Results 71 to 80 of about 357,335 (290)

The BAH domain of Rsc2 is a histone H3 binding domain [PDF]

, 2013
Bromo-adjacent homology (BAH) domains are commonly found in chromatin-associated proteins and fall into two classes; Remodels the Structure of Chromatin (RSC)-like or Sir3-like. Although Sir3-like BAH domains bind nucleosomes, the binding partners of RSC-
Adams, Angus-Hill, Anna L. Chambers, Antony W. Oliver, Armache, Badis, Bamford, Bochar, Burrows, Cairns, Cairns, Callebaut, CCP4, Chambers, Chen, Corpet, Davis, DeMase, Desai, Downs, Duncker, Emsley, Ericsson, Faucher, Foster, Gartenberg, Gartenberg, Goodwin, Hickman, Hsu, Huang, Jessica A. Downs, Jones, Kabsch, Kasten, Kent, Kuo, Lacoste, Langst, Laurence H. Pearl, Lee, Leslie, Livingstone, Longtine, McCoy, Mohrmann, Muller, Ng, Noguchi, Norris, Norris, Oliver, Onishi, Park, Peng, Ralhan, Shim, Strahl-Bolsinger, Tanny, Varela, Weissman, Xia   +61 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage

Genome Biology, 2020
Background Structural maintenance of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell cycle. The SMC family member condensin is best known for establishing long-range chromatin interactions in mitosis ...
Yasutaka Kakui, Christopher Barrington, David J. Barry, Tereza Gerguri, Xiao Fu, Paul A. Bates, Bhavin S. Khatri, Frank Uhlmann   +7 more
doaj   +1 more source

Physical constraints in polymer modeling of chromatin associations with the nuclear periphery at kilobase scale

Nucleus, 2021
Interactions of chromatin with the nuclear lamina imposes a radial genome distribution important for nuclear functions. How physical properties of chromatin affect these interactions is unclear.
Annaël Brunet, Nicolas Destainville, Philippe Collas   +2 more
doaj   +1 more source

The regulation of Hox gene expression during animal development [PDF]

, 2013
Hox genes encode a family of transcriptional regulators that elicit distinct developmental programmes along the head-to-tail axis of animals. The specific regional functions of individual Hox genes largely reflect their restricted expression patterns ...
Alonso, Claudio R, Mallo, Moisés
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Statistical mechanics of nucleosome ordering by chromatin structure-induced two-body interactions

, 2011
One-dimensional arrays of nucleosomes (DNA-bound histone octamers separated by stretches of linker DNA) fold into higher-order chromatin structures which ultimately make up eukaryotic chromosomes.
Chereji, Răzvan V., Locke, George, Morozov, Alexandre V., Tolkunov, Denis   +3 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

ProbC: joint modeling of epigenome and transcriptome effects in 3D genome

BMC Genomics, 2022
Background Hi-C and its high nucleosome resolution variant Micro-C provide a window into the spatial packing of a genome in 3D within the cell. Even though both techniques do not directly depend on the binding of specific antibodies, previous work has ...
Emre Sefer
doaj   +1 more source

Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells

eLife, 2021
A longstanding hypothesis is that chromatin fiber folding mediated by interactions between nearby nucleosomes represses transcription. However, it has been difficult to determine the relationship between local chromatin fiber compaction and transcription
Sarah G Swygert, Dejun Lin, Stephanie Portillo-Ledesma, Po-Yen Lin, Dakota R Hunt, Cheng-Fu Kao, Tamar Schlick, William S Noble, Toshio Tsukiyama   +8 more
doaj   +1 more source