Results 51 to 60 of about 357,335 (290)
Frontiers in Genetics, 2021 Single-cell open-chromatin profiles have the potential to reveal the pattern of chromatin-interaction in a cell type. However, currently available cis-regulatory network prediction methods using single-cell open-chromatin profiles focus more on local ...
Neetesh Pandey +3 more
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Interaction of the Glucocorticoid Receptor with the Chromatin Landscape [PDF]
Molecular Cell, 2008 The generality and spectrum of chromatin-remodeling requirements for nuclear receptor function are unknown. We have characterized glucocorticoid receptor (GR) binding events and chromatin structural transitions across GR-induced or -repressed genes. This analysis reveals that GR binding invariably occurs at nuclease-accessible sites (DHS). A remarkable
John, S +10 more
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Genome-wide association study of chlamydia reinfection in African American women
Frontiers in ImmunologyBackgroundChlamydia trachomatis (Ct) is a bacterium that causes chlamydia, the most diagnosed bacterial sexually transmitted infection (STI) in the world.
Hemant K. Tiwari +7 more
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Nuclear position modulates long-range chromatin interactions.
PLoS Genetics, 2022 The human genome is non-randomly organized within the cell nucleus. Spatial mapping of genome folding by biochemical methods and imaging has revealed extensive variation in locus interaction frequencies between cells in a population and between homologs ...
Elizabeth H Finn, Tom Misteli
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cis-regulatory circuits regulating NEK6 kinase overexpression in transformed B cells Are super-enhancer independent [PDF]
, 2017 Alterations in distal regulatory elements that control gene expression underlie many diseases, including cancer. Epigenomic analyses of normal and diseased cells have produced correlative predictions for connections between dysregulated enhancers and ...
Huang, Yue +6 more
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Most chromatin interactions are not in linkage disequilibrium [PDF]
Genome Research, 2019 Chromatin interactions and linkage disequilibrium (LD) are both pairwise measurements between genomic loci that show block patterns along mammalian chromosomes. Their values are generally high for sites that are nearby in the linear genome but abruptly drop across block boundaries.
Whalen, Sean, Pollard, Katherine S
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Functional interactions between nucleoporins and chromatin [PDF]
Current Opinion in Cell Biology, 2011 As the gatekeepers of the eukaryotic cell nucleus, nuclear pore complexes (NPCs) mediate all molecular trafficking between the nucleoplasm and the cytoplasm. In recent years, transport-independent functions of NPC components, nucleoporins, have been identified including roles in chromatin organization and gene regulation. Here, we summarize our current
Yun, Liang, Martin W, Hetzer
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3D‐Epigenomic Regulation of Gene Transcription in Hepatocellular Carcinoma
Advanced Genetics, 2022 The fundamental cause of transcription dysregulation in hepatocellular carcinoma (HCC) remains elusive. To investigate the underlying mechanisms, comprehensive 3D‐epigenomic analyses are performed in cellular models of THLE2 (a normal hepatocytes cell ...
Yuliang Feng +13 more
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BMC Genomics, 2009 Background ATP-dependent chromatin remodeling and the covalent modification of histones play central roles in determining chromatin structure and function.
Wang Jiang +6 more
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4DGenome: a comprehensive database of chromatin interactions [PDF]
Bioinformatics, 2015 Abstract Motivation: The 3D structure of the genome plays a critical role in regulating gene expression. Recent progress in mapping technologies for chromatin interactions has led to a rapid increase in this kind of interaction data. This trend will continue as research in this burgeoning field intensifies.
Li Teng +3 more
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