CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the {\beta}-globin locus [PDF]
, 2012 The principles underlying the architectural landscape of chromatin beyond the nucleosome level in living cells remains largely unknown despite its potential to play a role in mammalian gene regulation. We investigated the 3-dimensional folding of a 1 Mbp
Ann Dean +56 more
core +6 more sources
Toward a molecular understanding of yeast silent chromatin : roles for H4K16 acetylation and the Sir3 C-terminus [PDF]
, 2012 Discrete regions of the eukaryotic genome assume a heritable chromatin structure that is refractory to gene expression. In budding yeast, silent chromatin is characterized by the loading of the Silent Information Regulatory (Sir) proteins (Sir2, Sir3 and
Oppikofer, Mariano
core +1 more source
The 3D Genome Browser: A web-based browser for visualizing 3D genome organization and long-range chromatin interactions [PDF]
, 2018 Here, we introduce the 3D Genome Browser, http://3dgenome.org, which allows users to conveniently explore both their own and over 300 publicly available chromatin interaction data of different types.
Choudhary, Mayank N.K. +12 more
core +2 more sources
Nucleosome—nucleosome interaction in chromatin
FEBS Letters, 1979 The available data suggest that transcriptional activity of chromatin is connected with its structural changes [ 1,2]. According to the electron microscope evidence, the elementary 100 A chromatin thread can exist in two main states, i.e., in a compact state, which is characterized by tight packing of nucleosomes and in an extended state when the ...
Pospelov, V.A. +2 more
openaire +2 more sources
Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus
eLife, 2023 Promyelocytic leukemia Nuclear Bodies (PML NBs) are nuclear membrane-less organelles physically associated with chromatin underscoring their crucial role in genome function.
Constance Kleijwegt +9 more
doaj +1 more source
CCSI: a database providing chromatin–chromatin spatial interaction information [PDF]
Database, 2016 Distal regulatory elements have been shown to regulate gene transcription through spatial interactions, and single nucleotide polymorphisms (SNPs) are linked with distal gene expression by spatial proximity, which helps to explain the causal role of disease-associated SNPs in non-coding region.
Xiaowei Xie +6 more
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Frontiers in Cell and Developmental Biology, 2022 Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic ...
Julia Madsen-Østerbye +5 more
doaj +1 more source
Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization. [PDF]
, 2014 Vascular endothelial growth factor A (VEGF-A) is a master regulator of angiogenesis, vascular development and function. In this study we investigated the transcriptional regulation of VEGF-A-responsive genes in primary human aortic endothelial cells ...
Benner, Christopher +9 more
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Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. [PDF]
, 2015 The current knowledge on how transcription factors (TFs), the ultimate targets and executors of cellular signalling pathways, are regulated by protein-protein interactions remains limited.
Anna Malovannaya +10 more
core +2 more sources
Epigenetics of Long-Range Chromatin Interactions [PDF]
Pediatric Research, 2007 DNA segments that are separated from the promoter region of a gene by many thousands of bases may nonetheless regulate the transcriptional activity of that gene. This finding has led to the investigation of mechanisms underlying long-range chromatin interactions.
Jian Qun, Ling, Andrew R, Hoffman
openaire +2 more sources