and aged tendency of population have becoming crucial factors that induce vascular aging. Vascular aging is unmodifiable risk factor for diseases like diabetes, hypertension, atherosclerosis, and hyperlipidemia ...
Zhongxiao Lin, Zhongxiao Lin, Qian Ding, Xinzhi Li, Yuliang Feng, Hao He, Chuoji Huang, YiZhun Zhu, YiZhun Zhu   +8 more
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Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells

eLife, 2015
Dynamic post-translational modification of RNA polymerase II (RNAPII) coordinates the co-transcriptional recruitment of enzymatic complexes that regulate chromatin states and processing of nascent RNA.
João D Dias, Tiago Rito, Elena Torlai Triglia, Alexander Kukalev, Carmelo Ferrai, Mita Chotalia, Emily Brookes, Hiroshi Kimura, Ana Pombo   +8 more
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Predicting Genome Architecture: Challenges and Solutions

Frontiers in Genetics, 2021
Genome architecture plays a pivotal role in gene regulation. The use of high-throughput methods for chromatin profiling and 3-D interaction mapping provide rich experimental data sets describing genome organization and dynamics.
Polina Belokopytova, Polina Belokopytova, Veniamin Fishman, Veniamin Fishman   +3 more
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RNA polymerase II primes Polycomb‐repressed developmental genes throughout terminal neuronal differentiation

Molecular Systems Biology, 2017
Polycomb repression in mouse embryonic stem cells (ESCs) is tightly associated with promoter co‐occupancy of RNA polymerase II (RNAPII) which is thought to prime genes for activation during early development. However, it is unknown whether RNAPII poising
Carmelo Ferrai, Elena Torlai Triglia, Jessica R Risner‐Janiczek, Tiago Rito, Owen JL Rackham, Inês de Santiago, Alexander Kukalev, Mario Nicodemi, Altuna Akalin, Meng Li, Mark A Ungless, Ana Pombo   +11 more
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Inferring the physical properties of yeast chromatin through Bayesian analysis of whole nucleus simulations

Genome Biology, 2017
Background The structure and mechanical properties of chromatin impact DNA functions and nuclear architecture but remain poorly understood. In budding yeast, a simple polymer model with minimal sequence-specific constraints and a small number of ...
Jean-Michel Arbona, Sébastien Herbert, Emmanuelle Fabre, Christophe Zimmer   +3 more
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