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The role of nucleoplasmin in chromatin assembly and disassembly
Nucleoplasmin is the most abundant nuclear protein in Xenopus oocytes and eggs. The term ‘molecular chaperone’ was coined to describe its role in the assembly of the nucleosome subunits of chromatin. Although histones and DNA can self-assemble into nucleosomes, nucleoplasmin can facilitate this process ...
Ronald A. Laskey +5 more
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Initiation of genome replication: assembly and disassembly of replication-competent chromatin
Considerable progress has been made in research on the initiation of eukaryotic genome replication. This has generated a number of recent review articles. Here, we briefly summarize the major conclusions described in these articles and also include the results of more recent primary articles.
Marion Ritzi, Rolf Knippers
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Histone Chaperones in the Assembly and Disassembly of Chromatin
As we learned in the previous chapter, the eukaryotic genome exists in our cells as the nucleoprotein complex chromatin. A human cell contains approximately 40 million nucleosomes, which are the fundamental repeating units of chromatin. As expected for a highly conserved structure, such as that of the nucleosome, its assembly is tightly orchestrated ...
Briana K. Dennehey, Jessica K. Tyler
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Systemwide disassembly and assembly of SCF ubiquitin ligase complexes
Cell, 2023Kheewoong Baek +2 more
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H2A mono-ubiquitination differentiates FACT’s functions in nucleosome assembly and disassembly
Nucleic Acids Research, 2022zhaojicheng, Shuo-Xing Dou, Peng-Ye Wang
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Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability
Nature Cell Biology, 2023Simone Sidoli +2 more
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