Results 31 to 40 of about 2,271,159 (299)
Regulation of Chromatin Architecture by Transcription Factor Binding
eLife, 2023 Abstract Transcription factors (TF) bind to chromatin and regulate the expression of genes. The pair Myc:Max binds to E-box regulatory DNA elements throughout the genome, controlling transcription of a large group of specific genes. We introduce an implicit modeling protocol for Myc:Max binding to mesoscale chromatin fibers to determine
Stephanie Portillo-Ledesma +3 more
openaire +4 more sources
Perturbation of chromatin structure globally affects localization and recruitment of splicing factors [PDF]
, 2012 Chromatin structure is an important factor in the functional coupling between transcription and mRNA processing, not only by regulating alternative splicing events, but also by contributing to exon recognition during constitutive splicing.
Risso, Guillermo, J +47 more
core +1 more source
Genome Biology, 2017 Background The structure and mechanical properties of chromatin impact DNA functions and nuclear architecture but remain poorly understood. In budding yeast, a simple polymer model with minimal sequence-specific constraints and a small number of ...
Jean-Michel Arbona +3 more
doaj +1 more source
Chromatin information content landscapes inform transcription factor and DNA interactions
Nature Communications, 2021 Interaction between transcription factors and chromatin is fundamental for genome organization and regulation. Here, the authors use information theory to measure signatures of organized chromatin resulting from transcription factor-chromatin ...
Ricardo D’Oliveira Albanus +6 more
doaj +1 more source
Chromatin architecture underpinning transcription elongation [PDF]
Nucleus, 2016 RNA polymerase 2 (pol2) associates with enhancers and promoters, followed by transcription initiation and subsequent pausing. Upon release, pol2 proceeds into productive elongation. A wide spread view of transcription holds that during elongation, pol2 and associated factors clear the promoter proximal region to track along the chromatin fiber until a ...
Kiwon, Lee, Gerd A, Blobel
openaire +2 more sources
Molecular Systems Biology, 2015 Mammalian chromosomes fold into arrays of megabase‐sized topologically associating domains (TADs), which are arranged into compartments spanning multiple megabases of genomic DNA.
James Fraser +22 more
doaj +1 more source
3D Analysis of chromosome architecture: advantages and limitations with SEM [PDF]
, 2005 Three-dimensional mitotic plant chromosome architecture can be investigated with the highest resolution with scanning electron microscopy compared to other microscopic techniques at present.
Formanek, H. +2 more
core +1 more source
A SWI/SNF Chromatin Remodelling Protein Controls Cytokinin Production through the Regulation of Chromatin Architecture [PDF]
, 2015 Chromatin architecture determines transcriptional accessibility to DNA and consequently gene expression levels in response to developmental and environmental stimuli.
Hirt, Heribert +43 more
core +2 more sources
Single Cell Imaging of Nuclear Architecture Changes
Frontiers in Cell and Developmental Biology, 2019 The dynamic architecture of chromatin, the macromolecular complex comprised primarily of DNA and histones, is vital for eukaryotic cell growth. Chemical and conformational changes to chromatin are important markers of functional and developmental ...
Rikke Brandstrup Morrish +7 more
doaj +1 more source
Ultrastructural analysis of chromatin in meiosis I plus II of rye (Secale cereale L.) [PDF]
, 2004 Scanning electron microscopy (SEM) proves to be an appropriate technique for imaging chromatin organization in meiosis I and II of rye (Secale cereale) down to a resolution of a few nanometers.
Herrmann, Reinhold G. +3 more
core +1 more source